Showing Protein Serine/threonine-protein phosphatase 4 catalytic subunit (CDBP03896)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 4 compounds
Identification
HMDB Protein ID CDBP03896
Secondary Accession Numbers Not Available
Name Serine/threonine-protein phosphatase 4 catalytic subunit
Description Not Available
Synonyms
  1. PP-X
  2. PP4C
  3. Pp4
  4. Protein phosphatase X
Gene Name PPP4C
Protein Type Enzyme
Biological Properties
General Function Involved in hydrolase activity
Specific Function Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
GO Classification
Biological Process
regulation of double-strand break repair via homologous recombination
microtubule cytoskeleton organization
Cellular Component
centrosome
cytoplasm
plasma membrane
nucleus
Function
catalytic activity
hydrolase activity
Molecular Function
protein serine/threonine phosphatase activity
metal ion binding
NF-kappaB-inducing kinase activity
Cellular Location
  1. Nucleus
  2. Cytoplasm
  3. Cytoplasm
  4. cytoskeleton
  5. centrosome
Pathways
Gene Properties
Chromosome Location 16
Locus 16p11.2
SNPs PPP4C
Gene Sequence 
>924 bp
ATGGCGGAGATCAGCGACCTGGACCGGCAGATCGAGCAGCTGCGTCGCTGCGAGCTCATC
AAGGAGAGCGAAGTCAAGGCCCTGTGCGCTAAGGCCAGAGAGATCTTGGTAGAGGAGAGC
AACGTGCAGAGGGTGGACTCGCCAGTCACAGTGTGCGGCGACATCCATGGACAATTCTAT
GACCTCAAAGAGCTGTTCAGAGTAGGTGGCGACGTCCCTGAGACCAACTACCTCTTCATG
GGGGACTTTGTGGACCGTGGCTTCTATAGCGTCGAAACGTTCCTCCTGCTGCTGGCACTT
AAGGTTCGCTATCCTGATCGCATCACACTGATCCGGGGCAACCATGAGAGTCGCCAGATC
ACGCAGGTCTATGGCTTCTACGATGAGTGCCTGCGCAAGTACGGCTCGGTGACTGTGTGG
CGCTACTGCACTGAGATCTTTGACTACCTCAGCCTGTCAGCCATCATCGATGGCAAGATC
TTCTGCGTGCACGGGGGCCTCTCCCCCTCCATCCAGACCCTGGATCAGATTCGGACAATC
GACCGAAAGCAAGAGGTGCCTCATGATGGGCCCATGTGTGACCTCCTCTGGTCTGACCCA
GAAGACACCACAGGCTGGGGCGTGAGCCCCCGAGGAGCCGGCTACCTATTTGGCAGTGAC
GTGGTGGCCCAGTTCAACGCAGCCAATGACATTGACATGATCTGCCGTGCCCACCAACTG
GTGATGGAAGGTTACAAGTGGCACTTCAATGAGACGGTGCTCACTGTGTGGTCGGCACCC
AACTACTGCTACCGCTGTGGGAATGTGGCAGCCATCTTGGAGCTGGACGAGCATCTCCAG
AAAGATTTCATCATCTTTGAGGCTGCTCCCCAAGAGACACGGGGCATCCCCTCCAAGAAG
CCCGTGGCCGACTACTTCCTGTGA
Protein Properties
Number of Residues 307
Molecular Weight 35079.6
Theoretical pI 5.061
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Serine/threonine-protein phosphatase 4 catalytic subunit
MAEISDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFY
DLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQI
TQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTI
DRKQEVPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQL
VMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQETRGIPSKK
PVADYFL
GenBank ID Protein 4028575
UniProtKB/Swiss-Prot ID P60510
UniProtKB/Swiss-Prot Entry Name PP4C_HUMAN
PDB IDs Not Available
GenBank Gene ID AF097996
GeneCard ID PPP4C
GenAtlas ID PPP4C
HGNC ID HGNC:9319
References
General References Not Available