Showing Protein Superoxide dismutase [Mn], mitochondrial (CDBP01701)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 7 compounds
Identification
HMDB Protein ID CDBP01701
Secondary Accession Numbers Not Available
Name Superoxide dismutase [Mn], mitochondrial
Description Not Available
Synonyms Not Available
Gene Name SOD2
Protein Type Enzyme
Biological Properties
General Function Involved in superoxide dismutase activity
Specific Function Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
GO Classification
Biological Process
response to drug
response to zinc ion
response to hydrogen peroxide
hydrogen peroxide biosynthetic process
response to electrical stimulus
response to axon injury
glutathione metabolic process
negative regulation of neuron apoptotic process
response to hypoxia
heart development
age-dependent response to reactive oxygen species
response to manganese ion
hemopoiesis
erythrophore differentiation
respiratory electron transport chain
detection of oxygen
negative regulation of fibroblast proliferation
post-embryonic development
positive regulation of nitric oxide biosynthetic process
negative regulation of fat cell differentiation
regulation of transcription from RNA polymerase II promoter
regulation of catalytic activity
superoxide anion generation
response to silicon dioxide
response to activity
vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure
response to selenium ion
response to lipopolysaccharide
oxygen homeostasis
protein homotetramerization
response to gamma radiation
locomotory behavior
negative regulation of cell proliferation
response to L-ascorbic acid
cellular response to ethanol
release of cytochrome c from mitochondria
regulation of mitochondrial membrane potential
neuron development
removal of superoxide radicals
iron ion homeostasis
response to cadmium ion
response to hyperoxia
liver development
Cellular Component
mitochondrial matrix
mitochondrial nucleoid
mitochondrial inner membrane
Function
ion binding
cation binding
metal ion binding
binding
antioxidant activity
superoxide dismutase activity
Molecular Function
manganese ion binding
superoxide dismutase activity
DNA binding
oxygen binding
Process
metabolic process
cellular metabolic process
oxidation reduction
oxygen and reactive oxygen species metabolic process
superoxide metabolic process
Cellular Location
  1. Mitochondrion matrix
Pathways
Gene Properties
Chromosome Location 6
Locus 6q25.3
SNPs SOD2
Gene Sequence 
>669 bp
ATGTTGAGCCGGGCAGTGTGCGGCACCAGCAGGCAGCTGGCTCCGGCTTTGGGGTATCTG
GGCTCCAGGCAGAAGCACAGCCTCCCCGACCTGCCCTACGACTACGGCGCCCTGGAACCT
CACATCAACGCGCAGATCATGCAGCTGCACCACAGCAAGCACCACGCGGCCTACGTGAAC
AACCTGAACGTCAACGAGGAGAAGTACCAGGAGGCGTTGGCCAAGGGAGATGTTACAGCC
CAGATAGCTCTTCAGCCTGCACTGAAGTTCAATGGTGGTGGTCATATCAATCATAGCATT
TTCTGGACAAACCTCAGCCCTAACGGTGGTGGAGAACCCAAAGGGGAGTTGCTGGAAGCC
ATCAAACGTGACTTTGGTTCCTTTGACAAGTTTAAGGAGAAGCTGACGGCTGCATCTGTT
GGTGTCCAAGGCTCAGGTTGGGGTTGGCTTGGTTTCAATAAGGAACGGGGACACTTACAA
ATTGCTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGCTG
GGGATTGATGTGTGGGAGCACGCTTACTACCTTCAGTATAAAAATGTCAGGCCTGATTAT
CTAAAAGCTATTTGGAATGTAATCAACTGGGAGAATGTAACTGAAAGATACATGGCTTGC
AAAAAGTAA
Protein Properties
Number of Residues 222
Molecular Weight 24750.015
Theoretical pI 8.256
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Superoxide dismutase [Mn], mitochondrial
MLSRAVCGTSRQLAPALGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVN
NLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEA
IKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLL
GIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK
GenBank ID Protein 34709
UniProtKB/Swiss-Prot ID P04179
UniProtKB/Swiss-Prot Entry Name SODM_HUMAN
PDB IDs
GenBank Gene ID X59445
GeneCard ID SOD2
GenAtlas ID SOD2
HGNC ID HGNC:11180
References
General References Not Available