| Identification |
|---|
| HMDB Protein ID
| CDBP03173 |
| Secondary Accession Numbers
| Not Available |
| Name
| Peroxidasin homolog |
| Description
| Not Available |
| Synonyms
|
- Melanoma-associated antigen MG50
- Vascular peroxidase 1
- p53-responsive gene 2 protein
|
| Gene Name
| PXDN |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in peroxidase activity |
| Specific Function
| Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation.
|
| GO Classification
|
| Biological Process |
| extracellular matrix organization |
| immune response |
| hydrogen peroxide catabolic process |
| Cellular Component |
| endoplasmic reticulum |
| proteinaceous extracellular matrix |
| extracellular space |
| extracellular matrix |
| Function |
| iron ion binding |
| protein binding |
| antioxidant activity |
| heme binding |
| peroxidase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| Molecular Function |
| metal ion binding |
| extracellular matrix structural constituent |
| heme binding |
| peroxidase activity |
| interleukin-1 receptor antagonist activity |
| Process |
| response to stimulus |
| response to stress |
| response to oxidative stress |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Secreted
- extracellular space
- extracellular matrix
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| 2p25 |
| SNPs
| PXDN |
| Gene Sequence
|
>4440 bp
ATGGCCAAGCGCTCCAGGGGCCCCGGGCGCCGCTGCCTGTTGGCGCTCGTGCTGTTCTGC
GCCTGGGGGACGCTGGCCGTGGTGGCCCAGAAGCCGGGCGCAGGGTGTCCGAGCCGCTGC
CTGTGCTTCCGCACCACCGTGCGCTGCATGCATCTGCTGCTGGAGGCCGTGCCCGCCGTG
GCGCCGCAGACCTCCATCCTAGATCTTCGCTTTAACAGAATCAGAGAGATCCAACCTGGG
GCATTCAGGCGGCTGAGGAACTTGAACACATTGCTTCTCAATAATAATCAGATCAAGAGG
ATACCTAGTGGAGCATTTGAAGACTTGGAAAATTTAAAATATCTCTATCTGTACAAGAAT
GAGATCCAGTCAATTGACAGGCAAGCATTTAAGGGACTTGCCTCTCTAGAGCAACTATAC
CTGCACTTTAATCAGATAGAAACTTTGGACCCAGATTCGTTCCAGCATCTCCCGAAGCTC
GAGAGGCTATTTTTGCATAACAACCGGATTACACATTTAGTTCCAGGGACATTTAATCAC
TTGGAATCTATGAAGAGATTGCGACTGGACTCAAACACACTTCACTGCGACTGTGAAATC
CTGTGGTTGGCGGATTTGCTGAAAACCTACGCGGAGTCGGGGAACGCGCAGGCAGCGGCC
ATCTGTGAATATCCCAGACGCATCCAGGGACGCTCAGTGGCAACCATCACCCCGGAAGAG
CTGAACTGTGAAAGGCCCCGGATCACCTCCGAGCCCCAGGACGCAGATGTGACCTCGGGG
AACACCGTGTACTTCACCTGCAGAGCCGAAGGCAACCCCAAGCCTGAGATCATCTGGCTG
CGAAACAATAATGAGCTGAGCATGAAGACAGATTCCCGCCTAAACTTGCTGGACGATGGG
ACCCTGATGATCCAGAACACACAGGAGACAGACCAGGGTATCTACCAGTGCATGGCAAAG
AACGTGGCCGGAGAGGTGAAGACGCAAGAGGTGACCCTCAGGTACTTCGGGTCTCCAGCT
CGACCCACTTTTGTAATCCAGCCACAGAATACAGAGGTGCTGGTTGGGGAGAGCGTCACG
CTGGAGTGCAGCGCCACAGGCCACCCCCCGCCGCGGATCTCCTGGACGAGAGGTGACCGC
ACACCCTTGCCAGTTGACCCGCGGGTGAACATCACGCCTTCTGGCGGGCTTTACATACAG
AACGTCGTACAGGGGGACAGCGGAGAGTATGCGTGCTCTGCGACCAACAACATTGACAGC
