Identification
HMDB Protein ID CDBP01757
Secondary Accession Numbers Not Available
Name Superoxide dismutase [Cu-Zn]
Description Not Available
Synonyms
  1. Superoxide dismutase 1
  2. hSod1
Gene Name SOD1
Protein Type Enzyme
Biological Properties
General Function Involved in metal ion binding
Specific Function Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
GO Classification
Biological Process
response to amphetamine
response to heat
regulation of multicellular organism growth
neurofilament cytoskeleton organization
sensory perception of sound
cell aging
peripheral nervous system myelin maintenance
locomotory behavior
auditory receptor cell stereocilium organization
regulation of organ growth
spermatogenesis
relaxation of vascular smooth muscle
regulation of T cell differentiation in thymus
apoptotic DNA fragmentation
superoxide anion generation
retina homeostasis
embryo implantation
regulation of blood pressure
retrograde axon cargo transport
heart contraction
response to nutrient levels
thymus development
muscle cell homeostasis
removal of superoxide radicals
regulation of mitochondrial membrane potential
double-strand break repair
positive regulation of apoptotic process
placenta development
positive regulation of cytokine production
platelet activation
response to hydrogen peroxide
response to drug
platelet degranulation
response to axon injury
response to ethanol
anterograde axon cargo transport
response to copper ion
hydrogen peroxide biosynthetic process
negative regulation of neuron apoptotic process
activation of MAPK activity
cellular iron ion homeostasis
myeloid cell homeostasis
ovarian follicle development
glutathione metabolic process
negative regulation of cholesterol biosynthetic process
Cellular Component
mitochondrial matrix
nucleus
neuronal cell body
extracellular space
peroxisome
extracellular matrix
dendrite cytoplasm
cytoplasmic vesicle
protein complex
cytosol
Function
ion binding
cation binding
metal ion binding
binding
Molecular Function
protein phosphatase 2B binding
superoxide dismutase activity
zinc ion binding
protein homodimerization activity
copper ion binding
Process
metabolic process
cellular metabolic process
oxidation reduction
oxygen and reactive oxygen species metabolic process
superoxide metabolic process
Cellular Location
  1. Cytoplasm
Pathways
Gene Properties
Chromosome Location 21
Locus 21q22.11
SNPs SOD1
Gene Sequence
>465 bp
ATGGCGACGAAGGCCGTGTGCGTGCTGAAGGGCGACGGCCCAGTGCAGGGCATCATCAAT
TTCGAGCAGAAGGAAAGTAATGGACCAGTGAAGGTGTGGGGAAGCATTAAAGGACTGACT
GAAGGCCTGCATGGATTCCATGTTCATGAGTTTGGAGATAATACAGCAGGCTGTACCAGT
GCAGGTCCTCACTTTAATCCTCTATCCAGAAAACACGGTGGGCCAAAGGATGAAGAGAGG
CATGTTGGAGACTTGGGCAATGTGACTGCTGACAAAGATGGTGTGGCCGATGTGTCTATT
GAAGATTCTGTGATCTCACTCTCAGGAGACCATTGCATCATTGGCCGCACACTGGTGGTC
CATGAAAAAGCAGATGACTTGGGCAAAGGTGGAAATGAAGAAAGTACAAAGACAGGAAAC
GCTGGAAGTCGTTTGGCTTGTGGTGTAATTGGGATCGCCCAATAA
Protein Properties
Number of Residues 154
Molecular Weight 15935.685
Theoretical pI 6.122
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Superoxide dismutase [Cu-Zn]
MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTS
AGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVV
HEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
GenBank ID Protein 36542
UniProtKB/Swiss-Prot ID P00441
UniProtKB/Swiss-Prot Entry Name SODC_HUMAN
PDB IDs
GenBank Gene ID X02317
GeneCard ID SOD1
GenAtlas ID SOD1
HGNC ID HGNC:11179
References
General References Not Available