Cannabis Compound Database: Showing Compound Card for Iron (CDB005174)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (134)transporters (16) Show 274 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 19:16:47 UTC

Updated at

2020-12-07 19:11:42 UTC

CannabisDB ID

CDB005174

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Iron

Description

Iron, also known as fe (II) ion or fe(ii), belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom. Iron is a weakly acidic compound (based on its pKa). Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Iron exists in all living species, ranging from bacteria to humans. In humans, iron is involved in ibuprofen action pathway. Iron is also involved in several metabolic disorders, some of which include adenine phosphoribosyltransferase deficiency (APRT), porphyria variegata (PV), adenylosuccinate lyase deficiency, and AICA-ribosiduria. Outside of the human body, Iron has been detected, but not quantified in, several different foods, such as chinese cinnamons, nutmegs, sorghums, mustard spinachs, and acorns. This could make iron a potential biomarker for the consumption of these foods. Iron is a potentially toxic compound. Depletion of iron stores may result in iron-deficiency anemia. Those who are iron deficient may absorb up to 95% of an iron dose. Iron is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
FE (II) ion	ChEBI
Fe(II)	ChEBI
Fe2+	ChEBI
Fe(2+)	ChEBI
Ferrous ion	ChEBI
Iron ion(2+)	ChEBI
Iron(2+)	Kegg
Armco iron	HMDB
Carbonyl iron	HMDB
FE	HMDB
Ferrovac e	HMDB
Hematite	HMDB
Infed	HMDB
Limonite	HMDB
LOHA	HMDB
Magnetite	HMDB
Malleable iron	HMDB
Metopirone	HMDB
Metyrapone	HMDB
PZH2m	HMDB
PZHO	HMDB
Remko	HMDB
Suy-b 2	HMDB
Taconite	HMDB
Venofer	HMDB
Wrought iron	HMDB
Iron hydroxide (fe(OH)3)	MeSH, HMDB
Iron oxyhydroxide	MeSH, HMDB
Ferric hydroxide	MeSH, HMDB
Iron hydroxide (III)	MeSH, HMDB

Chemical Formula

Average Molecular Weight

55.85

Monoisotopic Molecular Weight

55.9349

IUPAC Name

lambda2-iron(2+) ion

Traditional Name

lambda2-iron(2+) ion

CAS Registry Number

15438-31-0

SMILES

[Fe++]

InChI Identifier

InChI=1S/Fe/q+2

InChI Key

CWYNVVGOOAEACU-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom.

Kingdom

Inorganic compounds

Super Class

Homogeneous metal compounds

Class

Homogeneous transition metal compounds

Sub Class

Not Available

Direct Parent

Homogeneous transition metal compounds

Alternative Parents

Not Available

Substituents

Homogeneous transition metal

Molecular Framework

Not Available

External Descriptors

monoatomic dication (CHEBI:29033 )
divalent metal cation (CHEBI:29033 )
iron cation (CHEBI:29033 )
a cation (FE+2 )

Ontology

Physiological effect

Health effect:

Health condition:

Multiple sclerosis

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Food

Biological:

Plant:

Animal

Biological location:

Organ and components:

Biofluid and excreta:

Cell and elements:

Extracellular

Subcellular:

Mitochondria

Role

Industrial application:

Drug

Biological role:

Trace element

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	1538 °C	Not Available
Boiling Point	2862 °C	Wikipedia
Water Solubility	Not Available	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-0.77	ChemAxon
pKa (Strongest Acidic)	4.58	ChemAxon
Physiological Charge	2	ChemAxon
Hydrogen Acceptor Count	0	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	0 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	0 m³·mol⁻¹	ChemAxon
Polarizability	1.78 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Not Available

