Showing Protein Natural resistance-associated macrophage protein 1 (CDBP03890)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 compounds
Identification
HMDB Protein ID CDBP03890
Secondary Accession Numbers Not Available
Name Natural resistance-associated macrophage protein 1
Description Not Available
Synonyms
  1. NRAMP 1
Gene Name SLC11A1
Protein Type Transporter
Biological Properties
General Function Involved in transporter activity
Specific Function Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes
GO Classification
Component
membrane
cell part
Function
transporter activity
Process
establishment of localization
transport
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein (Probable)
Pathways
Gene Properties
Chromosome Location Chromosome:2
Locus 2q35
SNPs SLC11A1
Gene Sequence 
>1653 bp
ATGACAGGTGACAAGGGTCCCCAAAGGCTAAGCGGGTCCAGCTATGGTTCCATCTCCAGC
CCGACCAGCCCGACCAGCCCAGGGCCACAGCAAGCACCTCCCAGAGAGACCTACCTGAGT
GAGAAGATCCCCATCCCAGACACAAAACCGGGCACCTTCAGCCTGCGGAAGCTATGGGCC
TTCACGGGGCCTGGCTTCCTCATGAGCATTGCTTTCCTGGACCCAGGAAACATCGAGTCA
GATCTTCAGGCTGGCGCCGTGGCGGGATTCAAACTTCTCTGGGTGCTGCTCTGGGCCACC
GTGTTGGGCTTGCTCTGCCAGCGACTGGCTGCACGTCTGGGCGTGGTGACAGGCAAGGAC
TTGGGCGAGGTCTGCCATCTCTACTACCCTAAGGTGCCCCGCACCGTCCTCTGGCTGACC
ATCGAGCTAGCCATTGTGGGCTCCGACATGCAGGAAGTCATCGGCACGGCCATTGCATTC
AATCTGCTCTCAGCTGGACGAATCCCACTCTGGGGTGGCGTCCTCATCACCATCGTGGAC
ACCTTCTTCTTCCTCTTCCTCGATAACTACGGGCTGCGGAAGCTGGAAGCTTTTTTTGGA
CTCCTTATAACCATTATGGCCTTGACCTTTGGCTATGAGTATGTGGTGGCGCGTCCTGAG
CAGGGAGCGCTTCTTCGGGGCCTGTTCCTGCCCTCGTGCCCGGGCTGCGGCCACCCCGAG
CTGCTGCAGGCGGTGGGCATTGTTGGCGCCATCATCATGCCCCACAACATCTACCTGCAC
TCGGCCCTGGTCAAGTCTCGAGAGATAGACCGGGCCCGCCGAGCGGACATCAGAGAAGCC
AACATGTACTTCCTGATTGAGGCCACCATCGCCCTGTCCGTCTCCTTTATCATCAACCTC
TTTGTCATGGCTGTCTTTGGGCAGGCCTTCTACCAGAAAACCAACCAGGCTGCGTTCAAC
ATCTGTGCCAACAGCAGCCTCCACGACTACGCCAAGATCTTCCCCATGAACAACGCCACC
GTGGCCGTGGACATTTACCAGGGGGGCGTGATCCTGGGCTGCCTGTTCGGCCCCGCGGCC
CTCTACATCTGGGCCATAGGTCTCCTGGCGGCTGGGCAGAGCTCCACCATGACGGGCACC
TACGCGGGACAGTTCGTGATGGAGGGCTTCCTGAGGCTGCGGTGGTCACGCTTCGCCCGT
GTCCTCCTCACCCGCTCCTGCGCCATCCTGCCCACCGTGCTCGTGGCTGTCTTCCGGGAC
CTGAGGGACTTGTCGGGCCTCAATGATCTGCTCAACGTGCTGCAGAGCCTGCTGCTCCCG
TTCGCCGTGCTGCCCATCCTCACGTTCACCAGCATGCCCACCCTCATGCAGGAGTTTGCC
AATGGCCTGCTGAACAAGGTCGTCACCTCTTCCATCATGGTGCTAGTCTGCGCCATCAAC
CTCTACTTCGTGGTCAGCTATCTGCCCAGCCTGCCCCACCCTGCCTACTTCGGCCTTGCA
GCCTTGCTGGCCGCAGCCTACCTGGGCCTCAGCACCTACCTGGTCTGGACCTGTTGCCTT
GCCCACGGAGCCACCTTTCTGGCCCACAGCTCCCACCACCACTTCCTGTATGGGCTCCTT
GAAGAGGACCAGAAAGGGGAGACCTCTGGCTAG
Protein Properties
Number of Residues 550
Molecular Weight 59871.6
Theoretical pI 7.72
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["59-76", "86-105", "143-163", "168-187", "197-217", "241-259", "288-307", "350-369", "401-418", "430-450", "467-488", "497-516"]
Protein Sequence 
>Natural resistance-associated macrophage protein 1
MTGDKGPQRLSGSSYGSISSPTSPTSPGPQQAPPRETYLSEKIPIPDTKPGTFSLRKLWA
FTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKD
LGEVCHLYYPKVPRTVLWLTIELAIVGSDMQEVIGTAIAFNLLSAGRIPLWGGVLITIVD
TFFFLFLDNYGLRKLEAFFGLLITIMALTFGYEYVVARPEQGALLRGLFLPSCPGCGHPE
LLQAVGIVGAIIMPHNIYLHSALVKSREIDRARRADIREANMYFLIEATIALSVSFIINL
FVMAVFGQAFYQKTNQAAFNICANSSLHDYAKIFPMNNATVAVDIYQGGVILGCLFGPAA
LYIWAIGLLAAGQSSTMTGTYAGQFVMEGFLRLRWSRFARVLLTRSCAILPTVLVAVFRD
LRDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPTLMQEFANGLLNKVVTSSIMVLVCAIN
LYFVVSYLPSLPHPAYFGLAALLAAAYLGLSTYLVWTCCLAHGATFLAHSSHHHFLYGLL
EEDQKGETSG
GenBank ID Protein 10257411
UniProtKB/Swiss-Prot ID P49279
UniProtKB/Swiss-Prot Entry Name NRAM1_HUMAN
PDB IDs Not Available
GenBank Gene ID AF229163
GeneCard ID SLC11A1
GenAtlas ID SLC11A1
HGNC ID HGNC:10907
References
General References Not Available