GTCCATGCCACCGCTTTCATCATCGTCCAGGCTCTTCCTCAGTTCACTGTGACGCCTCAG
GACAGAGTCGTTATTGAGGGCCAGACCGTGGATTTCCAGTGTGAAGCCAAGGGCAACCCG
CCGCCCGTCATCGCCTGGACCAAGGGAGGGAGCCAGCTCTCCGTGGACCGGCGGCACCTG
GTCCTGTCATCGGGAACACTTAGAATCTCTGGTGTTGCCCTCCACGACCAGGGCCAGTAC
GAATGCCAGGCTGTCAACATCATCGGCTCCCAGAAGGTCGTGGCCCACCTGACTGTGCAG
CCCAGAGTCACCCCAGTGTTTGCCAGCATTCCCAGCGACACAACAGTGGAGGTGGGCGCC
AATGTGCAGCTCCCGTGCAGCTCCCAGGGCGAGCCCGAGCCAGCCATCACCTGGAACAAG
GATGGGGTTCAGGTGACAGAAAGTGGAAAATTTCACATCAGCCCTGAAGGATTCTTGACC
ATCAATGACGTTGGCCCTGCAGACGCAGGTCGCTATGAGTGTGTGGCCCGGAACACCATT
GGGTCGGCCTCGGTGAGCATGGTGCTCAGTGTGAATGTTCCTGACGTCAGTCGAAATGGA
GATCCGTTTGTAGCTACCTCCATCGTGGAAGCGATTGCGACTGTTGACAGAGCTATAAAC
TCAACCCGAACACATTTGTTTGACAGCCGTCCTCGTTCTCCAAATGATTTGCTGGCCTTG
TTCCGGTATCCGAGGGATCCTTACACAGTTGAACAGGCACGGGCGGGAGAAATCTTTGAA
CGGACATTGCAGCTCATTCAGGAGCATGTACAGCATGGCTTGATGGTCGACCTCAACGGA
ACAAGTTACCACTACAACGACCTGGTGTCTCCACAGTACCTGAACCTCATCGCAAACCTG
TCGGGCTGTACCGCCCACCGGCGCGTGAACAACTGCTCGGACATGTGCTTCCACCAGAAG
TACCGGACGCACGACGGCACCTGTAACAACCTGCAGCACCCCATGTGGGGCGCCTCGCTG
ACCGCCTTCGAGCGCCTGCTGAAATCCGTGTACGAGAATGGCTTCAACACCCCTCGGGGC
ATCAACCCCCACCGACTGTACAACGGGCACGCCCTTCCCATGCCGCGCCTGGTGTCCACC
ACCCTGATCGGGACGGAGACCGTCACACCCGACGAGCAGTTCACCCACATGCTGATGCAG
TGGGGCCAGTTCCTGGACCACGACCTCGACTCCACGGTGGTGGCCCTGAGCCAGGCACGC
TTCTCCGACGGACAGCACTGCAGCAACGTGTGCAGCAACGACCCCCCCTGCTTCTCTGTC
ATGATCCCCCCCAATGACTCCCGGGCCAGGAGCGGGGCCCGCTGCATGTTCTTCGTGCGC
TCCAGCCCTGTGTGCGGCAGCGGCATGACTTCGCTGCTCATGAACTCCGTGTACCCGCGG
GAGCAGATCAACCAGCTCACCTCCTACATAGACGCATCCAACGTGTACGGGAGCACGGAG
CATGAGGCCCGCAGCATCCGCGACCTGGCCAGCCACCGCGGCCTGCTGCGGCAGGGCATC
GTGCAGCGGTCCGGGAAGCCGCTGCTCCCCTTCGCCACCGGGCCGCCCACGGAGTGCATG
CGGGACGAGAACGAGAGCCCCATCCCCTGCTTCCTGGCCGGGGACCACCGCGCCAACGAG
CAGCTGGGCCTGACCAGCATGCACACGCTGTGGTTCCGCGAGCACAACCGCATTGCCACG
GAGCTGCTCAAGCTGAACCCGCACTGGGACGGCGACACCATCTACTATGAGACCAGGAAG
ATCGTGGGTGCGGAGATCCAGCACATCACCTACCAGCACTGGCTCCCGAAGATCCTGGGG
GAGGTGGGCATGAGGACGCTGGGAGAGTACCACGGCTACGACCCCGGCATCAATGCTGGC
ATCTTCAACGCCTTCGCCACCGCGGCCTTCAGGTTTGGCCACACGCTTGTCAACCCACTG
CTTTACCGGCTGGACGAGAACTTCCAGCCCATTGCACAAGATCACCTCCCCCTTCACAAA
GCTTTCTTCTCTCCCTTCCGGATTGTGAATGAGGGCGGCATCGATCCGCTTCTCAGGGGG
CTGTTCGGGGTGGCGGGGAAAATGCGTGTGCCCTCGCAGCTGCTGAACACGGAGCTCACG
GAGCGGCTGTTCTCCATGGCACACACGGTGGCTCTGGACCTGGCGGCCATCAACATCCAG
CGGGGCCGGGACCACGGGATCCCACCCTACCACGACTACAGGGTCTACTGCAATCTATCG
GCGGCACACACGTTCGAGGACCTGAAAAATGAGATTAAAAACCCTGAGATCCGGGAGAAA
CTGAAAAGGTTGTATGGCTCGACACTCAACATCGACCTGTTTCCGGCGCTCGTGGTGGAG
GACCTGGTGCCTGGCAGCCGGCTGGGCCCCACCCTGATGTGTCTTCTCAGCACACAGTTC
AAGCGCCTGCGAGATGGGGACAGGTTGTGGTATGAGAACCCTGGGGTGTTCTCCCCGGCC
CAGCTGACTCAGATCAAGCAGACGTCGCTGGCCAGGATCCTATGCGACAACGCGGACAAC
ATCACCCGGGTGCAGAGCGACGTGTTCAGGGTGGCGGAGTTCCCTCACGGCTACGGCAGC
