| Identification |
|---|
| HMDB Protein ID
| CDBP02219 |
| Secondary Accession Numbers
| Not Available |
| Name
| Proton-coupled folate transporter |
| Description
| Not Available |
| Synonyms
|
- G21
- Heme carrier protein 1
- PCFT/HCP1
- Solute carrier family 46 member 1
|
| Gene Name
| SLC46A1 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in transmembrane transport |
| Specific Function
| Has been shown to act both as an intestinal proton- coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| transporter activity |
| Process |
| establishment of localization |
| transport |
| transmembrane transport |
|
| Cellular Location
|
- Cytoplasm
- Multi-pass membrane protein
- Apical cell membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Folate Metabolism |    |  | | Methotrexate Action Pathway |    | Not Available | | Folate malabsorption, hereditary |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 17q11.2 |
| SNPs
| SLC46A1 |
| Gene Sequence
|
>1380 bp
ATGGAGGGGAGCGCGAGCCCCCCGGAAAAGCCCCGCGCCCGCCCTGCGGCTGCCGTGCTG
TGCCGGGGCCCGGTAGAGCCGCTGGTCTTCCTGGCCAACTTTGCCTTGGTCCTGCAGGGC
CCGCTCACCACGCAGTATCTGTGGCACCGCTTCAGCGCCGACCTCGGCTACAATGGCACC
CGCCAAAGGGGGGGCTGCAGCAACCGCAGCGCGGACCCCACCATGCAGGAAGTGGAGACC
CTTACCTCCCACTGGACCCTCTACATGAACGTGGGCGGCTTCCTGGTGGGGCTCTTCTCG
TCCACCCTGCTGGGAGCTTGGAGCGACAGTGTGGGCCGCCGCCCGCTGCTAGTGCTGGCC
TCGCTGGGCCTGCTGCTCCAGGCCCTAGTGTCCGTTTTTGTGGTGCAGCTGCAGCTCCAC
GTCGGCTACTTCGTGCTGGGTCGCATCCTTTGTGCCCTCCTCGGCGACTTCGGTGGCCTT
CTGGCTGCTAGCTTTGCGTCCGTGGCAGATGTCAGCTCCAGTCGCAGCCGCACCTTCCGG
ATGGCCCTGCTAGAAGCCAGCATCGGGGTGGCTGGGATGCTGGCAAGCCTCCTCGGGGGC
CACTGGCTCCGGGCCCAGGGTTATGCCAACCCCTTCTGGCTGGCCTTGGCCTTGCTGATA
GCCATGACTCTCTATGCAGCTTTCTGCTTTGGTGAGACCTTAAAGGAGCCAAAGTCCACC
CGGCTCTTCACGTTCCGTCACCACCGATCCATTGTCCAGCTCTATGTGGCTCCCGCCCCA
GAGAAGTCCAGGAAACATTTAGCCCTCTACTCACTGGCCATCTTCGTGGTGATCACTGTG
CACTTTGGGGCCCAGGACATCTTAACCCTTTATGAACTAAGCACACCCCTCTGCTGGGAC
TCCAAACTAATCGGCTATGGTTCTGCAGCTCAGCATCTCCCCTACCTCACCAGCCTGCTG
GCCCTGAAGCTCCTGCAGTACTGCCTGGCCGATGCCTGGGTAGCTGAGATCGGCCTGGCC
TTCAACATCCTGGGGATGGTGGTCTTTGCCTTTGCCACTATCACGCCTCTCATGTTCACA
GGATATGGGTTGCTTTTCCTGTCATTAGTCATCACACCTGTCATCCGGGCTAAACTCTCC
AAGCTGGTGAGAGAGACAGAGCAGGGTGCTCTCTTTTCTGCTGTGGCCTGTGTGAATAGC
CTGGCCATGCTGACGGCCTCCGGCATCTTCAACTCACTCTACCCAGCCACTCTGAACTTT
ATGAAGGGGTTCCCCTTCCTCCTGGGAGCTGGCCTCCTGCTCATCCCGGCTGTTCTGATT
GGGATGCTGGAAAAGGCTGATCCTCACCTCGAGTTCCAGCAGTTTCCCCAGAGCCCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 459 |
| Molecular Weight
| 49770.0 |
| Theoretical pI
| 8.97 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["87-107", "115-135", "149-169", "183-203", "211-231", "267-287", "303-325", "337-357", "359-379", "390-410", "423-443"]
|
| Protein Sequence
|
>Proton-coupled folate transporter
MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGT
RQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLA
SLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFR
MALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKST
RLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWD
SKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFT
GYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNF
MKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q96NT5 |
| UniProtKB/Swiss-Prot Entry Name
| PCFT_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK054669 |
| GeneCard ID
| SLC46A1 |
| GenAtlas ID
| SLC46A1 |
| HGNC ID
| HGNC:30521 |
| References |
|---|
| General References
| Not Available |