MS/MS

Type	Description	Splash Key	View
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0a4i-9000000000-af3e7aec4f5bd9668683	2016-08-01	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0a4i-9000000000-af3e7aec4f5bd9668683	2016-08-01	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0a4i-9000000000-af3e7aec4f5bd9668683	2016-08-01	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0udi-9000000000-3335fec4c3184739b75e	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0udi-9000000000-3335fec4c3184739b75e	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0udi-9000000000-3335fec4c3184739b75e	2016-08-03	View Spectrum

NMR

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
Carnitine Synthesis		Not Available
Catecholamine Biosynthesis
Aromatic L-Aminoacid Decarboxylase Deficiency		Not Available
Tyrosine hydroxylase deficiency		Not Available
Cysteine Metabolism

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
5-aminolevulinate synthase, erythroid-specific, mitochondrial	ALAS2	Xp11.21	P22557	details
85/88 kDa calcium-independent phospholipase A2	PLA2G6	22q13.1	O60733	details
Tartrate-resistant acid phosphatase type 5	ACP5	19p13.2	P13686	details
Ribonucleoside-diphosphate reductase large subunit	RRM1	11p15.5	P23921	details
Ribonucleoside-diphosphate reductase subunit M2	RRM2	2p25-p24	P31350	details
NADH-ubiquinone oxidoreductase chain 1	MT-ND1		P03886	details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	14q32.12	O75438	details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	1q23	O75306	details
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	1q23.3	Q99643	details
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	PAOX	10q26.3	Q6QHF9	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	12q22	Q9UI09	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1		O15239	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	12q13.3	Q9NRX3	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	19q13.42	O95167	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	9q33.2	P51970	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	7p21.3	O00483	details
NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L		P03901	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	19p13.3	Q86Y39	details
Lathosterol oxidase	SC5DL	11q23.3	O75845	details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	5q11.1	O43181	details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	11p11.11	O75489	details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	1p34.2-p33	O43920	details
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	18p11.22	P19404	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	2q37.3	O95299	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	22q13.2	P56556	details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	3q13.33	O95168	details
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	5p15	P31040	details
Heme oxygenase 2	HMOX2	16p13.3	P30519	details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	11q13	O00217	details
NADH-ubiquinone oxidoreductase chain 2	MT-ND2		P03891	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	19p13.2	O95182	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	5q31	O43678	details
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	2q33-q34	P28331	details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	3q26.33	O43674	details
NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	11q14.1	O95298	details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	2q31.3	O43676	details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	19p13.12	P17568	details
Acyl carrier protein, mitochondrial	NDUFAB1	16p12.2	O14561	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	7q32	Q16718	details
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial	ETFDH	4q32-q35	Q16134	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	12p13.3	Q16795	details
