| Identification |
|---|
| HMDB Protein ID
| CDBP03894 |
| Secondary Accession Numbers
| Not Available |
| Name
| Serine/threonine-protein phosphatase PP1-alpha catalytic subunit |
| Description
| Not Available |
| Synonyms
|
- PP-1A
|
| Gene Name
| PPP1CA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity |
| Specific Function
| Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| cell cycle |
| cell division |
| branching morphogenesis of a tube |
| glycogen metabolic process |
| triglyceride catabolic process |
| negative regulation of transforming growth factor beta receptor signaling pathway |
| lung development |
| transforming growth factor beta receptor signaling pathway |
| regulation of glycogen biosynthetic process |
| regulation of glycogen catabolic process |
| protein dephosphorylation |
| Cellular Component |
| dendritic spine |
| protein phosphatase type 1 complex |
| PTW/PP1 phosphatase complex |
| glycogen granule |
| MLL5-L complex |
| cytosol |
| nucleolus |
| perikaryon |
| Function |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| protein serine/threonine phosphatase activity |
| metal ion binding |
| ribonucleoprotein complex binding |
|
| Cellular Location
|
- Cytoplasmic
- Nucleus
- Nucleus
- Nucleus
- Cytoplasm
- nucleolus
- nucleoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | mRNA surveillance pathway | Not Available |  | | Oocyte meiosis | Not Available |  | | Vascular smooth muscle contraction | Not Available |  | | Hippo signaling pathway | Not Available |  | | Focal adhesion | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11q13 |
| SNPs
| PPP1CA |
| Gene Sequence
|
>993 bp
ATGTCCGACAGCGAGAAGCTCAACCTGGACTCGATCATCGGGCGCCTGCTGGAAGTGCAG
GGCTCGCGGCCTGGCAAGAATGTACAGCTGACAGAGAACGAGATCCGCGGTCTGTGCCTG
AAATCCCGGGAGATTTTTCTGAGCCAGCCCATTCTTCTGGAGCTGGAGGCACCCCTCAAG
ATCTGCGGTGACATACACGGCCAGTACTACGACCTTCTGCGACTATTTGAGTATGGCGGT
TTCCCTCCCGAGAGCAACTACCTCTTTCTGGGGGACTATGTGGACAGGGGCAAGCAGTCC
TTGGAGACCATCTGCCTGCTGCTGGCCTATAAGATCAAGTACCCCGAGAACTTCTTCCTG
CTCCGTGGGAACCACGAGTGTGCCAGCATCAACCGCATCTATGGTTTCTACGATGAGTGC
AAGAGACGCTACAACATCAAACTGTGGAAAACCTTCACTGACTGCTTCAACTGCCTGCCC
ATCGCGGCCATAGTGGACGAAAAGATCTTCTGCTGCCACGGAGGCCTGTCCCCGGACCTG
CAGTCTATGGAGCAGATTCGGCGGATCATGCGGCCCACAGATGTGCCTGACCAGGGCCTG
CTGTGTGACCTGCTGTGGTCTGACCCTGACAAGGACGTGCAGGGCTGGGGCGAGAACGAC
CGTGGCGTCTCTTTTACCTTTGGAGCCGAGGTGGTGGCCAAGTTCCTCCACAAGCACGAC
TTGGACCTCATCTGCCGAGCACACCAGGTGGTAGAAGACGGCTACGAGTTCTTTGCCAAG
CGGCAGCTGGTGACACTTTTCTCAGCTCCCAACTACTGTGGCGAGTTTGACAATGCTGGC
GCCATGATGAGTGTGGACGAGACCCTCATGTGCTCTTTCCAGATCCTCAAGCCCGCCGAC
AAGAACAAGGGGAAGTACGGGCAGTTCAGTGGCCTGAACCCTGGAGGCCGACCCATCACC
CCACCCCGCAATTCCGCCAAAGCCAAGAAATAG
|
| Protein Properties |
|---|
| Number of Residues
| 330 |
| Molecular Weight
| 38630.99 |
| Theoretical pI
| 6.629 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLK
ICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFL
LRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDL
QSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHD
LDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAD
KNKGKYGQFSGLNPGGRPITPPRNSAKAKK
|
| External Links |
|---|
| GenBank ID Protein
| 35451 |
| UniProtKB/Swiss-Prot ID
| P62136 |
| UniProtKB/Swiss-Prot Entry Name
| PP1A_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X70848 |
| GeneCard ID
| PPP1CA |
| GenAtlas ID
| PPP1CA |
| HGNC ID
| HGNC:9281 |
| References |
|---|
| General References
| Not Available |