| Identification |
|---|
| HMDB Protein ID
| CDBP00454 |
| Secondary Accession Numbers
| Not Available |
| Name
| Tryptophan 5-hydroxylase 2 |
| Description
| Not Available |
| Synonyms
|
- Neuronal tryptophan hydroxylase
- Tryptophan 5-monooxygenase 2
|
| Gene Name
| TPH2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in amino acid binding |
| Specific Function
| Not Available |
| GO Classification
|
| Biological Process |
| cellular response to lithium ion |
| response to stress |
| serotonin biosynthetic process |
| response to calcium ion |
| aromatic amino acid family metabolic process |
| response to glucocorticoid stimulus |
| response to nutrient levels |
| response to activity |
| circadian rhythm |
| response to estrogen stimulus |
| small molecule metabolic process |
| indolalkylamine biosynthetic process |
| Cellular Component |
| cytosol |
| neuron projection |
| Function |
| catalytic activity |
| transition metal ion binding |
| iron ion binding |
| monooxygenase activity |
| carboxylic acid binding |
| amino acid binding |
| oxidoreductase activity |
| tryptophan 5-monooxygenase activity |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| Molecular Function |
| tryptophan 5-monooxygenase activity |
| iron ion binding |
| amino acid binding |
| Process |
| cellular amino acid derivative metabolic process |
| cellular biogenic amine metabolic process |
| cellular amino acid and derivative metabolic process |
| cellular amino acid metabolic process |
| serotonin metabolic process |
| serotonin biosynthetic process |
| aromatic amino acid family metabolic process |
| metabolic process |
| indolalkylamine metabolic process |
| cellular metabolic process |
| oxidation reduction |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | serotonin biosynthesis | Not Available | Not Available | | Serotonergic synapse | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12q21.1 |
| SNPs
| TPH2 |
| Gene Sequence
|
>1473 bp
ATGCAGCCAGCAATGATGATGTTTTCCAGTAAATACTGGGCACGGAGAGGGTTTTCCCTG
GATTCAGCAGTGCCCGAAGAGCATCAGCTACTTGGCAGCTCAACACTAAATAAACCTAAC
TCTGGCAAAAATGACGACAAAGGCAACAAGGGAAGCAGCAAACGTGAAGCTGCTACCGAA
AGTGGCAAGACAGCAGTTGTTTTCTCCTTGAAGAATGAAGTTGGTGGATTGGTAAAAGCA
CTGAGGCTCTTTCAGGAAAAACGTGTCAACATGGTTCATATTGAATCCAGGAAATCTCGG
CGAAGAAGTTCTGAGGTTGAAATCTTTGTGGACTGTGAGTGTGGGAAAACAGAATTCAAT
GAGCTCATTCAGTTGCTGAAATTTCAAACCACTATTGTGACGCTGAATCCTCCAGAGAAC
ATTTGGACAGAGGAAGAAGAGCTAGAGGATGTGCCCTGGTTCCCTCGGAAGATCTCTGAG
TTAGACAAATGCTCTCACAGAGTTCTCATGTATGGTTCTGAGCTTGATGCTGACCACCCA
GGATTTAAGGACAATGTCTATCGACAGAGAAGAAAGTATTTTGTGGATGTGGCCATGGGT
TATAAATATGGTCAGCCCATTCCCAGGGTGGAGTATACTGAAGAAGAAACTAAAACTTGG
GGTGTTGTATTCCGGGAGCTCTCCAAACTCTATCCCACTCATGCTTGCCGAGAGTATTTG
AAAAACTTCCCTCTGCTGACTAAATACTGTGGCTACAGAGAGGACAATGTGCCTCAACTC
GAAGATGTCTCCATGTTTCTGAAAGAAAGGTCTGGCTTCACGGTGAGGCCGGTGGCTGGA
TACCTGAGCCCACGAGACTTTCTGGCAGGACTGGCCTACAGAGTGTTCCACTGTACCCAG
TACATCCGGCATGGCTCAGATCCCCTCTACACCCCAGAACCAGACACATGCCATGAACTC
TTGGGACATGTTCCACTACTTGCGGATCCTAAGTTTGCTCAGTTTTCACAAGAAATAGGT
CTGGCGTCTCTGGGAGCATCAGATGAAGATGTTCAGAAACTAGCCACGTGCTATTTCTTC
ACAATCGAGTTTGGCCTTTGCAAGCAAGAAGGGCAACTGCGGGCATATGGAGCAGGACTC
CTTTCCTCCATTGGAGAATTAAAGCACGCCCTTTCTGACAAGGCATGTGTGAAAGCCTTT
GACCCAAAGACAACTTGCTTACAGGAATGCCTTATCACCACCTTCCAGGAAGCCTACTTT
GTTTCAGAAAGTTTTGAAGAAGCCAAAGAAAAGATGAGGGACTTTGCAAAGTCAATTACC
CGTCCCTTCTCAGTATACTTCAATCCCTACACACAGAGTATTGAAATTCTGAAAGACACC
AGAAGTATTGAAAATGTGGTGCAGGACCTTCGCAGCGACTTGAATACAGTGTGTGATGCT
TTAAACAAAATGAACCAATATCTGGGGATTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 490 |
| Molecular Weight
| 56056.295 |
| Theoretical pI
| 6.415 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Tryptophan 5-hydroxylase 2
MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKNDDKGNKGSSKREAATE
SGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFN
ELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHP
GFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYL
KNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQ
YIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFF
TIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYF
VSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDA
LNKMNQYLGI
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q8IWU9 |
| UniProtKB/Swiss-Prot Entry Name
| TPH2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY098914 |
| GeneCard ID
| TPH2 |
| GenAtlas ID
| TPH2 |
| HGNC ID
| HGNC:20692 |
| References |
|---|
| General References
| Not Available |