| Identification |
|---|
| HMDB Protein ID
| CDBP00264 |
| Secondary Accession Numbers
| Not Available |
| Name
| Phytanoyl-CoA dioxygenase, peroxisomal |
| Description
| Not Available |
| Synonyms
|
- PhyH
- Phytanic acid oxidase
- Phytanoyl-CoA alpha-hydroxylase
|
| Gene Name
| PHYH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in electron carrier activity |
| Specific Function
| Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA.
|
| GO Classification
|
| Biological Process |
| methyl-branched fatty acid metabolic process |
| isoprenoid metabolic process |
| fatty acid alpha-oxidation |
| Cellular Component |
| mitochondrion |
| peroxisomal matrix |
| Molecular Function |
| electron carrier activity |
| metal ion binding |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| cofactor binding |
| L-ascorbic acid binding |
| phytanoyl-CoA dioxygenase activity |
|
| Cellular Location
|
- Peroxisome
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Oxidation of Branched Chain Fatty Acids |    | Not Available | | Phytanic Acid Peroxisomal Oxidation |    | Not Available | | Peroxisome | Not Available |  | | Refsum Disease |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| 10p13 |
| SNPs
| PHYH |
| Gene Sequence
|
>1017 bp
ATGGAGCAGCTTCGCGCCGCCGCCCGTCTGCAGATTGTTCTGGGCCACCTCGGCCGCCCC
TCGGCCGGGGCTGTCGTAGCTCATCCCACTTCAGGGACTATTTCCTCTGCCAGTTTCCAT
CCTCAACAATTCCAGTATACTCTGGATAATAATGTTCTAACCCTGGAACAGAGAAAATTT
TATGAAGAAAATGGGTTTCTAGTAATCAAAAATCTTGTACCTGATGCCGATATTCAACGC
TTTCGGAATGAGTTTGAAAAAATCTGCAGAAAGGAGGTGAAACCATTAGGATTAACAGTA
ATGAGAGATGTGACCATTTCGAAATCCGAATATGCTCCAAGTGAGAAGATGATCACGAAG
GTCCAGGATTTCCAGGAAGATAAGGAGCTCTTCAGATACTGCACTCTCCCCGAGATTCTG
AAATATGTGGAGTGCTTCACTGGACCTAATATTATGGCCATGCACACAATGTTGATAAAC
AAACCTCCAGATTCTGGCAAGAAGACGTCCCGTCACCCCCTGCACCAGGACCTGCACTAT
TTCCCCTTCAGGCCCAGCGATCTCATCGTTTGCGCCTGGACGGCGATGGAGCACATCAGC
CGGAACAACGGCTGTCTGGTTGTGCTCCCAGGCACGCACAAGGGCTCCCTGAAGCCCCAC
GATTACCCCAAGTGGGAGGGGGGAGTTAACAAAATGTTCCACGGGATCCAGGACTACGAG
GAAAACAAGGCCCGGGTGCACCTGGTGATGGAGAAGGGCGACACTGTTTTCTTCCATCCT
TTGCTCATCCACGGATCTGGTCAGAATAAAACCCAGGGATTCCGGAAGGCAATTTCCTGC
CATTTCGCCAGTGCCGATTGCCACTACATTGACGTGAAGGGCACCAGTCAAGAAAACATC
GAGAAGGAAGTTGTAGGAATAGCACATAAATTCTTTGGAGCTGAAAATAGCGTGAACTTG
AAGGATATTTGGATGTTTCGAGCTCGACTTGTGAAAGGAGAAAGAACCAATCTTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 338 |
| Molecular Weight
| 38538.065 |
| Theoretical pI
| 8.477 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Phytanoyl-CoA dioxygenase, peroxisomal
MEQLRAAARLQIVLGHLGRPSAGAVVAHPTSGTISSASFHPQQFQYTLDNNVLTLEQRKF
YEENGFLVIKNLVPDADIQRFRNEFEKICRKEVKPLGLTVMRDVTISKSEYAPSEKMITK
VQDFQEDKELFRYCTLPEILKYVECFTGPNIMAMHTMLINKPPDSGKKTSRHPLHQDLHY
FPFRPSDLIVCAWTAMEHISRNNGCLVVLPGTHKGSLKPHDYPKWEGGVNKMFHGIQDYE
ENKARVHLVMEKGDTVFFHPLLIHGSGQNKTQGFRKAISCHFASADCHYIDVKGTSQENI
EKEVVGIAHKFFGAENSVNLKDIWMFRARLVKGERTNL
|
| External Links |
|---|
| GenBank ID Protein
| 83281447 |
| UniProtKB/Swiss-Prot ID
| O14832 |
| UniProtKB/Swiss-Prot Entry Name
| PAHX_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF023462 |
| GeneCard ID
| PHYH |
| GenAtlas ID
| PHYH |
| HGNC ID
| HGNC:8940 |
| References |
|---|
| General References
| Not Available |