Identification
HMDB Protein ID CDBP00267
Secondary Accession Numbers Not Available
Name Tyrosine 3-monooxygenase
Description Not Available
Synonyms
  1. TH
  2. Tyrosine 3-hydroxylase
Gene Name TH
Protein Type Enzyme
Biological Properties
General Function Involved in monooxygenase activity
Specific Function Plays an important role in the physiology of adrenergic neurons.
GO Classification
Biological Process
response to water deprivation
response to zinc ion
isoquinoline alkaloid metabolic process
synaptic transmission, dopaminergic
cellular nitrogen compound metabolic process
regulation of heart contraction
terpene metabolic process
cellular response to drug
learning
response to salt stress
response to electrical stimulus
response to nutrient levels
neurotransmitter biosynthetic process
response to light stimulus
response to activity
cellular response to glucose stimulus
mating behavior
visual perception
fatty acid metabolic process
phthalate metabolic process
heart morphogenesis
cerebral cortex development
multicellular organismal aging
norepinephrine biosynthetic process
response to ethanol
circadian sleep/wake cycle
response to corticosterone stimulus
cellular response to manganese ion
response to lipopolysaccharide
pigmentation
cellular response to growth factor stimulus
cellular response to nicotine
phytoalexin metabolic process
eating behavior
response to amphetamine
dopamine biosynthetic process from tyrosine
response to estradiol stimulus
social behavior
response to pyrethroid
response to hypoxia
sensory perception of sound
memory
eye photoreceptor cell development
response to ether
response to herbicide
locomotory behavior
response to peptide hormone stimulus
synaptic vesicle amine transport
embryonic camera-type eye morphogenesis
sphingolipid metabolic process
epinephrine biosynthetic process
Cellular Component
cytosol
mitochondrion
dendrite
melanosome membrane
nucleus
synaptic vesicle
terminal button
internal side of plasma membrane
perikaryon
smooth endoplasmic reticulum
neuron projection
Function
iron ion binding
monooxygenase activity
oxidoreductase activity
tyrosine 3-monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
ion binding
cation binding
metal ion binding
binding
catalytic activity
transition metal ion binding
Molecular Function
ferrous iron binding
oxygen binding
ferric iron binding
tyrosine 3-monooxygenase activity
dopamine binding
tetrahydrobiopterin binding
amino acid binding
Process
cellular biogenic amine metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
catecholamine metabolic process
catecholamine biosynthetic process
aromatic amino acid family metabolic process
metabolic process
cellular metabolic process
oxidation reduction
cellular amino acid derivative metabolic process
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 11
Locus 11p15.5
SNPs TH
Gene Sequence
>1587 bp
ATGCCCACCCCCGACGCCACCACGCCACAGGCCAAGGGCTTCCGCAGGGCCGTGTCTGAG
CTGGACGCCAAGCAGGCAGAGGCCATCATGGTAAGAGGGCAGGGCGCCCCGGGGCCCAGC
CTCACAGGCTCTCCGTGGCCTGGAACTGCAGCCCCAGCTGCATCCTACACCCCCACCCCA
AGGTCCCCGCGGTTCATTGGGCGCAGGCAGAGCCTCATCGAGGACGCCCGCAAGGAGCGG
GAGGCGGCGGTGGCAGCAGCGGCCGCTGCAGTCCCCTCGGAGCCCGGGGACCCCCTGGAG
GCTGTGGCCTTTGAGGAGAAGGAGGGGAAGGCCGTGCTAAACCTGCTCTTCTCCCCGAGG
GCCACCAAGCCCTCGGCGCTGTCCCGAGCTGTGAAGGTGTTTGAGACGTTTGAAGCCAAA
ATCCACCATCTAGAGACCCGGCCCGCCCAGAGGCCGCGAGCTGGGGGCCCCCACCTGGAG
TACTTCGTGCGCCTCGAGGTGCGCCGAGGGGACCTGGCCGCCCTGCTCAGTGGTGTGCGC
CAGGTGTCAGAGGACGTGCGCAGCCCCGCGGGGCCCAAGGTCCCCTGGTTCCCAAGAAAA
GTGTCAGAGCTGGACAAGTGTCATCACCTGGTCACCAAGTTCGACCCTGACCTGGACTTG
GACCACCCGGGCTTCTCGGACCAGGTGTACCGCCAGCGCAGGAAGCTGATTGCTGAGATC
GCCTTCCAGTACAGGCACGGCGACCCGATTCCCCGTGTGGAGTACACCGCCGAGGAGATT
GCCACCTGGAAGGAGGTCTACACCACGCTGAAGGGCCTCTACGCCACGCACGCCTGCGGG
GAGCACCTGGAGGCCTTTGCTTTGCTGGAGCGCTTCAGCGGCTACCGGGAAGACAATATC
CCCCAGCTGGAGGACGTCTCCCGCTTCCTGAAGGAGCGCACGGGCTTCCAGCTGCGGCCT
GTGGCCGGCCTGCTGTCCGCCCGGGACTTCCTGGCCAGCCTGGCCTTCCGCGTGTTCCAG
TGCACCCAGTATATCCGCCACGCGTCCTCGCCCATGCACTCCCCTGAGCCGGACTGCTGC
CACGAGCTGCTGGGGCACGTGCCCATGCTGGCCGACCGCACCTTCGCGCAGTTCTCGCAG
GACATTGGCCTGGCGTCCCTGGGGGCCTCGGATGAGGAAATTGAGAAGCTGTCCACGCTG
TCATGGTTCACGGTGGAGTTCGGGCTGTGTAAGCAGAACGGGGAGGTGAAGGCCTATGGT
GCCGGGCTGCTGTCCTCCTACGGGGAGCTCCTGCACTGCCTGTCTGAGGAGCCTGAGATT
CGGGCCTTCGACCCTGAGGCTGCGGCCGTGCAGCCCTACCAAGACCAGACGTACCAGTCA
GTCTACTTCGTGTCTGAGAGCTTCAGTGACGCCAAGGACAAGCTCAGGAGCTATGCCTCA
CGCATCCAGCGCCCCTTCTCCGTGAAGTTCGACCCGTACACGCTGGCCATCGACGTGCTG
GACAGCCCCCAGGCCGTGCGGCGCTCCCTGGAGGGTGTCCAGGATGAGCTGGACACCCTT
GCCCATGCGCTGAGTGCCATTGGCTAG
Protein Properties
Number of Residues 528
Molecular Weight 55611.26
Theoretical pI 6.109
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Tyrosine 3-monooxygenase
MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTAAPAASYTPTP
RSPRFIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPR
ATKPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVR
QVSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEI
AFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNI
PQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCC
HELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYG
AGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYAS
RIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG
GenBank ID Protein 339681
UniProtKB/Swiss-Prot ID P07101
UniProtKB/Swiss-Prot Entry Name TY3H_HUMAN
PDB IDs
GenBank Gene ID M17589
GeneCard ID TH
GenAtlas ID TH
HGNC ID HGNC:11782
References
General References Not Available