NADH-ubiquinone oxidoreductase chain 4	MT-ND4		P03905	details
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	11q23	O14521	details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	19p13.3	O75251	details
Xanthine dehydrogenase/oxidase	XDH	2p23.1	P47989	details
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	11q13	P49821	details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	8q13.3	Q9Y6M9	details
NADH-ubiquinone oxidoreductase chain 6	MT-ND6		P03923	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	19p13.2	Q9P0J0	details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	5p15.33	O75380	details
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	1p36.1-p35	P21912	details
Heme oxygenase 1	HMOX1	22q13.1	P09601	details
Uroporphyrinogen decarboxylase	UROD	1p34	P06132	details
Methylsterol monooxygenase 1	MSMO1	4q32-q34	Q15800	details
Phytanoyl-CoA dioxygenase, peroxisomal	PHYH	10p13	O14832	details
Tyrosine 3-monooxygenase	TH	11p15.5	P07101	details
Thyroid peroxidase	TPO	2p25	P07202	details
Lactoperoxidase	LPO	17q23.1	P22079	details
Phenylalanine-4-hydroxylase	PAH	12q22-q24.2	P00439	details
Myeloperoxidase	MPO	17q23.1	P05164	details
Eosinophil peroxidase	EPX	17q23.1	P11678	details
Prolyl 4-hydroxylase subunit alpha-2	P4HA2	5q31	O15460	details
Prolyl 4-hydroxylase subunit alpha-1	P4HA1	10q21.3-q23.1	P13674	details
Acyl-CoA desaturase	SCD	10q24.31	O00767	details
Gamma-butyrobetaine dioxygenase	BBOX1	11p14.2	O75936	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	1p36.22	Q02809	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	PLOD2	3q24	O00469	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	7q22	O60568	details
Tryptophan 5-hydroxylase 1	TPH1	11p15.3-p14	P17752	details
Tryptophan 5-hydroxylase 2	TPH2	12q21.1	Q8IWU9	details
Flavin reductase (NADPH)	BLVRB	19q13.1-q13.2	P30043	details
Aconitate hydratase, mitochondrial	ACO2	22q13.2	Q99798	details
Cytoplasmic aconitate hydratase	ACO1	9p21.1	P21399	details
Dihydropyrimidine dehydrogenase [NADP(+)]	DPYD	1p22	Q12882	details
Inositol oxygenase	MIOX	22q13.3	Q9UGB7	details
4-hydroxyphenylpyruvate dioxygenase	HPD	12q24-qter	P32754	details
Homogentisate 1,2-dioxygenase	HGD	3q13.33	Q93099	details
Cysteine dioxygenase type 1	CDO1	5q23.2	Q16878	details
Arachidonate 5-lipoxygenase	ALOX5	10q11.2	P09917	details
Arachidonate 15-lipoxygenase B	ALOX15B	17p13.1	O15296	details
Arachidonate 12-lipoxygenase, 12S-type	ALOX12	17p13.1	P18054	details
Prostaglandin G/H synthase 2	PTGS2	1q25.2-q25.3	P35354	details
Prostaglandin G/H synthase 1	PTGS1	9q32-q33.3	P23219	details
Arachidonate 15-lipoxygenase	ALOX15	17p13.3	P16050	details
Cytochrome b-c1 complex subunit Rieske, mitochondrial	UQCRFS1	19q12	P47985	details
Protoporphyrinogen oxidase	PPOX	1q22	P50336	details
Aspartyl/asparaginyl beta-hydroxylase	ASPH	8q12.1	Q12797	details
Pantothenate kinase 2, mitochondrial	PANK2	20p13	Q9BZ23	details
Thiosulfate sulfurtransferase	TST	22q13.1	Q16762	details
Ferrochelatase, mitochondrial	FECH	18q21.3	P22830	details
Galactose-1-phosphate uridylyltransferase	GALT	9p13	P07902	details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial	NDUFB11		Q9NX14	details
3-hydroxyanthranilate 3,4-dioxygenase	HAAO	2p21	P46952	details
Beta,beta-carotene 15,15'-monooxygenase	BCMO1	16q23.2	Q9HAY6	details
Cytochrome c oxidase subunit 1	MT-CO1		P00395	details
Serine/threonine-protein phosphatase PP1-beta catalytic subunit	PPP1CB	2p23	P62140	details
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	PPP1CC	12q24.1-q24.2	P36873	details
Superoxide dismutase [Mn], mitochondrial	SOD2	6q25.3	P04179	details
Superoxide dismutase [Cu-Zn]	SOD1	21q22.11	P00441	details
Cysteine desulfurase, mitochondrial	NFS1	20q11.22	Q9Y697	details
