| Identification |
|---|
| HMDB Protein ID
| CDBP03882 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ferritin heavy chain |
| Description
| Not Available |
| Synonyms
|
- Cell proliferation-inducing gene 15 protein
- Ferritin H subunit
|
| Gene Name
| FTH1 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
|
| GO Classification
|
| Biological Process |
| intracellular sequestering of iron ion |
| iron ion transport |
| negative regulation of fibroblast proliferation |
| immune response |
| cellular membrane organization |
| post-Golgi vesicle-mediated transport |
| transmembrane transport |
| Cellular Component |
| cytosol |
| intracellular ferritin complex |
| mitochondrion |
| Function |
| catalytic activity |
| transition metal ion binding |
| iron ion binding |
| oxidoreductase activity |
| ferric iron binding |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| Molecular Function |
| ferric iron binding |
| ferroxidase activity |
| iron ion binding |
| Process |
| transition metal ion transport |
| iron ion transport |
| regulation of biological quality |
| homeostatic process |
| chemical homeostasis |
| ion homeostasis |
| cellular ion homeostasis |
| cellular cation homeostasis |
| cellular di-, tri-valent inorganic cation homeostasis |
| metabolic process |
| establishment of localization |
| cellular iron ion homeostasis |
| transport |
| biological regulation |
| oxidation reduction |
| ion transport |
| cation transport |
| metal ion transport |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Porphyrin and chlorophyll metabolism | Not Available |  | | Mineral absorption | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11q13 |
| SNPs
| FTH1 |
| Gene Sequence
|
>552 bp
ATGACGACCGCGTCCACCTCGCAGGTGCGCCAGAACTACCACCAGGACTCAGAGGCCGCC
ATCAACCGCCAGATCAACCTGGAGCTCTACGCCTCCTACGTTTACCTGTCCATGTCTTAC
TACTTTGACCGCGATGATGTGGCTTTGAAGAACTTTGCCAAATACTTTCTTCACCAATCT
CATGAGGAGAGGGAACATGCTGAGAAACTGATGAAGCTGCAGAACCAACGAGGTGGCCGA
ATCTTTCTTCAGGATATCAAGAAACCAGACTGTGATGACTGGGAGAGCGGGCTGAATGCA
ATGGAGTGTGCATTACATTTGGAAAAAAATGTGAATCAGTCACTACTGGAACTGCACAAA
CTGGCCACTGACAAAAATGACCCCCATTTGTGTGACTTCATTGAGACACATTACCTGAAT
GAGCAGGTGAAAGCCATCAAAGAATTGGGTGACCACGTGACCAACTTGCGCAAGATGGGA
GCGCCCGAATCTGGCTTGGCGGAATATCTCTTTGACAAGCACACCCTGGGAGACAGTGAT
AATGAAAGCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 183 |
| Molecular Weight
| 21225.47 |
| Theoretical pI
| 5.556 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Ferritin heavy chain
MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQS
HEEREHAEKLMKLQNQRGGRIFLQDIKKPDCDDWESGLNAMECALHLEKNVNQSLLELHK
LATDKNDPHLCDFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLGDSD
NES
|
| External Links |
|---|
| GenBank ID Protein
| 21104438 |
| UniProtKB/Swiss-Prot ID
| P02794 |
| UniProtKB/Swiss-Prot Entry Name
| FRIH_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB062402 |
| GeneCard ID
| FTH1 |
| GenAtlas ID
| FTH1 |
| HGNC ID
| HGNC:3976 |
| References |
|---|
| General References
| Not Available |