| Identification |
|---|
| HMDB Protein ID
| CDBP03897 |
| Secondary Accession Numbers
| Not Available |
| Name
| Serine/threonine-protein phosphatase 5 |
| Description
| Not Available |
| Synonyms
|
- PP-T
- PP5
- PPT
- Protein phosphatase T
|
| Gene Name
| PPP5C |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity |
| Specific Function
| May play a role in the regulation of RNA biogenesis and/or mitosis. In vitro, dephosphorylates serine residues of skeletal muscle phosphorylase and histone H1.
|
| GO Classification
|
| Biological Process |
| positive regulation of I-kappaB kinase/NF-kappaB cascade |
| transcription, DNA-dependent |
| response to morphine |
| mitosis |
| protein dephosphorylation |
| Cellular Component |
| cytosol |
| Golgi apparatus |
| nucleus |
| neuronal cell body |
| neuron projection |
| Component |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| nucleus |
| cell part |
| intracellular part |
| cytoplasm |
| organelle |
| Function |
| phosphoprotein phosphatase activity |
| ion binding |
| cation binding |
| metal ion binding |
| hydrolase activity, acting on ester bonds |
| binding |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| protein serine/threonine phosphatase activity |
| Molecular Function |
| signal transducer activity |
| protein serine/threonine phosphatase activity |
| metal ion binding |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| dephosphorylation |
| protein amino acid dephosphorylation |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | MAPK signaling pathway | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19q13.3 |
| SNPs
| PPP5C |
| Gene Sequence
|
>1500 bp
ATGGCGATGGCGGAGGGCGAGAGGACTGAGTGTGCTGAGCCCCCCCGGGACGAACCCCCG
GCTGATGGAGCTCTGAAGCGGGCAGAGGAGCTCAAGACTCAGGCCAATGACTACTTCAAA
GCCAAGGACTACGAGAACGCCATCAAGTTCTACAGCCAGGCCATCGAGCTGAACCCCAGC
AATGCCATCTACTATGGCAACCGCAGCCTGGCCTACCTGCGCACTGAGTGCTATGGCTAC
GCGCTGGGAGACGCCACGCGGGCCATTGAGCTGGACAAGAAGTACATCAAGGGTTATTAC
CGCCGGGCTGCCAGCAACATGGCACTGGGCAAGTTCCGGGCCGCGCTGCGAGACTACGAG
ACGGTGGTCAAGGTGAAGCCCCATGACAAGGATGCCAAAATGAAATACCAGGAGTGCAAC
AAGATCGTGAAGCAGAAGGCCTTTGAGCGGGCCATCGCGGGCGACGAGCACAAGCGCTCC
GTGGTGGACTCGCTGGACATCGAGAGCATGACCATTGAGGATGAGTACAGCGGACCCAAG
CTTGAAGACGGCAAAGTGACAATCAGTTTCATGAAGGAGCTCATGCAGTGGTACAAGGAC
CAGAAGAAACTGCACCGGAAATGTGCCTACCAGATTCTGGTACAGGTCAAAGAGGTCCTC
TCCAAGCTGAGCACGCTCGTGGAAACCACACTCAAAGAGACAGAGAAGATTACAGTATGT
GGGGACACCCATGGCCAGTTCTATGACCTCCTCAACATATTCGAGCTCAACGGTTTACCC
TCGGAGACCAACCCCTATATATTTAATGGTGACTTTGTGGACCGAGGCTCCTTCTCTGTA
GAAGTGATCCTCACCCTTTTCGGCTTCAAGCTCCTGTACCCAGATCACTTTCACCTCCTT
CGAGGCAACCACGAGACAGACAACATGAACCAGATCTACGGTTTCGAGGGTGAGGTGAAG
GCCAAGTACACAGCCCAGATGTACGAGCTCTTTAGCGAGGTGTTCGAGTGGCTCCCGTTG
GCCCAGTGCATCAACGGCAAAGTGCTGATCATGCACGGAGGCCTGTTCAGTGAAGACGGT
GTCACCCTGGATGACATCCGGAAAATTGAGCGGAATCGACAACCCCCAGATTCAGGGCCC
ATGTGTGACCTGCTCTGGTCAGATCCACAGCCACAGAACGGGCGCTCGATCAGCAAGCGG
GGCGTGAGCTGTCAGTTTGGGCCTGACGTCACCAAGGCCTTCTTGGAAGAGAACAACCTG
GACTATATCATCCGCAGCCACGAAGTCAAGGCCGAGGGCTACGAGGTGGCTCACGGAGGC
CGCTGTGTCACCGTCTTCTCTGCCCCCAACTACTGCGACCAGATGGGGAACAAAGCCTCC
TACATCCACCTCCAGGGCTCTGACCTACGGCCTCAGTTCCACCAGTTCACAGCAGTGCCT
CATCCCAACGTCAAGCCCATGGCCTATGCCAACACGCTGCTGCAGCTAGGAATGATGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 499 |
| Molecular Weight
| 56878.22 |
| Theoretical pI
| 6.274 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Serine/threonine-protein phosphatase 5
MAMAEGERTECAEPPRDEPPADGALKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPS
NAIYYGNRSLAYLRTECYGYALGDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYE
TVVKVKPHDKDAKMKYQECNKIVKQKAFERAIAGDEHKRSVVDSLDIESMTIEDEYSGPK
LEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVC
GDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLL
RGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDG
VTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNL
DYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVP
HPNVKPMAYANTLLQLGMM
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P53041 |
| UniProtKB/Swiss-Prot Entry Name
| PPP5_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| BT007275 |
| GeneCard ID
| PPP5C |
| GenAtlas ID
| PPP5C |
| HGNC ID
| HGNC:9322 |
| References |
|---|
| General References
| Not Available |