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	PPP2CA	5q31.1	P67775	details
Cholesterol 25-hydroxylase	CH25H	10q23	O95992	details
Cytochrome b reductase 1	CYBRD1	2q31.1	Q53TN4	details
Arachidonate 12-lipoxygenase, 12R-type	ALOX12B	17p13.1	O75342	details
Extracellular superoxide dismutase [Cu-Zn]	SOD3	4p15.2	P08294	details
Trimethyllysine dioxygenase, mitochondrial	TMLHE	Xq28	Q9NVH6	details
Hydroxyacid-oxoacid transhydrogenase, mitochondrial	ADHFE1	8q13.1	Q8IWW8	details
Stearoyl-CoA desaturase 5	SCD5	4q21.22	Q86SK9	details
Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	8q23.1	Q7LG56	details
Mitochondrial intermediate peptidase	MIPEP	13q12	Q99797	details
Serine/threonine-protein phosphatase with EF-hands 1	PPEF1	Xp22	O14829	details
Serine/threonine-protein phosphatase with EF-hands 2	PPEF2	4q21.1	O14830	details
Metalloreductase STEAP3	STEAP3	2q14.2	Q658P3	details
Eukaryotic translation initiation factor 2-alpha kinase 1	EIF2AK1	7p22	Q9BQI3	details
Fatty acid 2-hydroxylase	FA2H	16q23	Q7L5A8	details
2-aminoethanethiol dioxygenase	ADO	10q21.3	Q96SZ5	details
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2	ALKBH2	12q24.11	Q6NS38	details
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3	ALKBH3	11p11.2	Q96Q83	details
Beta,beta-carotene 9',10'-oxygenase	BCO2	11q23.1	Q9BYV7	details
Probable imidazolonepropionase	AMDHD1	12q23.1	Q96NU7	details
Epidermis-type lipoxygenase 3	ALOXE3	17p13.1	Q9BYJ1	details
Prolyl 3-hydroxylase 1	LEPRE1	1p34.1	Q32P28	details
Prolyl 3-hydroxylase 2	LEPREL1	3q28	Q8IVL5	details
Prolyl 3-hydroxylase 3	LEPREL2	12q13	Q8IVL6	details
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	PPP1CA	11q13	P62136	details
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	PPP2CB	8p12	P62714	details
Serine/threonine-protein phosphatase 4 catalytic subunit	PPP4C	16p11.2	P60510	details
Serine/threonine-protein phosphatase 5	PPP5C	19q13.3	P53041	details
Serine/threonine-protein phosphatase 6 catalytic subunit	PPP6C	9q33.3	O00743	details
Transmembrane protease serine 6	TMPRSS6	22q12.3	Q8IU80	details
Prolyl 4-hydroxylase subunit alpha-3	P4HA3	11q13.4	Q7Z4N8	details
NADH dehydrogenase (Ubiquinone) 1 beta subcomplex, 2, 8kDa	NDUFB2	7q34	A4D1T5	details
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1	OGFOD1	16q12.2	Q8N543	details
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2	OGFOD2	12q24.31	Q6N063	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	19p13.3	Q86Y39	details
Acyl carrier protein, mitochondrial	NDUFAB1	16p12.2	O14561	details
Cytochrome b-c1 complex subunit Rieske, mitochondrial	UQCRFS1	19q12	P47985	details
Solute carrier family 40 member 1	SLC40A1	2q32	Q9NP59	details
Natural resistance-associated macrophage protein 2	SLC11A2	12q13	P49281	details
Cubilin	CUBN	10p12.31	O60494	details
Proton-coupled folate transporter	SLC46A1	17q11.2	Q96NT5	details
Cytochrome b-c1 complex subunit 10	UQCR11	19p13.3	O14957	details
ATP-binding cassette sub-family B member 7, mitochondrial	ABCB7		O75027	details
Natural resistance-associated macrophage protein 1	SLC11A1	2q35	P49279	details
Zinc transporter ZIP14	SLC39A14	8p21.3	Q15043	details
Sideroflexin-1	SFXN1		Q9H9B4	details
Sideroflexin-2	SFXN2	10q24.32	Q96NB2	details
Sideroflexin-3	SFXN3	10q24.31	Q9BWM7	details
Sideroflexin-4	SFXN4	10q26.11	Q6P4A7	details
Sideroflexin-5	SFXN5		Q8TD22	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Ribonucleoside-diphosphate reductase subunit M2	RRM2	2p25-p24	P31350	details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	1q23	O75306	details
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	1q23.3	Q99643	details
Lathosterol oxidase	SC5DL	11q23.3	O75845	details
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	18p11.22	P19404	details
Heme oxygenase 2	HMOX2	16p13.3	P30519	details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	11q13	O00217	details