TGTGACGAGATCCCCAGGGTAGACCTCCGGGTGTGGCAGGACTGCTGTGAAGACTGTAGG
ACCAGGGGGCAGTTCAATGCCTTTTCCTATCATTTCCGAGGCAGACGGTCTCTTGAGTTC
AGCTACCAGGAGGACAAGCCGACCAAGAAAACAAGACCACGGAAAATACCCAGTGTTGGG
AGACAGGGGGAACATCTCAGCAACAGCACCTCAGCCTTCAGCACACGCTCAGATGCATCT
GGGACAAATGACTTCAGAGAGTTTGTTCTGGAAATGCAGAAGACCATCACAGACCTCAGA
ACACAGATAAAGAAACTTGAATCACGGCTCAGTACCACAGAGTGCGTGGATGCCGGGGGC
GAATCTCACGCCAACAACACCAAGTGGAAAAAAGATGCATGCACCATTTGTGAATGCAAA
GACGGGCAGGTCACCTGCTTCGTGGAAGCTTGCCCCCCTGCCACCTGTGCTGTCCCCGTG
AACATCCCAGGGGCCTGCTGTCCAGTCTGCTTACAGAAGAGGGCGGAGGAAAAGCCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1479 |
| Molecular Weight
| 165273.15 |
| Theoretical pI
| 7.173 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Peroxidasin homolog
MAKRSRGPGRRCLLALVLFCAWGTLAVVAQKPGAGCPSRCLCFRTTVRCMHLLLEAVPAV
APQTSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKN
EIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNH
LESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEE
LNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDG
TLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVT
LECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDS
VHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHL
VLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGA
NVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTI
GSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRAINSTRTHLFDSRPRSPNDLLAL
FRYPRDPYTVEQARAGEIFERTLQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLNLIANL
SGCTAHRRVNNCSDMCFHQKYRTHDGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRG
INPHRLYNGHALPMPRLVSTTLIGTETVTPDEQFTHMLMQWGQFLDHDLDSTVVALSQAR
FSDGQHCSNVCSNDPPCFSVMIPPNDSRARSGARCMFFVRSSPVCGSGMTSLLMNSVYPR
EQINQLTSYIDASNVYGSTEHEARSIRDLASHRGLLRQGIVQRSGKPLLPFATGPPTECM
RDENESPIPCFLAGDHRANEQLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRK
IVGAEIQHITYQHWLPKILGEVGMRTLGEYHGYDPGINAGIFNAFATAAFRFGHTLVNPL
LYRLDENFQPIAQDHLPLHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLNTELT
ERLFSMAHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAHTFEDLKNEIKNPEIREK
LKRLYGSTLNIDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYENPGVFSPA
QLTQIKQTSLARILCDNADNITRVQSDVFRVAEFPHGYGSCDEIPRVDLRVWQDCCEDCR
TRGQFNAFSYHFRGRRSLEFSYQEDKPTKKTRPRKIPSVGRQGEHLSNSTSAFSTRSDAS
GTNDFREFVLEMQKTITDLRTQIKKLESRLSTTECVDAGGESHANNTKWKKDACTICECK
DGQVTCFVEACPPATCAVPVNIPGACCPVCLQKRAEEKP
|
| External Links |
|---|
| GenBank ID Protein
| 109150416 |
| UniProtKB/Swiss-Prot ID
| Q92626 |
| UniProtKB/Swiss-Prot Entry Name
| PXDN_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_012293.1 |
| GeneCard ID
| PXDN |
| GenAtlas ID
| PXDN |
| HGNC ID
| HGNC:14966 |
| References |
|---|
| General References
| Not Available |