| Identification |
|---|
| HMDB Protein ID
| CDBP03908 |
| Secondary Accession Numbers
| Not Available |
| Name
| Melanotransferrin |
| Description
| Not Available |
| Synonyms
|
- CD228 antigen
- Melanoma-associated antigen p97
|
| Gene Name
| MFI2 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in ferric iron binding |
| Specific Function
| Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc |
| GO Classification
|
| Component |
| extracellular region |
| Function |
| transition metal ion binding |
| iron ion binding |
| ferric iron binding |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| Process |
| cellular cation homeostasis |
| cellular di-, tri-valent inorganic cation homeostasis |
| cellular iron ion homeostasis |
| establishment of localization |
| transport |
| biological regulation |
| ion transport |
| cation transport |
| metal ion transport |
| transition metal ion transport |
| iron ion transport |
| regulation of biological quality |
| homeostatic process |
| chemical homeostasis |
| ion homeostasis |
| cellular ion homeostasis |
|
| Cellular Location
|
- Lipid-anchor
- GPI- anchor
- Isoform 1:Cell membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3q28-q29 |
| SNPs
| MFI2 |
| Gene Sequence
|
>2217 bp
ATGCGGGGTCCGAGCGGGGCTCTGTGGCTGCTCCTGGCTCTGCGCACCGTGCTCGGTGGC
ATGGAGGTGCGGTGGTGCGCCACCTCGGACCCAGAGCAGCACAAGTGCGGCAACATGAGC
GAGGCCTTCCGGGAAGCGGGCATCCAGCCCTCCCTCCTCTGCGTCCGGGGCACCTCCGCC
GACCACTGCGTCCAGCTCATCGCGGCCCAGGAGGCTGACGCCATCACTCTGGATGGAGGA
GCCATCTATGAGGCGGGAAAGGAGCACGGCCTGAAGCCGGTGGTGGGCGAAGTGTACGAT
CAAGAGGTCGGTACCTCCTATTACGCCGTGGCTGTGGTCAGGAGGAGCTCCCATGTGACC
ATTGACACCCTGAAAGGCGTGAAGTCCTGCCACACGGGCATCAATCGCACAGTGGGCTGG
AACGTGCCCGTGGGCTACCTGGTGGAGAGCGGCCGCCTCTCGGTGATGGGCTGCGATGTA
CTCAAAGCTGTCAGCGACTATTTTGGGGGCAGCTGCGTCCCGGGGGCAGGAGAGACCAGT
TACTCTGAGTCCCTCTGTCGCCTCTGCAGGGGTGACAGCTCTGGGGAAGGGGTGTGTGAC
AAGAGCCCCCTGGAGAGATACTACGACTACAGCGGGGCCTTCCGGTGCCTGGCGGAAGGG
GCAGGGGACGTGGCTTTTGTGAAGCACAGCACGGTACTGGAGAACACGGATGGGAAGACG
CTTCCCTCCTGGGGCCAGGCCCTGCTGTCACAGGACTTCGAGCTGCTGTGCCGGGATGGT
AGCCGGGCCGATGTCACCGAGTGGAGGCAGTGCCATCTGGCCCGGGTGCCTGCTCACGCC
GTGGTGGTCCGGGCCGACACAGATGGGGGCCTCATCTTCCGGCTGCTCAACGAAGGCCAG
CGTCTGTTCAGCCACGAGGGCAGCAGCTTCCAGATGTTCAGCTCTGAGGCCTATGGCCAG
AAGGATCTACTCTTCAAAGACTCTACCTCGGAGCTTGTGCCCATCGCCACACAGACCTAT
GAGGCGTGGCTGGGCCATGAGTACCTGCACGCCATGAAGGGTCTGCTCTGTGACCCCAAC
CGGCTGCCCCCCTACCTGCGCTGGTGTGTGCTCTCCACTCCCGAGATCCAGAAGTGTGGA
