| Identification |
|---|
| HMDB Protein ID
| CDBP00785 |
| Secondary Accession Numbers
| Not Available |
| Name
| Inositol oxygenase |
| Description
| Not Available |
| Synonyms
|
- Aldehyde reductase-like 6
- Kidney-specific protein 32
- MI oxygenase
- Myo-inositol oxygenase
- Renal-specific oxidoreductase
- SubName: Myo-inositol oxygenase
- SubName: Myo-inositol oxygenase, isoform CRA_d
|
| Gene Name
| MIOX |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in iron ion binding |
| Specific Function
| Not Available |
| GO Classification
|
| Biological Process |
| inositol catabolic process |
| Cellular Component |
| cytoplasm |
| inclusion body |
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Function |
| transition metal ion binding |
| iron ion binding |
| oxidoreductase activity |
| inositol oxygenase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen |
| Molecular Function |
| ferric iron binding |
| NADP binding |
| aldo-keto reductase (NADP) activity |
| oxidoreductase activity, acting on NADH or NADPH |
| inositol oxygenase activity |
| Process |
| metabolic process |
| small molecule metabolic process |
| alcohol metabolic process |
| polyol metabolic process |
| oxidation reduction |
| inositol metabolic process |
| inositol catabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Inositol Metabolism |    |  | | myo-inositol degradation into D-glucuronate | Not Available | Not Available | | Ascorbate and aldarate metabolism | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| 22q13.3 |
| SNPs
| MIOX |
| Gene Sequence
|
>858 bp
ATGAAGGTCGATGTGGGCCCAGACCCTTCCCTGGTCTACCGACCTGATGTGGACCCAGAG
GTGGCCAAAGACAAGGCCAGCTTCCGGAACTACACGTCAGGTCCCCTCCTGGACCGTGTC
TTCACCACCTACAAGCTCATGCACACGCACCAGACAGTGGACTTCGTCAGGAGCAAGCAT
GCCCAGTTTGGGGGCTTCTCCTACAAGAAAATGACAGTCATGGAGGCCGTGGACCTGCTG
GATGGGCTGGTGGATGAGTCGGACCCGGACGTAGATTTCCCCAACTCCTTCCATGCCTTC
CAGACAGCGGAGGGCATCCGGAAGGCCCACCCAGACAAGGACTGGTTCCACCTCGTCGGG
CTCCTGCACGACCTGGGGAAGGTCCTGGCCCTGTTCGGGGAGCCCCAGTGGGCTGTCGTC
GGCGACACCTTCCCCGTCGGATGCCGTCCGCAGGCCTCCGTGGTTTTCTGCGACTCCACC
TTCCAGGACAACCCTGACCTCCAGGATCCTCGATACAGCACAGAGCTCGGGATGTATCAG
CCCCACTGTGGGCTCGACAGGGTCCTCATGTCCTGGGGCCATGATGAGTACATGTACCAG
GTGATGAAGTTTAACAAGTTCTCACTGCCCCCTGAGGCTTTCTACATGATCCGGTTCCAC
TCCTTCTACCCCTGGCACACGGGCCGCGACTACCAGCAGCTGTGCAGCCAGCAGGACCTG
GCCATGCTGCCCTGGGTGCGGGAGTTCAACAAGTTCGACCTCTACACCAAGTGCCCGGAC
CTGCCGGACGTGGACAAGCTGCGGCCCTACTACCAGGGGCTCATTGACAAGTACTGCCCG
GGCACCCTGAGCTGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 285 |
| Molecular Weight
| 33009.33 |
| Theoretical pI
| 5.89 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Inositol oxygenase
MKVTVGPDPSLVYRPDVDPEVAKDKASFRNYTSGPLLDRVFTTYKLMHTHQTVDFVRSKH
AQFGGFSYKKMTVMEAVDLLDGLVDESDPDVDFPNSFHAFQTAEGIRKAHPDKDWFHLVG
LLHDLGKVLALFGEPQWAVVGDTFPVGCRPQASVVFCDSTFQDNPDLQDPRYSTELGMYQ
PHCGLDRVLMSWGHDEYMYQVMKFNKFSLPPEAFYMIRFHSFYPWHTGRDYQQLCSQQDL
AMLPWVREFNKFDLYTKCPDLPDVDKLRPYYQGLIDKYCPGILSW
|
| External Links |
|---|
| GenBank ID Protein
| 6694290 |
| UniProtKB/Swiss-Prot ID
| Q9UGB7 |
| UniProtKB/Swiss-Prot Entry Name
| MIOX_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF197129 |
| GeneCard ID
| MIOX |
| GenAtlas ID
| MIOX |
| HGNC ID
| HGNC:14522 |
| References |
|---|
| General References
| Not Available |