Cannabis Compound Database: Showing Protein Serine/threonine-protein phosphatase PP1-beta catalytic subunit (CDBP01596)

Identification Biological properties Gene properties Protein properties External links References XML Show 4 compounds

Identification

HMDB Protein ID

CDBP01596

Secondary Accession Numbers

Not Available

Name

Serine/threonine-protein phosphatase PP1-beta catalytic subunit

Description

Not Available

Synonyms

PP-1B
PPP1CD

Gene Name

PPP1CB

Protein Type

Enzyme

Biological Properties

General Function

Involved in hydrolase activity

Specific Function

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

GO Classification

Biological Process
negative regulation of transforming growth factor beta receptor signaling pathway
transforming growth factor beta receptor signaling pathway
regulation of glycogen biosynthetic process
regulation of glycogen catabolic process
regulation of cell adhesion
protein dephosphorylation
small molecule metabolic process
cell cycle
cell division
glycogen metabolic process
triglyceride catabolic process
Cellular Component
nucleolus
protein phosphatase type 1 complex
PTW/PP1 phosphatase complex
glycogen granule
MLL5-L complex
Function
catalytic activity
hydrolase activity
Molecular Function
metal ion binding
myosin phosphatase activity
myosin-light-chain-phosphatase activity

Cellular Location

Nucleus
Nucleus
Nucleus
Cytoplasm
nucleolus
nucleoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
mRNA surveillance pathway	Not Available
Oocyte meiosis	Not Available
Vascular smooth muscle contraction	Not Available
Hippo signaling pathway	Not Available
Focal adhesion	Not Available

Gene Properties

Chromosome Location

Locus

2p23

SNPs

PPP1CB

Gene Sequence

>984 bp
ATGGCGGACGGGGAGCTGAACGTGGACAGCCTCATCACCCGGCTGCTGGAGGTACGAGGA
TGTCGTCCAGGAAAGATTGTGCAGATGACTGAAGCAGAAGTTCGAGGCTTATGTATCAAG
TCTCGGGAGATCTTTCTCAGCCAGCCTATTCTTTTGGAATTGGAAGCACCGCTGAAAATT
TGTGGAGATATTCATGGACAATATACAGATTTACTGAGATTATTTGAATATGGAGGTTTC
CCACCAGAAGCCAACTATCTTTTCTTAGGAGATTATGTGGACAGAGGAAAGCAGTCTTTG
GAAACCATTTGTTTGCTATTGGCTTATAAAATCAAATATCCAGAGAACTTCTTTCTCTTA
AGAGGAAACCATGAGTGTGCTAGCATCAATCGCATTTATGGATTCTATGATGAATGCAAA
CGAAGATTTAATATTAAATTGTGGAAGACCTTCACTGATTGTTTTAACTGTCTGCCTATA
GCAGCCATTGTGGATGAGAAGATCTTCTGTTGTCATGGAGGATTGTCACCAGACCTGCAA
TCTATGGAGCAGATTCGGAGAATTATGAGACCTACTGATGTCCCTGATACAGGTTTGCTC
TGTGATTTGCTATGGTCTGATCCAGATAAGGATGTGCAAGGCTGGGGAGAAAATGATCGT
GGTGTTTCCTTTACTTTTGGAGCTGATGTAGTCAGTAAATTTCTGAATCGTCATGATTTA
GATTTGATTTGTCGAGCTCATCAGGTGGTGGAAGATGGATATGAATTTTTTGCTAAACGA
CAGTTGGTAACCTTATTTTCAGCCCCAAATTACTGTGGCGAGTTTGATAATGCTGGTGGA
ATGATGAGTGTGGATGAAACTTTGATGTGTTCATTTCAGATATTGAAACCATCTGAAAAG
AAAGCTAAATACCAGTATGGTGGACTGAATTCTGGACGTCCTGTCACTCCACCTCGAACA
GCTAATCCGCCGAAGAAAAGGTGA

Protein Properties

Number of Residues

327

Molecular Weight

37186.45

Theoretical pI

6.183

Pfam Domain Function

Metallophos (PF00149 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Serine/threonine-protein phosphatase PP1-beta catalytic subunit
MADGELNVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKI
CGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLL
RGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQ
SMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDL
DLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEK
KAKYQYGGLNSGRPVTPPRTANPPKKR

External Links

GenBank ID Protein

531476

UniProtKB/Swiss-Prot ID

P62140

UniProtKB/Swiss-Prot Entry Name

PP1B_HUMAN

PDB IDs

Not Available

GenBank Gene ID

X80910

GeneCard ID