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	2q33-q34	P28331	details
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial	ETFDH	4q32-q35	Q16134	details
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	11q23	O14521	details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	19p13.3	O75251	details
Xanthine dehydrogenase/oxidase	XDH	2p23.1	P47989	details
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	11q13	P49821	details
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	1p36.1-p35	P21912	details
Heme oxygenase 1	HMOX1	22q13.1	P09601	details
Methylsterol monooxygenase 1	MSMO1	4q32-q34	Q15800	details
Phytanoyl-CoA dioxygenase, peroxisomal	PHYH	10p13	O14832	details
Tyrosine 3-monooxygenase	TH	11p15.5	P07101	details
Thyroid peroxidase	TPO	2p25	P07202	details
Lactoperoxidase	LPO	17q23.1	P22079	details
Phenylalanine-4-hydroxylase	PAH	12q22-q24.2	P00439	details
Myeloperoxidase	MPO	17q23.1	P05164	details
Eosinophil peroxidase	EPX	17q23.1	P11678	details
Prolyl 4-hydroxylase subunit alpha-2	P4HA2	5q31	O15460	details
Prolyl 4-hydroxylase subunit alpha-1	P4HA1	10q21.3-q23.1	P13674	details
Acyl-CoA desaturase	SCD	10q24.31	O00767	details
Gamma-butyrobetaine dioxygenase	BBOX1	11p14.2	O75936	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	1p36.22	Q02809	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	PLOD2	3q24	O00469	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	7q22	O60568	details
Tryptophan 5-hydroxylase 1	TPH1	11p15.3-p14	P17752	details
Ferritin, mitochondrial	FTMT	5q21.3	Q8N4E7	details
Tryptophan 5-hydroxylase 2	TPH2	12q21.1	Q8IWU9	details
Ceruloplasmin	CP	3q23-q25	P00450	details
Cytoplasmic aconitate hydratase	ACO1	9p21.1	P21399	details
Dihydropyrimidine dehydrogenase [NADP(+)]	DPYD	1p22	Q12882	details
Inositol oxygenase	MIOX	22q13.3	Q9UGB7	details
4-hydroxyphenylpyruvate dioxygenase	HPD	12q24-qter	P32754	details
Homogentisate 1,2-dioxygenase	HGD	3q13.33	Q93099	details
Cysteine dioxygenase type 1	CDO1	5q23.2	Q16878	details
Arachidonate 5-lipoxygenase	ALOX5	10q11.2	P09917	details
Arachidonate 15-lipoxygenase B	ALOX15B	17p13.1	O15296	details
Arachidonate 12-lipoxygenase, 12S-type	ALOX12	17p13.1	P18054	details
Prostaglandin G/H synthase 2	PTGS2	1q25.2-q25.3	P35354	details
Prostaglandin G/H synthase 1	PTGS1	9q32-q33.3	P23219	details
Arachidonate 15-lipoxygenase	ALOX15	17p13.3	P16050	details
Cytochrome b-c1 complex subunit Rieske, mitochondrial	UQCRFS1	19q12	P47985	details
Galactose-1-phosphate uridylyltransferase	GALT	9p13	P07902	details
3-hydroxyanthranilate 3,4-dioxygenase	HAAO	2p21	P46952	details
Beta,beta-carotene 15,15'-monooxygenase	BCMO1	16q23.2	Q9HAY6	details
Hemoglobin subunit alpha	HBA1	16p13.3	P69905	details
Cytochrome c oxidase subunit 1	MT-CO1		P00395	details
Ubiquinone biosynthesis protein COQ7 homolog	COQ7		Q99807	details
Serine/threonine-protein phosphatase PP1-beta catalytic subunit	PPP1CB	2p23	P62140	details
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	PPP1CC	12q24.1-q24.2	P36873	details
Superoxide dismutase [Mn], mitochondrial	SOD2	6q25.3	P04179	details
Lactotransferrin	LTF	3p21.31	P02788	details
Superoxide dismutase [Cu-Zn]	SOD1	21q22.11	P00441	details
Serotransferrin	TF	3q22.1	P02787	details
Ferritin light chain	FTL	19q13.33	P02792	details
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	PPP2CA	5q31.1	P67775	details
Cubilin	CUBN	10p12.31	O60494	details
Cholesterol 25-hydroxylase	CH25H	10q23	O95992	details
Arachidonate 12-lipoxygenase, 12R-type	ALOX12B	17p13.1	O75342	details
Extracellular superoxide dismutase [Cu-Zn]	SOD3	4p15.2	P08294	details
Trimethyllysine dioxygenase, mitochondrial	TMLHE	Xq28	Q9NVH6	details
Hydroxyacid-oxoacid transhydrogenase, mitochondrial	ADHFE1	8q13.1	Q8IWW8	details
Stearoyl-CoA desaturase 5	SCD5	4q21.22	Q86SK9	details
Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	8q23.1	Q7LG56	details
