| Identification |
|---|
| HMDB Protein ID
| CDBP00786 |
| Secondary Accession Numbers
| Not Available |
| Name
| 4-hydroxyphenylpyruvate dioxygenase |
| Description
| Not Available |
| Synonyms
|
- 4-hydroxyphenylpyruvic acid oxidase
- 4HPPD
- HPD
- HPPDase
|
| Gene Name
| HPD |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in 4-hydroxyphenylpyruvate dioxygenase activity |
| Specific Function
| Key enzyme in the degradation of tyrosine.
|
| GO Classification
|
| Biological Process |
| cellular nitrogen compound metabolic process |
| L-phenylalanine catabolic process |
| tyrosine catabolic process |
| Cellular Component |
| endoplasmic reticulum membrane |
| cytosol |
| Golgi membrane |
| Function |
| catalytic activity |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| oxidoreductase activity |
| 4-hydroxyphenylpyruvate dioxygenase activity |
| Molecular Function |
| metal ion binding |
| 4-hydroxyphenylpyruvate dioxygenase activity |
| Process |
| cellular amino acid and derivative metabolic process |
| cellular amino acid metabolic process |
| aromatic amino acid family metabolic process |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | L-phenylalanine degradation | Not Available | Not Available | | Ubiquinone and other terpenoid-quinone biosynthesis | Not Available |  | | Phenylalanine metabolism | Not Available |  | | Phenylalanine and Tyrosine Metabolism |    | | | Phenylketonuria |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12q24-qter |
| SNPs
| HPD |
| Gene Sequence
|
>1182 bp
ATGACGACTTACAGTGACAAAGGGGCAAAGCCTGAGAGAGGCCGATTCCTCCACTTCCAC
TCTGTGACCTTCTGGGTTGGCAACGCCAAGCAGGCCGCGTCATTCTACTGCAGCAAGATG
GGCTTTGAACCTCTAGCCTACAGGGGCCTGGAGACCGGTTCCCGGGAGGTGGTCAGCCAT
GTAATCAAACAAGGGAAGATTGTGTTTGTCCTCTCCTCAGCGCTCAACCCCTGGAACAAA
GAGATGGGCGATCACCTGGTGAAACACGGTGACGGAGTGAAGGACATTGCGTTCGAGGTG
GAAGATTGTGACTACATCGTGCAGAAAGCACGGGAACGGGGCGCCAAAATCATGCGGGAG
CCCTGGGTAGAGCAAGACAAGTTTGGGAAGGTGAAGTTTGCTGTGCTGCAGACGTATGGG
GACACCACACACACCCTGGTGGAGAAGATGAACTACATCGGCCAATTCTTGCCTGGATAT
GAGGCCCCAGCGTTCATGGACCCCCTACTTCCTAAACTGCCCAAATGCAGTCTGGAGATG
ATCGACCACATTGTGGGAAACCAGCCTGATCAGGAGATGGTGTCCGCCTCCGAATGGTAC
CTGAAAAACCTGCAGTTCCACCGCTTCTGGTCCGTGGATGACACGCAGGTGCACACGGAA
TATAGCTCTCTGCGATCCATTGTGGTGGCCAACTATGAAGAGTCCATCAAGATGCCCATC
AATGAGCCAGCGCCTGGCAAGAAGAAGTCCCAGATCCAGGAATATGTGGACTATAACGGG
GGCGCTGGGGTCCAGCACATCGCTCTCAAGACCGAAGACATCATCACAGCGATTCGCCAC
TTGAGAGAGAGAGGCCTGGAGTTCTTATCTGTTCCCTCCACGTACTACAAACAACTGCGG
GAGAAGCTGAAGACGGCCAAGATCAAGGTGAAGGAGAACATTGATGCCCTGGAGGAGCTG
AAAATCCTGGTGGACTACGACGAGAAAGGCTACCTCCTGCAGATCTTCACCAAACCGGTG
CAGGACCGGCCCACGCTCTTCCTGGAAGTCATCCAGCGCCACAACCACCAGGGTTTTGGA
GCCGGCAACTTCAACTCACTGTTCAAGGCTTTCGAGGAGGAGCAGAACCTGCGGGGTAAC
CTCACCAACATGGAGACCAATGGGGTGGTGCCCGGCATGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 393 |
| Molecular Weight
| 40497.105 |
| Theoretical pI
| 6.343 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>4-hydroxyphenylpyruvate dioxygenase
MTTYSDKGAKPERGRFLHFHSVTFWVGNAKQAASFYCSKMGFEPLAYRGLETGSREVVSH
VIKQGKIVFVLSSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDYIVQKARERGAKIMRE
PWVEQDKFGKVKFAVLQTYGDTTHTLVEKMNYIGQFLPGYEAPAFMDPLLPKLPKCSLEM
IDHIVGNQPDQEMVSASEWYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPI
NEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLR
EKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIFTKPVQDRPTLFLEVIQRHNHQGFG
AGNFNSLFKAFEEEQNLRGNLTNMETNGVVPGM
|
| External Links |
|---|
| GenBank ID Protein
| 288105 |
| UniProtKB/Swiss-Prot ID
| P32754 |
| UniProtKB/Swiss-Prot Entry Name
| HPPD_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X72389 |
| GeneCard ID
| HPD |
| GenAtlas ID
| HPD |
| HGNC ID
| HGNC:5147 |
| References |
|---|
| General References
| Not Available |