Cannabis Compound Database: Showing Protein Uroporphyrinogen decarboxylase (CDBP00244)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP00244

Secondary Accession Numbers

Not Available

Name

Uroporphyrinogen decarboxylase

Description

Not Available

Synonyms

UPD
URO-D

Gene Name

UROD

Protein Type

Enzyme

Biological Properties

General Function

Involved in uroporphyrinogen decarboxylase activity

Specific Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.

GO Classification

Biological Process
response to methylmercury
response to mercury ion
small molecule metabolic process
cellular response to arsenic-containing substance
heme biosynthetic process
protoporphyrinogen IX biosynthetic process
response to iron ion
uroporphyrinogen III metabolic process
response to fungicide
liver development
response to ethanol
response to estradiol stimulus
response to amine stimulus
Cellular Component
cytosol
microtubule cytoskeleton
nucleus
Function
catalytic activity
lyase activity
carbon-carbon lyase activity
carboxy-lyase activity
uroporphyrinogen decarboxylase activity
Molecular Function
ferrous iron binding
uroporphyrinogen decarboxylase activity
Process
porphyrin metabolic process
physiological process
metabolism
porphyrin biosynthetic process
heterocycle metabolism
porphyrin metabolism
porphyrin biosynthesis
metabolic process
nitrogen compound metabolic process
cellular metabolism
tetrapyrrole metabolic process

Cellular Location

Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
Porphyrin Metabolism
protoporphyrin-IX biosynthesis	Not Available	Not Available
Porphyrin and chlorophyll metabolism	Not Available
Acute Intermittent Porphyria		Not Available
Porphyria Variegata (PV)		Not Available

Gene Properties

Chromosome Location

Locus

1p34

SNPs

UROD

Gene Sequence

>1104 bp
ATGGAAGCGAATGGGTTGGGACCTCAGGGTTTTCCGGAGCTGAAGAATGACACATTCCTG
CGAGCAGCTTGGGGAGAGGAAACAGACTACACTCCCGTTTGGTGCATGCGCCAGGCAGGC
CGTTACTTACCAGAGTTTAGGGAAACCCGGGCTGCCCAGGACTTTTTCAGCACGTGTCGC
TCTCCTGAGGCCTGCTGTGAACTGACTCTGCAGCCACTGCGTCGCTTCCCTCTGGATGCT
GCCATCATTTTCTCCGACATCCTTGTTGTACCCCAGGCACTGGGCATGGAGGTGACCATG
GTACCTAGCAAAGGACCCAGCTTCCCAGAGCCATTAAGAGAAGAGCAGGACCTAGAAGCG
CTACGGGATCCAGAAGTGGTAGCCTCTGAGCTAGGCTATGTGTTCCAAGCCATCACCCTT
ACCCGACAACGACTGGCTGGACGTGTGCCGCTGATTGGCTTTGCTGGTGCCCCATGGACC
CTGATGACATACATGGTTGAGGGTGGTGGCTCAAGCACCATGGCTCAGGCCAAGCGCTGG
CTCTATCAGAGACCTCAGGCTAGTCACCAGCTGCTTCGCATCCTCACTGATGCTCTGGTC
CCATATCTGGTAGGACAAGTGGTGGCTGGTGCCCAGGCATTGCAGCTGTTTGAGTCCCAT
GCAGGGCATCTTGGCCCACAGCTCTTCAACAAGTTTGCACTGCCTTACATCCGTGATGTG
GCCAAGCAAGTGAAGGCCAGGTTGCGGGAGGCAGGCCTGGCACCAGTGCCCATGATCATC
TTTGCTAAGGATGGGCATTTTGCCCTGGAGGAGCTGGCCCAAGCTGGCTATGAGGTGGTT
GGGCTTGACTGGACAGTGGCCCCAAAGAAAGCCCGGGAGTGTGTGGGGAAGACGGTGACA
TTGCAGGGCAACTTGGACCCCTGTGCCTTGTATGCATCTGAGGAGGAGATCGGGCAGTTG
GTGAAGCAGATGCTGGATGACTTTGGACCACATCGCTACATTGCCAACTTGGGCCATGGG
CTTTATCCTGACATGGACCCAGAACATGTGGGCGCCTTTGTGGATGCTGTGCATAAACAC
TCACGTCTGCTTCGACAGAACTGA

Protein Properties

Number of Residues

367

Molecular Weight

40786.58

Theoretical pI

6.139

Pfam Domain Function

URO-D (PF01208 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Uroporphyrinogen decarboxylase
MEANGLGPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCR
SPEACCELTLQPLRRFPLDAAIIFSDILVVPQALGMEVTMVPGKGPSFPEPLREEQDLER
LRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMAQAKRW
LYQRPQASHQLLRILTDALVPYLVGQVVAGAQALQLFESHAGHLGPQLFNKFALPYIRDV
AKQVKARLREAGLAPVPMIIFAKDGHFALEELAQAGYEVVGLDWTVAPKKARECVGKTVT
LQGNLDPCALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKH
SRLLRQN

External Links

GenBank ID Protein

340181

UniProtKB/Swiss-Prot ID

P06132

UniProtKB/Swiss-Prot Entry Name

DCUP_HUMAN

PDB IDs