Serine/threonine-protein phosphatase with EF-hands 1	PPEF1	Xp22	O14829	details
Serine/threonine-protein phosphatase with EF-hands 2	PPEF2	4q21.1	O14830	details
Peroxidasin homolog	PXDN	2p25	Q92626	details
Peroxidasin-like protein	PXDNL	8q11.22-q11.23	A1KZ92	details
Hephaestin	HEPH		Q9BQS7	details
Metalloreductase STEAP3	STEAP3	2q14.2	Q658P3	details
Fatty acid 2-hydroxylase	FA2H	16q23	Q7L5A8	details
Neudesin	NENF	1q32.3	Q9UMX5	details
Membrane-associated progesterone receptor component 1	PGRMC1		O00264	details
Membrane-associated progesterone receptor component 2	PGRMC2	4q26	O15173	details
2-aminoethanethiol dioxygenase	ADO	10q21.3	Q96SZ5	details
Beta,beta-carotene 9',10'-oxygenase	BCO2	11q23.1	Q9BYV7	details
Ferritin heavy chain	FTH1	11q13	P02794	details
Probable imidazolonepropionase	AMDHD1	12q23.1	Q96NU7	details
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial	ISCU	12q24.1	Q9H1K1	details
Epidermis-type lipoxygenase 3	ALOXE3	17p13.1	Q9BYJ1	details
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial	NFU1	2p15-p13	Q9UMS0	details
Prolyl 3-hydroxylase 1	LEPRE1	1p34.1	Q32P28	details
Prolyl 3-hydroxylase 2	LEPREL1	3q28	Q8IVL5	details
Prolyl 3-hydroxylase 3	LEPREL2	12q13	Q8IVL6	details
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	PPP1CA	11q13	P62136	details
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	PPP2CB	8p12	P62714	details
Serine/threonine-protein phosphatase 4 catalytic subunit	PPP4C	16p11.2	P60510	details
Serine/threonine-protein phosphatase 5	PPP5C	19q13.3	P53041	details
Serine/threonine-protein phosphatase 6 catalytic subunit	PPP6C	9q33.3	O00743	details
Melanotransferrin	MFI2	3q28-q29	P08582	details
Prolyl 4-hydroxylase subunit alpha-3	P4HA3	11q13.4	Q7Z4N8	details
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1	OGFOD1	16q12.2	Q8N543	details
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2	OGFOD2	12q24.31	Q6N063	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Tyrosine 3-monooxygenase	TH	11p15.5	P07101	details
Ubiquitin-conjugating enzyme E2 D1	UBE2D1	10q21.1	P51668	details
Prostaglandin G/H synthase 1	PTGS1	9q32-q33.3	P23219	details
Serine/threonine-protein phosphatase PP1-beta catalytic subunit	PPP1CB	2p23	P62140	details
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	PPP1CC	12q24.1-q24.2	P36873	details
Superoxide dismutase [Cu-Zn]	SOD1	21q22.11	P00441	details
Transferrin receptor protein 2	TFR2	7q22	Q9UP52	details
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	PPP2CA	5q31.1	P67775	details
Transferrin receptor protein 1	TFRC	3q29	P02786	details
Scavenger receptor cysteine-rich type 1 protein M130	CD163	12p13.3	Q86VB7	details
Intelectin-1	ITLN1	1q21.3	Q8WWA0	details
Serine/threonine-protein phosphatase with EF-hands 2	PPEF2	4q21.1	O14830	details
Peroxidasin homolog	PXDN	2p25	Q92626	details
Membrane-associated progesterone receptor component 1	PGRMC1		O00264	details
Membrane-associated progesterone receptor component 2	PGRMC2	4q26	O15173	details
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	PPP1CA	11q13	P62136	details
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	PPP2CB	8p12	P62714	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Ribonucleoside-diphosphate reductase subunit M2	RRM2	2p25-p24	P31350	details
Heme oxygenase 1	HMOX1	22q13.1	P09601	details
Ubiquitin-conjugating enzyme E2 D1	UBE2D1	10q21.1	P51668	details
Aspartyl/asparaginyl beta-hydroxylase	ASPH	8q12.1	Q12797	details
Hypoxia-inducible factor 1-alpha inhibitor	HIF1AN	10q24	Q9NWT6	details
Superoxide dismutase [Mn], mitochondrial	SOD2	6q25.3	P04179	details
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	PPP2CA	5q31.1	P67775	details
Transcription factor NF-E2 45 kDa subunit	NFE2	12q13	Q16621	details
Serine/threonine-protein phosphatase 5	PPP5C	19q13.3	P53041	details

