| Identification |
|---|
| HMDB Protein ID
| CDBP01773 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ferritin light chain |
| Description
| Not Available |
| Synonyms
|
- Ferritin L subunit
|
| Gene Name
| FTL |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| iron ion binding |
| oxidoreductase activity |
| ferric iron binding |
| Process |
| biological regulation |
| oxidation reduction |
| ion transport |
| cation transport |
| metal ion transport |
| transition metal ion transport |
| iron ion transport |
| regulation of biological quality |
| homeostatic process |
| chemical homeostasis |
| ion homeostasis |
| cellular ion homeostasis |
| cellular cation homeostasis |
| metabolic process |
| cellular di-, tri-valent inorganic cation homeostasis |
| establishment of localization |
| cellular iron ion homeostasis |
| transport |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19q13.33 |
| SNPs
| FTL |
| Gene Sequence
|
>528 bp
ATGAGCTCCCAGATTCGTCAGAATTATTCCACCGACGTGGAGGCAGCCGTCAACAGCCTG
GTCAATTTGTACCTGCAGGCCTCCTACACCTACCTCTCTCTGGGCTTCTATTTCGACCGC
GATGATGTGGCTCTGGAAGGCGTGAGCCACTTCTTCCGCGAACTGGCCGAGGAGAAGCGC
GAGGGCTACGAGCGTCTCCTGAAGATGCAAAACCAGCGTGGCGGCCGCGCTCTCTTCCAG
GACATCAAGAAGCCAGCTGAAGATGAGTGGGGTAAAACCCCAGACGCCATGAAAGCTGCC
ATGGCCCTGGAGAAAAAGCTGAACCAGGCCCTTTTGGATCTTCATGCCCTGGGTTCTGCC
CGCACGGACCCCCATCTCTGTGACTTCCTGGAGACTCACTTCCTAGATGAGGAAGTGAAG
CTTATCAAGAAGATGGGTGACCACCTGACCAACCTCCACAGGCTGGGTGGCCCGGAGGCT
GGGCTGGGCGAGTATCTCTTCGAAAGGCTCACTCTCAAGCACGACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 175 |
| Molecular Weight
| 20019.5 |
| Theoretical pI
| 5.59 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ferritin light chain
MSSQIRQNYSTDVEAAVNSLVNLYLQASYTYLSLGFYFDRDDVALEGVSHFFRELAEEKR
EGYERLLKMQNQRGGRALFQDIKKPAEDEWGKTPDAMKAAMALEKKLNQALLDLHALGSA
RTDPHLCDFLETHFLDEEVKLIKKMGDHLTNLHRLGGPEAGLGEYLFERLTLKHD
|
| External Links |
|---|
| GenBank ID Protein
| 182514 |
| UniProtKB/Swiss-Prot ID
| P02792 |
| UniProtKB/Swiss-Prot Entry Name
| FRIL_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| M11147 |
| GeneCard ID
| FTL |
| GenAtlas ID
| FTL |
| HGNC ID
| HGNC:3999 |
| References |
|---|
| General References
| Not Available |