| Identification |
|---|
| HMDB Protein ID
| CDBP00914 |
| Secondary Accession Numbers
| Not Available |
| Name
| Prostaglandin G/H synthase 1 |
| Description
| Not Available |
| Synonyms
|
- COX-1
- Cyclooxygenase-1
- PGH synthase 1
- PGHS-1
- PHS 1
- Prostaglandin H2 synthase 1
- Prostaglandin-endoperoxide synthase 1
|
| Gene Name
| PTGS1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in peroxidase activity |
| Specific Function
| May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.
|
| GO Classification
|
| Biological Process |
| positive regulation of smooth muscle contraction |
| cyclooxygenase pathway |
| negative regulation of norepinephrine secretion |
| regulation of cell proliferation |
| positive regulation of vasoconstriction |
| negative regulation of epinephrine secretion |
| response to organic nitrogen |
| response to oxidative stress |
| xenobiotic metabolic process |
| regulation of blood pressure |
| aging |
| response to corticosterone stimulus |
| Cellular Component |
| endoplasmic reticulum membrane |
| photoreceptor outer segment |
| nucleus |
| nuclear envelope |
| Function |
| peroxidase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| iron ion binding |
| antioxidant activity |
| heme binding |
| Molecular Function |
| lipid binding |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| heme binding |
| peroxidase activity |
| prostaglandin-endoperoxide synthase activity |
| metal ion binding |
| Process |
| response to stimulus |
| response to stress |
| response to oxidative stress |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Peripheral membrane protein
- Peripheral membrane protein
- Endoplasmic reticulum membrane
- Microsome membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | prostaglandin biosynthesis | Not Available | Not Available | | Serotonergic synapse | Not Available |  | | Arachidonic Acid Metabolism |    |  | | Leukotriene C4 Synthesis Deficiency |    | Not Available | | Piroxicam Action Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| 9q32-q33.3 |
| SNPs
| PTGS1 |
| Gene Sequence
|
>1800 bp
ATGAGCCGGAGTCTCTTGCTCCGGTTCTTGCTGTTCCTGCTCCTGCTCCCGCCGCTCCCC
GTCCTGCTCGCGGACCCAGGGGCGCCCACGCCAGTGAATCCCTGTTGTTACTATCCATGC
CAGCACCAGGGCATCTGTGTCCGCTTCGGCCTTGACCGCTACCAGTGTGACTGCACCCGC
ACGGGCTATTCCGGCCCCAACTGCACCATCCCTGGCCTGTGGACCTGGCTCCGGAATTCA
CTGCGGCCCAGCCCCTCTTTCACCCACTTCCTGCTCACTCACGGGCGCTGGTTCTGGGAG
TTTGTCAATGCCACCTTCATCCGAGAGATGCTCATGCGCCTGGTACTCACAGTGCGCTCC
AACCTTATCCCCAGTCCCCCCACCTACAACTCAGCACATGACTACATCAGCTGGGAGTCT
TTCTCCAACGTGAGCTATTACACTCGTATTCTGCCCTCTGTGCCTAAAGATTGCCCCACA
CCCATGGGAACCAAAGGGAAGAAGCAGTTGCCAGATGCCCAGCTCCTGGCCCGCCGCTTC
CTGCTCAGGAGGAAGTTCATACCTGACCCCCAAGGCACCAACCTCATGTTTGCCTTCTTT
GCACAACACTTCACCCACCAGTTCTTCAAAACTTCTGGCAAGATGGGTCCTGGCTTCACC
AAGGCCTTGGGCCATGGGGTAGACCTCGGCCACATTTATGGAGACAATCTGGAGCGTCAG
TATCAACTGCGGCTCTTTAAGGATGGGAAACTCAAGTACCAGGTGCTGGATGGAGAAATG
TACCCGCCCTCGGTAGAAGAGGCGCCTGTGTTGATGCACTACCCCCGAGGCATCCCGCCC
CAGAGCCAGATGGCTGTGGGCCAGGAGGTGTTTGGGCTGCTTCCTGGGCTCATGCTGTAT
GCCACGCTCTGGCTACGTGAGCACAACCGTGTGTGTGACCTGCTGAAGGCTGAGCACCCC
ACCTGGGGCGATGAGCAGCTTTTCCAGACGACCCGCCTCATCCTCATAGGGGAGACCATC
AAGATTGTCATCGAGGAGTACGTGCAGCAGCTGAGTGGCTATTTCCTGCAGCTGAAATTT
GACCCAGAGCTGCTGTTCGGTGTCCAGTTCCAATACCGCAACCGCATTGCCATGGAGTTC
AACCATCTCTACCACTGGCACCCCCTCATGCCTGACTCCTTCAAGGTGGGCTCCCAGGAG
TACAGCTACGAGCAGTTCTTGTTCAACACCTCCATGTTGGTGGACTATGGGGTTGAGGCC
CTGGTGGATGCCTTCTCTCGCCAGATTGCTGGCCGGATCGGTGGGGGCAGGAACATGGAC
CACCACATCCTGCATGTGGCTGTGGATGTCATCAGGGAGTCTCGGGAGATGCGGCTGCAG
CCCTTCAATGAGTACCGCAAGAGGTTTGGCATGAAACCCTACACCTCCTTCCAGGAGCTC
GTAGGAGAGAAGGAGATGGCAGCAGAGTTGGAGGAATTGTATGGAGACATTGATGCGTTG
GAGTTCTACCCTGGACTGCTTCTTGAAAAGTGCCATCCAAACTCTATCTTTGGGGAGAGT
ATGATAGAGATTGGGGCTCCCTTTTCCCTCAAGGGTCTCCTAGGGAATCCCATCTGTTCT
CCGGAGTACTGGAAGCCGAGCACATTTGGCGGCGAGGTGGGCTTTAACATTGTCAAGACG
GCCACACTGAAGAAGCTGGTCTGCCTCAACACCAAGACCTGTCCCTACGTTTCCTTCCGT
GTGCCGGATGCCAGTCAGGATGATGGGCCTGCTGTGGAGCGACCATCCACAGAGCTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 599 |
| Molecular Weight
| 68685.82 |
| Theoretical pI
| 7.232 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Prostaglandin G/H synthase 1
MSRSLLLRFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR
TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS
NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF
LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ
YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY
ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF
DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA
LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL
VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS
PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P23219 |
| UniProtKB/Swiss-Prot Entry Name
| PGH1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| M59979 |
| GeneCard ID
| PTGS1 |
| GenAtlas ID
| PTGS1 |
| HGNC ID
| HGNC:9604 |
| References |
|---|
| General References
| Not Available |