Concentrations Data

Cannabis Cultivar	Status	Value	Reference	Details
Alien Dawg	Detected and Quantified	0.195 mg/g dry wt	David S. Wishart,...	details
Gabriola	Detected and Quantified	0.297 mg/g dry wt	David S. Wishart,...	details
Island Honey	Detected and Quantified	0.198 mg/g dry wt	David S. Wishart,...	details
Quadra	Detected and Quantified	0.217 mg/g dry wt	David S. Wishart,...	details
Sensi Star	Detected and Quantified	0.098 mg/g dry wt	David S. Wishart,...	details
Tangerine Dream	Detected and Quantified	0.087 mg/g dry wt	David S. Wishart,...	details

External Links

HMDB ID

HMDB0015531

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

FDB030855

KNApSAcK ID

Not Available

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

Not Available

PubChem Compound

27284

PDB ID

FE2

ChEBI ID

29033

References

General References

Not Available

Only showing the first 10 proteins. There are 274 proteins in total.

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Enzymes

Enzyme Details

1. 5-aminolevulinate synthase, erythroid-specific, mitochondrial

General function:: Involved in 5-aminolevulinate synthase activity
Specific function:: Not Available
Gene Name:: ALAS2
Uniprot ID:: P22557
Molecular weight:: 64632.86

Enzyme Details

2. 85/88 kDa calcium-independent phospholipase A2

General function:: Involved in metabolic process
Specific function:: Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods. Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.
Gene Name:: PLA2G6
Uniprot ID:: O60733
Molecular weight:: 84092.635

Enzyme Details

3. Tartrate-resistant acid phosphatase type 5

General function:: Involved in hydrolase activity
Specific function:: Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.
Gene Name:: ACP5
Uniprot ID:: P13686
Molecular weight:: 36598.47

Enzyme Details

4. Ribonucleoside-diphosphate reductase large subunit

General function:: Involved in oxidation reduction
Specific function:: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Gene Name:: RRM1
Uniprot ID:: P23921
Molecular weight:: 90069.375

Enzyme Details

5. Ribonucleoside-diphosphate reductase subunit M2

General function:: Involved in oxidoreductase activity
Specific function:: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
Gene Name:: RRM2
Uniprot ID:: P31350
Molecular weight:: 44877.25

