Identification
HMDB Protein ID CDBP00193
Secondary Accession Numbers Not Available
Name Heme oxygenase 1
Description Not Available
Synonyms
  1. HO-1
Gene Name HMOX1
Protein Type Enzyme
Biological Properties
General Function Involved in heme oxygenase (decyclizing) activity
Specific Function Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.
GO Classification
Biological Process
response to hydrogen peroxide
low-density lipoprotein particle clearance
positive regulation of smooth muscle cell proliferation
positive regulation of I-kappaB kinase/NF-kappaB cascade
small molecule metabolic process
regulation of sequence-specific DNA binding transcription factor activity
negative regulation of smooth muscle cell proliferation
negative regulation of sequence-specific DNA binding transcription factor activity
regulation of transcription from RNA polymerase II promoter in response to oxidative stress
regulation of blood pressure
regulation of angiogenesis
small GTPase mediated signal transduction
negative regulation of leukocyte migration
negative regulation of neuron apoptotic process
smooth muscle hyperplasia
cellular response to hypoxia
negative regulation of apoptotic process
wound healing involved in inflammatory response
cellular response to nutrient
positive regulation of vasodilation
cell death
excretion
response to nicotine
transmembrane transport
endothelial cell proliferation
erythrocyte homeostasis
heme catabolic process
response to estrogen stimulus
heme oxidation
cellular iron ion homeostasis
intrinsic apoptotic signaling pathway in response to DNA damage
intracellular protein kinase cascade
negative regulation of DNA binding
angiogenesis
negative regulation of mast cell cytokine production
positive regulation of angiogenesis
negative regulation of mast cell degranulation
protein homooligomerization
positive regulation of chemokine biosynthetic process
cellular response to cadmium ion
Cellular Component
endoplasmic reticulum membrane
cytosol
nucleolus
nucleus
caveola
extracellular space
Function
catalytic activity
heme oxygenase (decyclizing) activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity
Molecular Function
metal ion binding
signal transducer activity
heme binding
protein homodimerization activity
enzyme binding
heme oxygenase (decyclizing) activity
phospholipase D activity
Process
oxidation reduction
metabolic process
nitrogen compound metabolic process
heme metabolic process
heme oxidation
tetrapyrrole metabolic process
porphyrin metabolic process
Cellular Location
  1. Microsome
  2. Endoplasmic reticulum
Pathways
Gene Properties
Chromosome Location 22
Locus 22q13.1
SNPs HMOX1
Gene Sequence
>867 bp
ATGGAGCGTCCGCAACCCGACAGCATGCCCCAGGATTTGTCAGAGGCCCTGAAGGAGGCC
ACCAAGGAGGTGCACACCCAGGCAGAGAATGCTGAGTTCATGAGGAACTTTCAGAAGGGC
CAGGTGACCCGAGACGGCTTCAAGCTGGTGATGGCCTCCCTGTACCACATCTATGTGGCC
CTGGAGGAGGAGATTGAGCGCAACAAGGAGAGCCCAGTCTTCGCCCCTGTCTACTTCCCA
GAAGAGCTGCACCGCAAGGCTGCCCTGGAGCAGGACCTGGCCTTCTGGTACGGGCCCCGC
TGGCAGGAGGTCATCCCCTACACACCAGCCATGCAGCGCTATGTGAAGCGGCTCCACGAG
GTGGGGCGCACAGAGCCCGAGCTGCTGGTGGCCCACGCCTACACCCGCTACCTGGGTGAC
CTGTCTGGGGGCCAGGTGCTCAAAAAGATTGCCCAGAAAGCCCTGGACCTGCCCAGCTCT
GGCGAGGGCCTGGCCTTCTTCACCTTCCCCAACATTGCCAGTGCCACCAAGTTCAAGCAG
CTCTACCGCTCCCGCATGAACTCCCTGGAGATGACTCCCGCAGTCAGGCAGAGGGTGATA
GAAGAGGCCAAGACTGCGTTCCTGCTCAACATCCAGCTCTTTGAGGAGTTGCAGGAGCTG
CTGACCCATGACACCAAGGACCAGAGCCCCTCACGGGCACCAGGGCTTCGCCAGCGGGCC
AGCAACAAAGTGCAAGATTCTGCCCCCGTGGAGACTCCCAGAGGGAAGCCCCCACTCAAC
ACCCGCTCCCAGGCTCCGCTTCTCCGATGGGTCCTTACACTCAGCTTTCTGGTGGCGACA
GTTGCTGTAGGGCTTTATGCCATGTGA
Protein Properties
Number of Residues 288
Molecular Weight 32818.345
Theoretical pI 8.257
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Heme oxygenase 1
MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVA
LEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHE
VGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQ
LYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRA
SNKVQDSAPVETPRGKPPLNTRSQAPLLRWVLTLSFLVATVAVGLYAM
GenBank ID Protein 35173
UniProtKB/Swiss-Prot ID P09601
UniProtKB/Swiss-Prot Entry Name HMOX1_HUMAN
PDB IDs
GenBank Gene ID X06985
GeneCard ID HMOX1
GenAtlas ID HMOX1
HGNC ID HGNC:5013
References
General References Not Available