Cannabis Compound Database: Showing Protein Ferrochelatase, mitochondrial (CDBP00995)

Identification Biological properties Gene properties Protein properties External links References XML Show 4 compounds

Identification

HMDB Protein ID

CDBP00995

Secondary Accession Numbers

Not Available

Name

Ferrochelatase, mitochondrial

Description

Not Available

Synonyms

Heme synthase
Protoheme ferro-lyase

Gene Name

FECH

Protein Type

Enzyme

Biological Properties

General Function

Involved in ferrochelatase activity

Specific Function

Catalyzes the ferrous insertion into protoporphyrin IX.

GO Classification

Biological Process
protoporphyrinogen IX metabolic process
regulation of eIF2 alpha phosphorylation by heme
regulation of hemoglobin biosynthetic process
response to platinum ion
small molecule metabolic process
response to lead ion
response to arsenic-containing substance
cellular response to dexamethasone stimulus
heme biosynthetic process
response to methylmercury
response to light stimulus
response to insecticide
iron ion homeostasis
cholesterol metabolic process
response to drug
response to ethanol
generation of precursor metabolites and energy
erythrocyte differentiation
very-low-density lipoprotein particle assembly
detection of UV
Cellular Component
mitochondrial matrix
mitochondrial inner membrane
Function
catalytic activity
lyase activity
ferrochelatase activity
Molecular Function
ferrochelatase activity
ferrous iron binding
2 iron, 2 sulfur cluster binding
iron-responsive element binding
heme binding
Process
metabolic process
nitrogen compound metabolic process
tetrapyrrole metabolic process
porphyrin metabolic process
heme biosynthetic process
porphyrin biosynthetic process

Cellular Location

Peripheral membrane protein
Mitochondrion inner membrane
Matrix side

Pathways

Name	SMPDB/Pathwhiz	KEGG
protoheme biosynthesis	Not Available	Not Available
Porphyrin and chlorophyll metabolism	Not Available
Porphyrin Metabolism
Acute Intermittent Porphyria		Not Available
Porphyria Variegata (PV)		Not Available

Gene Properties

Chromosome Location

Locus

18q21.3

SNPs

FECH

Gene Sequence

>1272 bp
ATGCGTTCACTCGGCGCAAACATGGCTGCGGCCCTGCGCGCCGCGGGCGTCCTGCTCCGC
GATCCGCTGGCATCCAGCAGCTGGAGGGTCTGTCAGCCATGGAGGTGGAAGTCAGGTGCA
GCTGCAGCGGCCGTCACCACAGAAACAGCCCAGCATGCCCAGGGTGCAAAACCTCAAGTT
CAACCGCAGAAGAGGAAGCCGAAAACTGGAATATTAATGCTAAACATGGGAGGCCCTGAA
ACTCTTGGAGATGTTCACGACTTCCTTCTGAGACTCTTCTTGGACCGAGACCTCATGACA
CTTCCTATTCAGAATAAGCTGGCACCATTCATCGCCAAACGCCGAACCCCCAAGATTCAA
GAGCAGTACCGCAGGATTGGAGGCGGATCCCCCATCAAGATATGGACTTCCAAGCAGGGA
GAGGGCATGGTGAAGCTGCTGGATGAATTGTCCCCCAACACAGCCCCTCACAAATACTAT
ATTGGATTTCGGTACGTCCATCCTTTAACAGAAGAAGCAATTGAAGAGATGGAGAGAGAT
GGCCTAGAAAGGGCTATTGCTTTCACACAGTATCCACAGTACAGCTGCTCCACCACAGGC
AGCAGCTTAAATGCCATTTACAGATACTATAATCAAGTGGGACGGAAGCCCACGATGAAG
TGGAGCACTATTGACAGGTGGCCCACACATCACCTCCTCATCCAGTGCTTTGCAGATCAT
ATTCTAAAGGAACTGGACCATTTTCCACTTGAGAAGAGAAGCGAGGTGGTCATTCTGTTT
TCTGCTCACTCACTGCCCATGTCTGTGGTCAACAGAGGCGACCCATATCCTCAGGAGGTA
AGCGCCACTGTCCAAAAAGTCATGGAAAGGCTGGAGTACTGCAACCCCTACCGACTGGTG
TGGCAATCCAAGGTTGGTCCAATGCCCTGGTTGGGTCCTCAAACAGACGAATCTATCAAA
GGGCTTTGTGAGAGGGGGAGGAAGAATATCCTCTTGGTTCCGATAGCATTTACCAGTGAC
CATATTGAAACGCTGTATGAGCTGGACATCGAGTACTCTCAAGTTTTAGCCAAGGAGTGT
GGAGTTGAAAACATCAGAAGAGCTGAGTCTCTTAATGGAAATCCATTGTTCTCTAAGGCC
CTGGCCGACTTGGTGCATTCACACATCCAGTCAAACGAGCTGTGTTCCAAGCAGCTGACC
CTGAGCTGTCCGCTCTGTGTCAATCCTGTCTGCAGGGAGACTAAATCCTTCTTCACCAGC
CAGCAGCTGTGA

Protein Properties

Number of Residues

423

Molecular Weight

47861.77

Theoretical pI

8.728

Pfam Domain Function

Ferrochelatase (PF00762 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Ferrochelatase, mitochondrial
MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQV
QPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQ
EQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERD
GLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADH
ILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLV
WQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKEC
GVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS
QQL

External Links

GenBank ID Protein

60499021

UniProtKB/Swiss-Prot ID

P22830

UniProtKB/Swiss-Prot Entry Name

HEMH_HUMAN

PDB IDs