Enzyme Details

6. NADH-ubiquinone oxidoreductase chain 1

General function:: Involved in oxidation reduction
Specific function:: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Gene Name:: MT-ND1
Uniprot ID:: P03886
Molecular weight:: 35660.055

Enzyme Details

7. NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

General function:: Involved in NADH dehydrogenase activity
Specific function:: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Gene Name:: NDUFB1
Uniprot ID:: O75438
Molecular weight:: 6961.2

Enzyme Details

8. NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

General function:: Involved in oxidoreductase activity, acting on NADH or NADPH
Specific function:: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Gene Name:: NDUFS2
Uniprot ID:: O75306
Molecular weight:: 51851.59

Enzyme Details

9. Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

General function:: Involved in succinate dehydrogenase activity
Specific function:: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Gene Name:: SDHC
Uniprot ID:: Q99643
Molecular weight:: 16650.185

Enzyme Details

10. Peroxisomal N(1)-acetyl-spermine/spermidine oxidase

General function:: Amino acid transport and metabolism
Specific function:: Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.
Gene Name:: PAOX
Uniprot ID:: Q6QHF9
Molecular weight:: 55512.64

Transporters

Enzyme Details

1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

General function:: Involved in protein transporter activity
Specific function:: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Gene Name:: NDUFA11
Uniprot ID:: Q86Y39
Molecular weight:: 14852.0

Enzyme Details

2. Acyl carrier protein, mitochondrial

General function:: Involved in acyl carrier activity
Specific function:: Carrier of the growing fatty acid chain in fatty acid biosynthesis in mitochondria. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain
Gene Name:: NDUFAB1
Uniprot ID:: O14561
Molecular weight:: 17417.1

Enzyme Details

3. Cytochrome b-c1 complex subunit Rieske, mitochondrial

General function:: Involved in oxidoreductase activity
Specific function:: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be the subunit 11/IX of that complex (By similarity).
Gene Name:: UQCRFS1
Uniprot ID:: P47985
Molecular weight:: 29667.695

Enzyme Details

4. Solute carrier family 40 member 1

General function:: Involved in iron ion transmembrane transporter activity
Specific function:: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin)
Gene Name:: SLC40A1
Uniprot ID:: Q9NP59
Molecular weight:: 62541.6

Enzyme Details

5. Natural resistance-associated macrophage protein 2

General function:: Involved in transporter activity
Specific function:: Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution
Gene Name:: SLC11A2
Uniprot ID:: P49281
Molecular weight:: 62265.2

Enzyme Details

6. Cubilin

General function:: Involved in calcium ion binding
Specific function:: Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands required calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface
Gene Name:: CUBN
Uniprot ID:: O60494
Molecular weight:: 398672.8

Enzyme Details

7. Proton-coupled folate transporter

General function:: Involved in transmembrane transport
Specific function:: Has been shown to act both as an intestinal proton- coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme
Gene Name:: SLC46A1
Uniprot ID:: Q96NT5
Molecular weight:: 49770.0

Enzyme Details

8. Cytochrome b-c1 complex subunit 10

General function:: Involved in ubiquinol-cytochrome-c reductase activity
Specific function:: This protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor
Gene Name:: UQCR11
Uniprot ID:: O14957
Molecular weight:: 6569.7

Enzyme Details

9. ATP-binding cassette sub-family B member 7, mitochondrial

General function:: Involved in ATP binding
Specific function:: Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins
Gene Name:: ABCB7
Uniprot ID:: O75027
Molecular weight:: 82640.6

Enzyme Details

10. Natural resistance-associated macrophage protein 1

General function:: Involved in transporter activity
Specific function:: Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes
Gene Name:: SLC11A1
Uniprot ID:: P49279
Molecular weight:: 59871.6

Only showing the first 10 proteins. There are 274 proteins in total.

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Showing Compound Card for Iron (CDB005174)

Structure for CDB005174 (Iron)

Enzymes

Transporters