| Identification |
|---|
| HMDB Protein ID
| CDBP00188 |
| Secondary Accession Numbers
| Not Available |
| Name
| Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- Ip
- Iron-sulfur subunit of complex II
|
| Gene Name
| SDHB |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in electron carrier activity |
| Specific Function
| Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| tricarboxylic acid cycle |
| succinate metabolic process |
| respiratory electron transport chain |
| Cellular Component |
| mitochondrial respiratory chain complex II |
| Function |
| oxidoreductase activity |
| binding |
| catalytic activity |
| electron carrier activity |
| metal cluster binding |
| iron-sulfur cluster binding |
| Molecular Function |
| electron carrier activity |
| metal ion binding |
| 2 iron, 2 sulfur cluster binding |
| 4 iron, 4 sulfur cluster binding |
| 3 iron, 4 sulfur cluster binding |
| succinate dehydrogenase (ubiquinone) activity |
| ubiquinone binding |
| Process |
| metabolic process |
| cellular metabolic process |
| oxidation reduction |
| cofactor metabolic process |
| coenzyme metabolic process |
| acetyl-coa metabolic process |
| acetyl-coa catabolic process |
| tricarboxylic acid cycle |
|
| Cellular Location
|
- Peripheral membrane protein
- Mitochondrion inner membrane
- Matrix side
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | tricarboxylic acid cycle | Not Available | Not Available | | Citrate cycle (TCA cycle) | Not Available |  | | Oxidative phosphorylation | Not Available |  | | Alzheimer's disease | Not Available |  | | Parkinson's disease | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p36.1-p35 |
| SNPs
| SDHB |
| Gene Sequence
|
>843 bp
ATGGCGGCGGTGGTCGCACTCTCCTTGAGGCGCCGGTTGCCGGCCACAACCCTTGGCGGA
GCCTGCCTGCAGGCCTCCCGAGGAGCCCAGACAGCTGCAGCCACAGCTCCCCGTATCAAG
AAATTTGCCATCTATCGATGGGACCCAGACAAGGCTGGAGACAAACCTCATATGCAGACT
TATGAAGTTGACCTTAATAAATGTGGCCCCATGGTATTGGATGCTTTAATCAAGATTAAG
AATGAAGTTGACTCTACTTTGACCTTCCGAAGATCATGCAGAGAAGGCATCTGTGGCTCT
TGTGCAATGAACATCAATGGAGGCAACACTCTAGCTTGCACCCGAAGGATTGACACCAAC
CTCAATAAGGTCTCAAAAATCTACCCTCTTCCACACATGTATGTGATAAAGGATCTTGTT
CCCGATTTGAGCAACTTCTATGCACAGTACAAATCCATTGAGCCTTATTTGAAGAAGAAG
GATGAATCTCAGGAAGGCAAGCAGCAGTATCTGCAGTCCATAGAAGAGCGTGAGAAACTG
GACGGGCTCTACGAGTGCATTCTCTGTGCCTGCTGTAGCACCAGCTGCCCCAGCTACTGG
TGGAACGGAGACAAATATCTGGGGCCTGCAGTTCTTATGCAGGCCTATCGCTGGATGATT
GACTCCAGAGATGACTTCACAGAGGAGCGCCTGGCCAAGCTGCAGGACCCATTCTCTCTA
TACCGCTGCCACACCATCATGAACTGCACAAGGACCTGTCCTAAGGGTCTGAATCCAGGG
AAAGCTATTGCAGAGATCAAGAAAATGATGGCAACCTATAAGGAGAAGAAAGCTTCAGTT
TAA
|
| Protein Properties |
|---|
| Number of Residues
| 280 |
| Molecular Weight
| 31629.365 |
| Theoretical pI
| 8.76 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQT
YEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTN
LNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKL
DGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSL
YRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV
|
| External Links |
|---|
| GenBank ID Protein
| 189065269 |
| UniProtKB/Swiss-Prot ID
| P21912 |
| UniProtKB/Swiss-Prot Entry Name
| DHSB_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK312056 |
| GeneCard ID
| SDHB |
| GenAtlas ID
| SDHB |
| HGNC ID
| HGNC:10681 |
| References |
|---|
| General References
| Not Available |