| Identification |
|---|
| HMDB Protein ID
| CDBP00174 |
| Secondary Accession Numbers
| Not Available |
| Name
| Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- CII-4
- CybS
- QPs3
- Succinate dehydrogenase complex subunit D
- Succinate-ubiquinone oxidoreductase cytochrome b small subunit
- Succinate-ubiquinone reductase membrane anchor subunit
|
| Gene Name
| SDHD |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in iron ion binding |
| Specific Function
| Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity).
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| tricarboxylic acid cycle |
| mitochondrial electron transport, succinate to ubiquinone |
| respiratory electron transport chain |
| Cellular Component |
| integral to membrane |
| mitochondrial respiratory chain complex II |
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| envelope |
| organelle envelope |
| mitochondrial envelope |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| iron ion binding |
| heme binding |
| Molecular Function |
| iron ion binding |
| heme binding |
| succinate dehydrogenase activity |
| ubiquinone binding |
| electron carrier activity |
| Process |
| metabolic process |
| cellular metabolic process |
| cofactor metabolic process |
| coenzyme metabolic process |
| acetyl-coa metabolic process |
| acetyl-coa catabolic process |
| tricarboxylic acid cycle |
|
| Cellular Location
|
- Mitochondrion inner membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | tricarboxylic acid cycle | Not Available | Not Available | | Citrate cycle (TCA cycle) | Not Available |  | | Oxidative phosphorylation | Not Available |  | | Alzheimer's disease | Not Available |  | | Parkinson's disease | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11q23 |
| SNPs
| SDHD |
| Gene Sequence
|
>480 bp
ATGGCGGTTCTCTGGAGGCTGAGTGCCGTTTGCGGTGCCCTAGGAGGCCGAGCTCTGTTG
CTTCGAACTCCAGTGGTCAGACCTGCTCATATCTCAGCATTTCTTCAGGACCGACCTATC
CCAGAATGGTGTGGAGTGCAGCACATACACTTGTCACCGAGCCACCATTCTGGCTCCAAG
GCTGCATCTCTCCACTGGACTAGCGAGAGGGTTGTCAGTGTTTTGCTCCTGGGTCTGCTT
CCGGCTGCTTATTTGAATCCTTGCTCTGCGATGGACTATTCCCTGGCTGCAGCCCTCACT
CTTCATGGTCACTGGGGCCTTGGACAAGTTGTTACTGACTATGTTCATGGGGATGCCTTG
CAGAAAGCTGCCAAGGCAGGGCTTTTGGCACTTTCAGCTTTAACCTTTGCTGGGCTTTGC
TATTTCAACTATCACGATGTGGGCATCTGCAAAGCTGTTGCCATGCTGTGGAAGCTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 159 |
| Molecular Weight
| 17042.82 |
| Theoretical pI
| 8.625 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
MAVLWRLSAVCGALGGRALLLRTPVVRPAHISAFLQDRPIPEWCGVQHIHLSPSHHSGSK
AASLHWTSERVVSVLLLGLLPAAYLNPCSAMDYSLAAALTLHGHWGLGQVVTDYVHGDAL
QKAAKAGLLALSALTFAGLCYFNYHDVGICKAVAMLWKL
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O14521 |
| UniProtKB/Swiss-Prot Entry Name
| DHSD_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB006202 |
| GeneCard ID
| SDHD |
| GenAtlas ID
| SDHD |
| HGNC ID
| HGNC:10683 |
| References |
|---|
| General References
| Not Available |