| Identification |
|---|
| HMDB Protein ID
| CDBP03898 |
| Secondary Accession Numbers
| Not Available |
| Name
| Serine/threonine-protein phosphatase 6 catalytic subunit |
| Description
| Not Available |
| Synonyms
|
- PP6C
|
| Gene Name
| PPP6C |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity |
| Specific Function
| Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7.
|
| GO Classification
|
| Biological Process |
| G1/S transition of mitotic cell cycle |
| protein dephosphorylation |
| Cellular Component |
| cytosol |
| Function |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| protein serine/threonine phosphatase activity |
| metal ion binding |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| 9q33.3 |
| SNPs
| PPP6C |
| Gene Sequence
|
>918 bp
ATGGCGCCGCTAGACCTGGACAAGTATGTGGAAATAGCGCGGCTGTGCAAGTACCTGCCA
GAGAACGACCTGAAGCGGCTATGTGACTACGTTTGTGACCTCCTCTTAGAAGAGTCAAAT
GTTCAGCCAGTATCAACACCAGTAACAGTGTGTGGAGATATCCATGGACAGTTTTATGAC
CTTTGTGAACTGTTCAGAACTGGAGGTCAGGTTCCTGACACAAACTACATATTTATGGGT
GATTTTGTAGACAGAGGTTACTATAGTTTGGAGACCTTCACTTACCTTCTTGCATTAAAG
GCTAAATGGCCTGATCGTATTACACTTTTGCGAGGAAATCATGAGAGTAGACAGATAACA
CAGGTCTATGGATTTTATGATGAGTGCCAAACCAAATATGGAAATGCTAATGCCTGGAGA
TACTGTACCAAAGTTTTTGACATGCTCACAGTAGCAGCTTTAATAGATGAGCAGATTTTG
TGTGTCCATGGTGGTTTATCTCCTGATATCAAAACACTGGATCAAATTCGAACCATCGAA
CGGAATCAGGAAATTCCTCATAAAGGAGCATTTTGTGATCTGGTTTGGTCAGATCCTGAA
GATGTGGATACCTGGGCTATCAGTCCCCGAGGAGCAGGTTGGCTTTTTGGAGCAAAGGTC
ACAAATGAGTTTGTTCATATCAACAACTTAAAACTCATCTGCAGAGCACATCAACTAGTG
CACGAAGGCTATAAATTTATGTTTGATGAGAAGCTGGTGACAGTATGGTCTGCTCCTAAT
TACTGCTATCGTTGTGGAAATATTGCTTCGATCATGGTCTTCAAAGATGTAAATACAAGA
GAACCAAAGTTATTCCGGGCAGTTCCAGATTCAGAACGTGTTATTCCTCCCAGAACGACA
ACGCCATATTTCCTTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 305 |
| Molecular Weight
| 38946.415 |
| Theoretical pI
| 6.179 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Serine/threonine-protein phosphatase 6 catalytic subunit
MAPLDLDKYVEIARLCKYLPENDLKRLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYD
LCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQIT
QVYGFYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIE
RNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLV
HEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDSERVIPPRTT
TPYFL
|
| External Links |
|---|
| GenBank ID Protein
| 4506029 |
| UniProtKB/Swiss-Prot ID
| O00743 |
| UniProtKB/Swiss-Prot Entry Name
| PPP6_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_002721.4 |
| GeneCard ID
| PPP6C |
| GenAtlas ID
| PPP6C |
| HGNC ID
| HGNC:9323 |
| References |
|---|
| General References
| Not Available |