| Identification |
|---|
| HMDB Protein ID
| CDBP00146 |
| Secondary Accession Numbers
| Not Available |
| Name
| Heme oxygenase 2 |
| Description
| Not Available |
| Synonyms
|
- HO-2
|
| Gene Name
| HMOX2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in heme oxygenase (decyclizing) activity |
| Specific Function
| Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.
|
| GO Classification
|
| Biological Process |
| heme catabolic process |
| cellular iron ion homeostasis |
| heme oxidation |
| response to hypoxia |
| transmembrane transport |
| small molecule metabolic process |
| response to oxidative stress |
| Cellular Component |
| endoplasmic reticulum membrane |
| plasma membrane |
| Function |
| catalytic activity |
| heme oxygenase (decyclizing) activity |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| oxidoreductase activity |
| Molecular Function |
| metal ion binding |
| heme oxygenase (decyclizing) activity |
| Process |
| heme oxidation |
| tetrapyrrole metabolic process |
| porphyrin metabolic process |
| oxidation reduction |
| metabolic process |
| nitrogen compound metabolic process |
| heme metabolic process |
|
| Cellular Location
|
- Microsome
- Endoplasmic reticulum
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Porphyrin and chlorophyll metabolism | Not Available |  | | Mineral absorption | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| 16p13.3 |
| SNPs
| HMOX2 |
| Gene Sequence
|
>951 bp
ATGTCAGCGGAAGTGGAAACCTCAGAGGGGGTAGACGAGTCAGAAAAAAAGAACTCTGGG
GCCCTAGAAAAGGAGAACCAAATGAGAATGGCTGACCTCTCGGAGCTCCTGAAGGAAGGG
ACCAAGGAAGCACACGACCGGGCAGAAAACACCCAGTTTGTCAAGGACTTCTTGAAAGGC
AACATTAAGAAGGAGCTGTTTAAGCTGGCCACCACGGCACTTTACTTCACATACTCAGCC
CTCGAGGAGGAAATGGAGCGCAACAAGGACCATCCAGCCTTTGCCCCTTTGTACTTCCCC
ATGGAGCTGCACCGGAAGGAGGCGCTGACCAAGGACATGGAGTATTTCTTTGGTGAAAAC
TGGGAGGAGCAGGTGCAGTGCCCCAAGGCTGCCCAGAAGTACGTGGAGCGGATCCACTAC
ATAGGGCAGAACGAGCCGGAGCTACTGGTGGCCCATGCATACACCCGCTACATGGGGGAT
CTCTCGGGGGGCCAGGTGCTGAAGAAGGTGGCCCAGCGAGCACTGAAACTCCCCAGCACA
GGGGAAGGGACCCAGTTCTACCTGTTTGAGAATGTGGACAATGCCCAGCAGTTCAAGCAG
CTCTACCGGGCCAGGATGAACGCCCTGGACCTGAACATGAAGACCAAAGAGAGGATCGTG
GAGGAGGCCAACAAGGCTTTTGAGTATAACATGCAGATATTCAATGAACTGGACCAGGCC
GGCTCCACACTGGCCAGAGAGACCTTGGAGGATGGGTTCCCTGTACACGATGGGAAAGGA
GACATGCGTAAATGCCCTTTCTACGCTGCTGAACAAGACAAAGGTGCCCTGGAGGGCAGC
AGCTGTCCCTTCCGAACAGCTATGGCTGTGCTGAGGAAGCCCAGCCTCCAGTTCATCCTG
GCCGCTGGTGTGGCCCTAGCTGCTGGACTCTTGGCCTGGTACTACATGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 316 |
| Molecular Weight
| 36032.615 |
| Theoretical pI
| 5.41 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Heme oxygenase 2
MSAEVETSEGVDESEKKNSGALEKENQMRMADLSELLKEGTKEAHDRAENTQFVKDFLKG
NIKKELFKLATTALYFTYSALEEEMERNKDHPAFAPLYFPMELHRKEALTKDMEYFFGEN
WEEQVQCPKAAQKYVERIHYIGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPST
GEGTQFYLFENVDNAQQFKQLYRARMNALDLNMKTKERIVEEANKAFEYNMQIFNELDQA
GSTLARETLEDGFPVHDGKGDMRKCPFYAAEQDKGALEGSSCPFRTAMAVLRKPSLQFIL
AAGVALAAGLLAWYYM
|
| External Links |
|---|
| GenBank ID Protein
| 187761307 |
| UniProtKB/Swiss-Prot ID
| P30519 |
| UniProtKB/Swiss-Prot Entry Name
| HMOX2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_001127204.1 |
| GeneCard ID
| HMOX2 |
| GenAtlas ID
| HMOX2 |
| HGNC ID
| HGNC:5014 |
| References |
|---|
| General References
| Not Available |