| Identification |
|---|
| HMDB Protein ID
| CDBP00094 |
| Secondary Accession Numbers
| Not Available |
| Name
| Tartrate-resistant acid phosphatase type 5 |
| Description
| Not Available |
| Synonyms
|
- TR-AP
- Tartrate-resistant acid ATPase
- TrATPase
- Type 5 acid phosphatase
|
| Gene Name
| ACP5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity |
| Specific Function
| Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.
|
| GO Classification
|
| Biological Process |
| negative regulation of interleukin-12 production |
| negative regulation of superoxide anion generation |
| negative regulation of inflammatory response |
| riboflavin metabolic process |
| response to lipopolysaccharide |
| negative regulation of interleukin-1 beta production |
| negative regulation of tumor necrosis factor production |
| negative regulation of nitric oxide biosynthetic process |
| defense response to Gram-positive bacterium |
| response to cytokine stimulus |
| bone morphogenesis |
| bone resorption |
| Cellular Component |
| cytosol |
| lysosome |
| integral to membrane |
| Function |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| ferrous iron binding |
| ferric iron binding |
| acid phosphatase activity |
|
| Cellular Location
|
- Lysosome
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Lysosome | Not Available |  | | Osteoclast differentiation | Not Available |  | | Rheumatoid arthritis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19p13.2 |
| SNPs
| ACP5 |
| Gene Sequence
|
>972 bp
ATGGACATGTGGACGGCGCTGCTCATCCTGCAAGCCTTGTTGCTACCCTCCCTGGCTGAT
GGTGCCACCCCTGCCCTGCGCTTTGTAGCCGTGGGTGACTGGGGAGGGGTCCCCAATGCC
CCATTCCACACGGGCCCGGAAATGGCCAATGCCAAGGAGATCGCTCGGACTGTGCAGATC
CTGGGTGCAGACTTCATCCTGTCTCTAGGGGACAATTTTTACTTCACTGGTGTGCAAGAC
ATCAATGACAAGAGGTTCCAGGAGACCTTTGAGGACGTATTCTCTGACCGCTCCCTTCGC
AAAGTGCCCTGGTACGTGCTAGCCGGAAACCATGACCACCTTGGCAATGTCTCTGCCCAG
ATTGCATACTCTAAGATCTCCAAGCGCTGGAACTTCCCCAGCCCTTTCTACCGCCTGCAC
TTCAAGATCCCACAGACCAATGTGTCTGTGGCCATTTTTATGCTGGACACAGTGACACTA
TGTGGCAACTCAGATGACTTCCTCAGCCAGCAGCCTGAGAGGCCCCGACTAACTGCCCGC
ACACAGCTGTCCTGGCTCAAGAAACAGCTGGCGGCGGCCAGGGAGGACTACGTGCTGGTG
GCTGGCCACTACCCCGTGTGGTCCATAGCCGAGCACGGGCCTACCCACTGCCTGGTCAAG
CAGCTACGGCCACTGCTGGCCACATACGGGGTCACTGCCTACCTGTGCGGCCACGATCAC
AATCTGCAGTACCTGCAAGATGAGAATGGCGTGGGCTACGTGCTGAGTGGGGCTGGGAAT
TTCATGGACCCCTCAAAGCGGCACCAGCGCAAGGTCCCCAACGGCTATCTGCGCTTCCAC
TATGGGACTGAAGACTCACTGGGTGGCTTTGCCTATGTGGAGATCAGCTCCAAAGAGATG
ACTGTCACTTACATCGAGGCCTCGGGCAAGTCCCTCTTTAAGACCAGGCTGCCGAGGCGA
GCCAGGCCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 325 |
| Molecular Weight
| 36598.47 |
| Theoretical pI
| 8.701 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Tartrate-resistant acid phosphatase type 5
MDMWTALLILQALLLPSLADGATPALRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQI
LGADFILSLGDNFYFTGVQDINDKRFQETFEDVFSDRSLRKVPWYVLAGNHDHLGNVSAQ
IAYSKISKRWNFPSPFYRLHFKIPQTNVSVAIFMLDTVTLCGNSDDFLSQQPERPRDVKL
ARTQLSWLKKQLAAAREDYVLVAGHYPVWSIAEHGPTHCLVKQLRPLLATYGVTAYLCGH
DHNLQYLQDENGVGYVLSGAGNFMDPSKRHQRKVPNGYLRFHYGTEDSLGGFAYVEISSK
EMTVTYIEASGKSLFKTRLPRRARP
|
| External Links |
|---|
| GenBank ID Protein
| 178006 |
| UniProtKB/Swiss-Prot ID
| P13686 |
| UniProtKB/Swiss-Prot Entry Name
| PPA5_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| J04430 |
| GeneCard ID
| ACP5 |
| GenAtlas ID
| ACP5 |
| HGNC ID
| HGNC:124 |
| References |
|---|
| General References
| Not Available |