GACATGGCCGTGGCCTTCCGCCGGCAGCGGCTCAAGCCAGAGATCCAGTGCGTGTCAGCC
AAGTCCCCCCAACACTGCATGGAGCGGATCCAGGCTGAGCAGGTCGACGCTGTGACCCTG
AGTGGCGAGGACATTTACACGGCGGGGAAGACGTACGGCCTGGTTCCCGCAGCCGGGGAG
CACTATGCCCCGGAAGACAGCAGCAACTCGTACTACGTGGTGGCCGTGGTGAGACGGGAC
AGCTCCCACGCCTTCACCTTGGATGAGCTTCGGGGCAAGCGCTCCTGCCACGCCGGTTTC
GGCAGCCCTGCAGGCTGGGATGTCCCCGTGGGTGCCCTTATTCAGAGAGGCTTCATCCGG
CCCAAGGACTGTGACGTCCTCACAGCAGTGAGCGAGTTCTTCAATGCCAGCTGCGTGCCC
GTGAACAACCCCAAGAACTACCCCTCCTCGCTGTGTGCACTGTGCGTGGGGGACGAGCAG
GGCCGCAACAAGTGTGTGGGCAACAGCCAGGAGCGGTATTACGGCTACCGCGGCGCCTTC
AGGTGCCTGGTGGAGAATGCGGGTGACGTTGCCTTCGTCAGGCACACAACCGTCTTTGAC
AACACAAACGGCCACAATTCCGAGCCCTGGGCTGCTGAGCTCAGGTCAGAGGACTATGAA
CTGCTGTGCCCCAACGGGGCCCGAGCCGAGGTGTCCCAGTTTGCAGCCTGCAACCTGGCA
CAGATACCACCCCACGCCGTGATGGTCCGGCCCGACACCAACATCTTCACCGTGTATGGA
CTGCTGGACAAGGCCCAGGACCTGTTTGGAGACGACCACAATAAGAACGGGTTCAAAATG
TTCGACTCCTCCAACTATCATGGCCAAGACCTGCTTTTCAAGGATGCCACCGTCCGGGCG
GTGCCTGTCGGAGAGAAAACCACCTACCGCGGCTGGCTGGGGCTGGACTACGTGGCGGCG
CTGGAAGGGATGTCGTCTCAGCAGTGCTCGGGCGCAGCGGCCCCGGCGCCCGGGGCGCCC
CTGCTCCCGCTGCTGCTGCCCGCCCTCGCCGCCCGCCTGCTCCCGCCCGCCCTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 738 |
| Molecular Weight
| 80240.9 |
| Theoretical pI
| 5.9 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Melanotransferrin
MRGPSGALWLLLALRTVLGGMEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLCVRGTSA
DHCVQLIAAQEADAITLDGGAIYEAGKEHGLKPVVGEVYDQEVGTSYYAVAVVRRSSHVT
IDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDYFGGSCVPGAGETS
YSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDGKT
LPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVRADTDGGLIFRLLNEGQ
RLFSHEGSSFQMFSSEAYGQKDLLFKDSTSELVPIATQTYEAWLGHEYLHAMKGLLCDPN
RLPPYLRWCVLSTPEIQKCGDMAVAFRRQRLKPEIQCVSAKSPQHCMERIQAEQVDAVTL
SGEDIYTAGKKYGLVPAAGEHYAPEDSSNSYYVVAVVRRDSSHAFTLDELRGKRSCHAGF
GSPAGWDVPVGALIQRGFIRPKDCDVLTAVSEFFNASCVPVNNPKNYPSSLCALCVGDEQ
GRNKCVGNSQERYYGYRGAFRCLVENAGDVAFVRHTTVFDNTNGHNSEPWAAELRSEDYE
LLCPNGARAEVSQFAACNLAQIPPHAVMVRPDTNIFTVYGLLDKAQDLFGDDHNKNGFKM
FDSSNYHGQDLLFKDATVRAVPVGEKTTYRGWLGLDYVAALEGMSSQQCSGAAAPAPGAP
LLPLLLPALAARLLPPAL
|
| External Links |
|---|
| GenBank ID Protein
| 134244281 |
| UniProtKB/Swiss-Prot ID
| P08582 |
| UniProtKB/Swiss-Prot Entry Name
| TRFM_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_005929.5 |
| GeneCard ID
| MFI2 |
| GenAtlas ID
| MFI2 |
| HGNC ID
| HGNC:7037 |
| References |
|---|
| General References
| Not Available |