Showing Protein Transcription factor NF-E2 45 kDa subunit (CDBP01975)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 compounds
Identification
HMDB Protein ID CDBP01975
Secondary Accession Numbers Not Available
Name Transcription factor NF-E2 45 kDa subunit
Description Not Available
Synonyms
  1. Leucine zipper protein NF-E2
  2. Nuclear factor, erythroid-derived 2 45 kDa subunit
  3. p45 NF-E2
Gene Name NFE2
Protein Type Transcription Factor
Biological Properties
General Function Involved in sequence-specific DNA binding transcription factor activity
Specific Function Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron
GO Classification
Function
protein dimerization activity
sequence-specific dna binding
sequence-specific dna binding transcription factor activity
binding
protein binding
nucleic acid binding
dna binding
Process
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
regulation of gene expression
regulation of transcription
regulation of transcription, dna-dependent
Cellular Location
  1. Nucleus
  2. Cytoplasm
  3. PML body
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 12q13
SNPs NFE2
Gene Sequence 
>1122 bp
ATGTCCCCGTGTCCTCCCCAGCAGAGCAGGAACAGGGTGATACAGCTGTCCACTTCAGAG
CTAGGAGAGATGGAACTGACTTGGCAGGAGATCATGTCCATCACCGAGCTGCAGGGTCTG
AATGCTCCAAGTGAGCCATCATTTGAGCCCCAAGCCCCAGCTCCATACCTTGGACCTCCA
CCACCCACAACTTACTGCCCCTGCTCAATCCACCCAGATTCTGGCTTCCCACTTCCTCCA
CCACCTTATGAGCTCCCAGCATCCACATCCCATGTCCCAGATCCCCCATACTCCTATGGC
AACATGGCCATACCAGTCTCCAAGCCACTGAGCCTCTCAGGCCTGCTCAGTGAGCCGCTC
CAAGACCCCTTAGCCCTCCTGGACATTGGGCTGCCAGCAGGGCCACCTAAGCCCCAAGAA
GACCCAGAATCCGACTCAGGATTATCCCTCAACTATAGCGATGCTGAATCTCTTGAGCTG
GAGGGGACAGAGGCTGGTCGGCGGCGCAGCGAATATGTAGAGATGTACCCAGTGGAGTAC
CCCTACTCACTCATGCCCAACTCCTTGGCCCACTCCAACTATACCTTGCCAGCTGCTGAG
ACCCCCTTGGCCTTAGAGCCCTCCTCAGGCCCTGTGCGGGCTAAGCCCACTGCACGGGGG
GAGGCAGGGAGTCGGGATGAACGTCGGGCCTTGGCCATGAAGATTCCTTTTCCTACGGAC
AAGATTGTCAACTTGCCGGTAGATGACTTTAATGAGCTATTGGCAAGGTACCCGCTGACA
GAGAGCCAGCTAGCGCTAGTCCGGGACATCCGACGACGGGGCAAAAACAAGGTGGCAGCC
CAGAACTGCCGCAAGAGGAAGCTGGAAACCATTGTGCAGCTGGAGCGGGAGCTGGAGCGG
CTGACCAATGAACGGGAGCGGCTTCTCAGGGCCCGCGGGGAGGCAGACCGGACCCTGGAG
GTCATGCGCCAACAGCTGACAGAGCTGTACCGTGACATTTTCCAGCACCTTCGGGATGAA
TCAGGCAACAGCTACTCTCCTGAAGAGTACGCGCTGCAACAGGCTGCCGATGGGACCATC
TTCCTTGTGCCCCGGGGGACCAAGATGGAGGCCACAGACTGA
Protein Properties
Number of Residues 373
Molecular Weight 41472.2
Theoretical pI 4.59
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Transcription factor NF-E2 45 kDa subunit
MSPCPPQQSRNRVIQLSTSELGEMELTWQEIMSITELQGLNAPSEPSFEPQAPAPYLGPP
PPTTYCPCSIHPDSGFPLPPPPYELPASTSHVPDPPYSYGNMAIPVSKPLSLSGLLSEPL
QDPLALLDIGLPAGPPKPQEDPESDSGLSLNYSDAESLELEGTEAGRRRSEYVEMYPVEY
PYSLMPNSLAHSNYTLPAAETPLALEPSSGPVRAKPTARGEAGSRDERRALAMKIPFPTD
KIVNLPVDDFNELLARYPLTESQLALVRDIRRRGKNKVAAQNCRKRKLETIVQLERELER
LTNERERLLRARGEADRTLEVMRQQLTELYRDIFQHLRDESGNSYSPEEYALQQAADGTI
FLVPRGTKMEATD
GenBank ID Protein 13477165
UniProtKB/Swiss-Prot ID Q16621
UniProtKB/Swiss-Prot Entry Name NFE2_HUMAN
PDB IDs Not Available
GenBank Gene ID BC005044
GeneCard ID NFE2
GenAtlas ID NFE2
HGNC ID HGNC:7780
References
General References Not Available