Cannabis Compound Database: Showing Protein Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (CDBP01666)

Identification Biological properties Gene properties Protein properties External links References XML Show 4 compounds

Identification

HMDB Protein ID

CDBP01666

Secondary Accession Numbers

Not Available

Name

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

Description

Not Available

Synonyms

PP-1G
Protein phosphatase 1C catalytic subunit

Gene Name

PPP1CC

Protein Type

Enzyme

Biological Properties

General Function

Involved in hydrolase activity

Specific Function

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

GO Classification

Biological Process
negative regulation of transforming growth factor beta receptor signaling pathway
transforming growth factor beta receptor signaling pathway
regulation of nucleocytoplasmic transport
protein dephosphorylation
small molecule metabolic process
cell division
glycogen metabolic process
mitotic prometaphase
triglyceride catabolic process
Cellular Component
cytosol
mitochondrion
nucleolus
nuclear speck
cleavage furrow
condensed chromosome kinetochore
mitochondrial outer membrane
PTW/PP1 phosphatase complex
midbody
MLL5-L complex
Function
catalytic activity
hydrolase activity
Molecular Function
protein serine/threonine phosphatase activity
metal ion binding

Cellular Location

Nucleus
Nucleus
Nucleus
Cytoplasm
nucleolus
Nucleus speckle
Chromosome
centromere
nucleoplasm
kinetochore
Cleavage furrow
Midbody

Pathways

Name	SMPDB/Pathwhiz	KEGG
mRNA surveillance pathway	Not Available
Oocyte meiosis	Not Available
Vascular smooth muscle contraction	Not Available
Hippo signaling pathway	Not Available
Focal adhesion	Not Available

Gene Properties

Chromosome Location

Locus

12q24.1-q24.2

SNPs

PPP1CC

Gene Sequence

>972 bp
ATGGCGGATTTAGATAAACTCAACATCGACAGCATTATCCAACGGCTGCTGGAAGTGAGA
GGGTCCAAGCCTGGTAAGAATGTCCAGCTTCAGGAGAATGAAATCAGAGGACTGTGCTTA
AAGTCTCGTGAAATCTTTCTCAGTCAGCCTATCCTACTAGAACTTGAAGCACCACTCAAA
ATATGTGGTGACATCCATGGACAATACTATGATTTGCTGCGACTTTTTGAGTACGGTGGT
TTCCCACCAGAAAGCAACTACCTGTTTCTTGGGGACTATGTGGACAGGGGAAAGCAGTCA
TTGGAGACGATCTGCCTCTTACTGGCCTACAAAATAAAATATCCTGAGAATTTTTTTCTT
CTCAGAGGGAACCATGAATGTGCCAGCATCAACAGAATTTATGGATTTTATGATGAATGT
AAAAGAAGATACAACATTAAACTATGGAAAACTTTCACAGACTGTTTTAACTGTTTACCG
ATAGCAGCCATCGTGGATGAGAAGATATTCTGCTGTCATGGAGGTTTATCACCAGATCTT
CAATCTATGGAGCAGATTCGGCGAATTATGCGACCAACTGATGTACCAGATCAAGGTCTT
CTTTGTGATCTTTTGTGGTCTGACCCCGATAAAGATGTCTTAGGCTGGGGTGAAAATGAC
AGAGGAGTGTCCTTCACATTTGGTGCAGAAGTGGTTGCAAAATTTCTCCATAAGCATGAT
TTGGATCTTATATGTAGAGCCCATCAGGTGGTTGAAGATGGATATGAATTTTTTGCAAAG
AGGCAGTTGGTCACTCTGTTTTCTGCGCCCAATTATTGCGGAGAGTTTGACAATGCAGGT
GCCATGATGAGTGTGGATGAAACACTAATGTGTTCTTTTCAGATTTTAAAGCCTGCAGAG
AAAAAGAAGCCAAATGCCACGAGACCTGTAACGCCTCCAAGGGGTATGATCACAAAGCAA
GCAAAGAAATAG

Protein Properties

Number of Residues

323

Molecular Weight

38517.92

Theoretical pI

6.121

Pfam Domain Function

Metallophos (PF00149 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
MADLDKLNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLK
ICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFL
LRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDL
QSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHD
LDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAE
KKKPNATRPVTPPRGMITKQAKK

External Links

GenBank ID Protein

402778

UniProtKB/Swiss-Prot ID

P36873

UniProtKB/Swiss-Prot Entry Name

PP1G_HUMAN

PDB IDs