| Identification |
|---|
| HMDB Protein ID
| CDBP00993 |
| Secondary Accession Numbers
| Not Available |
| Name
| Thiosulfate sulfurtransferase |
| Description
| Not Available |
| Synonyms
|
- Rhodanese
|
| Gene Name
| TST |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in thiosulfate sulfurtransferase activity |
| Specific Function
| Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA.
|
| GO Classification
|
| Biological Process |
| sulfur amino acid catabolic process |
| sulfide oxidation, using sulfide:quinone oxidoreductase |
| rRNA import into mitochondrion |
| cyanate catabolic process |
| Cellular Component |
| mitochondrial matrix |
| plasma membrane |
| mitochondrial inner membrane |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring sulfur-containing groups |
| sulfurtransferase activity |
| thiosulfate sulfurtransferase activity |
| Molecular Function |
| thiosulfate sulfurtransferase activity |
| 5S rRNA binding |
| Process |
| establishment of localization |
| transport |
| anion transport |
| inorganic anion transport |
| sulfate transport |
| ion transport |
|
| Cellular Location
|
- Mitochondrion matrix
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Cysteine and methionine metabolism | Not Available |  | | Sulfur relay system | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| 22q13.1 |
| SNPs
| TST |
| Gene Sequence
|
>894 bp
ATGGTTCATCAGGTGCTCTACCGGGCGCTGGTCTCCACCAAGTGGCTGGCGGAGTCCATC
AGGACTGGCAAGCTGGGGCCCGGCCTGCGGGTGCTGGACGCGTCCTGGTACTCACCAGGC
ACCCGAGAGGCCCGCAAGGAGTACCTCGAGCGCCACGTACCCGGCGCCTCTTTCTTTGAC
ATAGAAGAGTGCCGGGACACGGCGTCGCCCTACGAGATGATGCTGCCCAGCGAGGCTGGC
TTCGCCGAGTATGTGGGCCGCCTGGGCATCAGCAACCACACGCACGTGGTGGTGTATGAT
GGTGAACACCTGGGCAGCTTCTATGCTCCCCGGGTCTGGTGGATGTTCCGTGTGTTTGGC
CACCGCACCGTATCAGTGCTCAATGGTGGCTTCCGGAACTGGCTGAAGGAGGGCCACCCG
GTGACATCCGAGCCCTCACGCCCAGAACCGGCCGTCTTCAAAGCCACACTGGACCGCTCC
CTGCTCAAGACCTACGAGCAGGTGCTGGAGAACCTTGAATCTAAGAGGTTCCAGCTGGTG
GATTCAAGGTCTCAAGGGCGGTTCCTGGGCACCGAGCCGGAGCCGGATGCAGTAGGACTG
GACTCGGGCCATATCCGTGGTGCCGTCAACATGCCTTTCATGGACTTCCTGACTGAGGAT
GGCTTCGAGAAGGGCCCAGAAGAGCTCCGTGCTCTGTTCCAGACCAAGAAGGTGGATCTC
TCGCAGCCTCTCATTGCCACGTGCCGCAAGGGAGTCACCGCCTGCCACGTGGCCTTGGCT
GCCTACCTCTGCGGCAAGCCTGATGTGGCCGTGTACGATGGCTCCTGGTCCGAGTGGTTT
CGCCGGGCCCCCCCAGAGAGCCGTGTGTCCCAGGGAAAGTCTGAGAAGGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 297 |
| Molecular Weight
| 33428.69 |
| Theoretical pI
| 7.252 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Thiosulfate sulfurtransferase
MVHQVLYRALVSTKWLAESIRTGKLGPGLRVLDASWYSPGTREARKEYLERHVPGASFFD
IEECRDTASPYEMMLPSEAGFAEYVGRLGISNHTHVVVYDGEHLGSFYAPRVWWMFRVFG
HRTVSVLNGGFRNWLKEGHPVTSEPSRPEPAVFKATLDRSLLKTYEQVLENLESKRFQLV
DSRSQGRFLGTEPEPDAVGLDSGHIRGAVNMPFMDFLTEDGFEKGPEELRALFQTKKVDL
SQPLIATCRKGVTACHVALAAYLCGKPDVAVYDGSWSEWFRRAPPESRVSQGKSEKA
|
| External Links |
|---|
| GenBank ID Protein
| 193787227 |
| UniProtKB/Swiss-Prot ID
| Q16762 |
| UniProtKB/Swiss-Prot Entry Name
| THTR_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK091874 |
| GeneCard ID
| TST |
| GenAtlas ID
| TST |
| HGNC ID
| HGNC:12388 |
| References |
|---|
| General References
| Not Available |