Identification |
HMDB Protein ID
| CDBP00454 |
Secondary Accession Numbers
| Not Available |
Name
| Tryptophan 5-hydroxylase 2 |
Description
| Not Available |
Synonyms
|
- Neuronal tryptophan hydroxylase
- Tryptophan 5-monooxygenase 2
|
Gene Name
| TPH2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in amino acid binding |
Specific Function
| Not Available |
GO Classification
|
Biological Process |
cellular response to lithium ion |
response to stress |
serotonin biosynthetic process |
response to calcium ion |
aromatic amino acid family metabolic process |
response to glucocorticoid stimulus |
response to nutrient levels |
response to activity |
circadian rhythm |
response to estrogen stimulus |
small molecule metabolic process |
indolalkylamine biosynthetic process |
Cellular Component |
cytosol |
neuron projection |
Function |
catalytic activity |
transition metal ion binding |
iron ion binding |
monooxygenase activity |
carboxylic acid binding |
amino acid binding |
oxidoreductase activity |
tryptophan 5-monooxygenase activity |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen |
ion binding |
cation binding |
metal ion binding |
binding |
Molecular Function |
tryptophan 5-monooxygenase activity |
iron ion binding |
amino acid binding |
Process |
cellular amino acid derivative metabolic process |
cellular biogenic amine metabolic process |
cellular amino acid and derivative metabolic process |
cellular amino acid metabolic process |
serotonin metabolic process |
serotonin biosynthetic process |
aromatic amino acid family metabolic process |
metabolic process |
indolalkylamine metabolic process |
cellular metabolic process |
oxidation reduction |
|
Cellular Location
|
Not Available
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | serotonin biosynthesis | Not Available | Not Available | Serotonergic synapse | Not Available | ![Map04726](https://www.genome.jp/kegg/misc/thumbnail/map04726.gif) |
|
Gene Properties |
Chromosome Location
| 12 |
Locus
| 12q21.1 |
SNPs
| TPH2 |
Gene Sequence
|
>1473 bp
ATGCAGCCAGCAATGATGATGTTTTCCAGTAAATACTGGGCACGGAGAGGGTTTTCCCTG
GATTCAGCAGTGCCCGAAGAGCATCAGCTACTTGGCAGCTCAACACTAAATAAACCTAAC
TCTGGCAAAAATGACGACAAAGGCAACAAGGGAAGCAGCAAACGTGAAGCTGCTACCGAA
AGTGGCAAGACAGCAGTTGTTTTCTCCTTGAAGAATGAAGTTGGTGGATTGGTAAAAGCA
CTGAGGCTCTTTCAGGAAAAACGTGTCAACATGGTTCATATTGAATCCAGGAAATCTCGG
CGAAGAAGTTCTGAGGTTGAAATCTTTGTGGACTGTGAGTGTGGGAAAACAGAATTCAAT
GAGCTCATTCAGTTGCTGAAATTTCAAACCACTATTGTGACGCTGAATCCTCCAGAGAAC
ATTTGGACAGAGGAAGAAGAGCTAGAGGATGTGCCCTGGTTCCCTCGGAAGATCTCTGAG
TTAGACAAATGCTCTCACAGAGTTCTCATGTATGGTTCTGAGCTTGATGCTGACCACCCA
GGATTTAAGGACAATGTCTATCGACAGAGAAGAAAGTATTTTGTGGATGTGGCCATGGGT
TATAAATATGGTCAGCCCATTCCCAGGGTGGAGTATACTGAAGAAGAAACTAAAACTTGG
GGTGTTGTATTCCGGGAGCTCTCCAAACTCTATCCCACTCATGCTTGCCGAGAGTATTTG
AAAAACTTCCCTCTGCTGACTAAATACTGTGGCTACAGAGAGGACAATGTGCCTCAACTC
GAAGATGTCTCCATGTTTCTGAAAGAAAGGTCTGGCTTCACGGTGAGGCCGGTGGCTGGA
TACCTGAGCCCACGAGACTTTCTGGCAGGACTGGCCTACAGAGTGTTCCACTGTACCCAG
TACATCCGGCATGGCTCAGATCCCCTCTACACCCCAGAACCAGACACATGCCATGAACTC
TTGGGACATGTTCCACTACTTGCGGATCCTAAGTTTGCTCAGTTTTCACAAGAAATAGGT
CTGGCGTCTCTGGGAGCATCAGATGAAGATGTTCAGAAACTAGCCACGTGCTATTTCTTC
ACAATCGAGTTTGGCCTTTGCAAGCAAGAAGGGCAACTGCGGGCATATGGAGCAGGACTC
CTTTCCTCCATTGGAGAATTAAAGCACGCCCTTTCTGACAAGGCATGTGTGAAAGCCTTT
GACCCAAAGACAACTTGCTTACAGGAATGCCTTATCACCACCTTCCAGGAAGCCTACTTT
GTTTCAGAAAGTTTTGAAGAAGCCAAAGAAAAGATGAGGGACTTTGCAAAGTCAATTACC
CGTCCCTTCTCAGTATACTTCAATCCCTACACACAGAGTATTGAAATTCTGAAAGACACC
AGAAGTATTGAAAATGTGGTGCAGGACCTTCGCAGCGACTTGAATACAGTGTGTGATGCT
TTAAACAAAATGAACCAATATCTGGGGATTTGA
|
Protein Properties |
Number of Residues
| 490 |
Molecular Weight
| 56056.295 |
Theoretical pI
| 6.415 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Tryptophan 5-hydroxylase 2
MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKNDDKGNKGSSKREAATE
SGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFN
ELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHP
GFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYL
KNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQ
YIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFF
TIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYF
VSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDA
LNKMNQYLGI
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| Q8IWU9 |
UniProtKB/Swiss-Prot Entry Name
| TPH2_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AY098914 |
GeneCard ID
| TPH2 |
GenAtlas ID
| TPH2 |
HGNC ID
| HGNC:20692 |
References |
General References
| Not Available |