Identification
HMDB Protein ID CDBP00913
Secondary Accession Numbers Not Available
Name Prostaglandin G/H synthase 2
Description Not Available
Synonyms
  1. COX-2
  2. Cyclooxygenase-2
  3. PGH synthase 2
  4. PGHS-2
  5. PHS II
  6. Prostaglandin H2 synthase 2
  7. Prostaglandin-endoperoxide synthase 2
Gene Name PTGS2
Protein Type Enzyme
Biological Properties
General Function Involved in peroxidase activity
Specific Function Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.
GO Classification
Biological Process
negative regulation of synaptic transmission, dopaminergic
response to estradiol stimulus
inflammatory response
response to drug
positive regulation of brown fat cell differentiation
cellular response to hypoxia
brown fat cell differentiation
positive regulation of cell migration involved in sprouting angiogenesis
positive regulation of smooth muscle contraction
positive regulation of nitric oxide biosynthetic process
positive regulation of fibroblast growth factor production
positive regulation of smooth muscle cell proliferation
positive regulation of fever generation
positive regulation of platelet-derived growth factor production
response to manganese ion
positive regulation of prostaglandin biosynthetic process
positive regulation of synaptic plasticity
regulation of cell cycle
memory
positive regulation of synaptic transmission, glutamatergic
response to glucocorticoid stimulus
positive regulation of transforming growth factor beta production
bone mineralization
positive regulation of apoptotic process
decidualization
positive regulation of vasoconstriction
xenobiotic metabolic process
response to fructose stimulus
response to vitamin D
response to organic nitrogen
positive regulation vascular endothelial growth factor production
negative regulation of calcium ion transport
response to lipopolysaccharide
cyclooxygenase pathway
regulation of blood pressure
cellular component movement
anagen
negative regulation of cell proliferation
response to oxidative stress
embryo implantation
response to cytokine stimulus
ovulation
Cellular Component
endoplasmic reticulum membrane
endoplasmic reticulum lumen
nucleus
caveola
neuron projection
protein complex
Function
binding
transition metal ion binding
iron ion binding
peroxidase activity
ion binding
cation binding
antioxidant activity
metal ion binding
heme binding
Molecular Function
prostaglandin-endoperoxide synthase activity
metal ion binding
lipid binding
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
heme binding
peroxidase activity
Process
response to stimulus
response to stress
response to oxidative stress
metabolic process
oxidation reduction
Cellular Location
  1. Peripheral membrane protein
  2. Peripheral membrane protein
  3. Endoplasmic reticulum membrane
  4. Microsome membrane
Pathways
Gene Properties
Chromosome Location 1
Locus 1q25.2-q25.3
SNPs PTGS2
Gene Sequence
>1815 bp
ATGCTCGCCCGCGCCCTGCTGCTGTGCGCGGTCCTGGCGCTCAGCCATACAGCAAATCCT
TGCTGTTCCCACCCATGTCAAAACCGAGGTGTATGTATGAGTGTGGGATTTGACCAGTAT
AAGTGCGATTGTACCCGGACAGGATTCTATGGAGAAAACTGCTCAACACCGGAATTTTTG
ACAAGAATAAAATTATTTCTGAAACCCACTCCAAACACAGTGCACTACATACTTACCCAC
TTCAAGGGATTTTGGAACGTTGTGAATAACATTCCCTTCCTTCGAAATGCAATTATGAGT
TATGTGTTGACATCCAGATCACATTTGATTGACAGTCCACCAACTTACAATGCTGACTAT
GGCTACAAAAGCTGGGAAGCCTTCTCTAACCTCTCCTATTATACTAGAGCCCTTCCTCCT
GTGCCTGATGATTGCCCGACTCCCTTGGGTGTCAAAGGTAAAAAGCAGCTTCCTGATTCA
AATGAGATTGTGGAAAAATTGCTTCTAAGAAGAAAGTTCATCCCTGATCCCCAGGGCTCA
AACATGATGTTTGCATTCTTTGCCCAGCACTTCACGCATCAGTTTTTCAAGACAGATCAT
AAGCGAGGGCCAGCTTTCACCAACGGGCTGGGCCATGGGGTGGACTTAAATCATATTTAC
GGTGAAACTCTGGCTAGACAGCGTAAACTGCGCCTTTTCAAGGATGGAAAAATGAAATAT
CAGATAATTGATGGAGAGATGTATCCTCCCACAGTCAAAGATACTCAGGCAGAGATGATC
TACCCTCCTCAAGTCCCTGAGCATCTACGGTTTGCTGTGGGGCAGGAGGTCTTTGGTCTG
GTGCCTGGTCTGATGATGTATGCCACAATCTGGCTGCGGGAACACAACAGAGTATGCGAT
GTGCTTAAACAGGAGCATCCTGAATGGGGTGATGAGCAGTTGTTCCAGACAAGCAGGCTA
ATACTGATAGGAGAGACTATTAAGATTGTGATTGAAGATTATGTGCAACACTTGAGTGGC
TATCACTTCAAACTGAAATTTGACCCAGAACTACTTTTCAACAAACAATTCCAGTACCAA
AATCGTATTGCTGCTGAATTTAACACCCTCTATCACTGGCATCCCCTTCTGCCTGACACC
TTTCAAATTCATGACCAGAAATACAACTATCAACAGTTTATCTACAACAACTCTATATTG
CTGGAACATGGAATTACCCAGTTTGTTGAATCATTCACCAGGCAAATTGCTGGCAGGGTT
GCTGGTGGTAGGAATGTTCCACCCGCAGTACAGAAAGTATCACAGGCTTCCATTGACCAG
AGCAGGCAGATGAAATACCAGTCTTTTAATGAGTACCGCAAACGCTTTATGCTGAAGCCC
TATGAATCATTTGAAGAACTTACAGGAGAAAAGGAAATGTCTGCAGAGTTGGAAGCACTC
TATGGTGACATCGATGCTGTGGAGCTGTATCCTGCCCTTCTGGTAGAAAAGCCTCGGCCA
GATGCCATCTTTGGTGAAACCATGGTAGAAGTTGGAGCACCATTCTCCTTGAAAGGACTT
ATGGGTAATGTTATATGTTCTCCTGCCTACTGGAAGCCAAGCACTTTTGGTGGAGAAGTG
GGTTTTCAAATCATCAACACTGCCTCAATTCAGTCTCTCATCTGCAATAACGTGAAGGGC
TGTCCCTTTACTTCATTCAGTGTTCCAGATCCAGAGCTCATTAAAACAGTCACCATCAAT
GCAAGTTCTTCCCGCTCCGGACTAGATGATATCAATCCCACAGTACTACTAAAAGAACGT
TCGACTGAACTGTAG
Protein Properties
Number of Residues 604
Molecular Weight 68995.625
Theoretical pI 7.383
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Prostaglandin G/H synthase 2
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADY
GYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKY
QIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCD
VLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQ
NRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRV
AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEAL
YGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEV
GFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKER
STEL
GenBank ID Protein 158257766
UniProtKB/Swiss-Prot ID P35354
UniProtKB/Swiss-Prot Entry Name PGH2_HUMAN
PDB IDs
GenBank Gene ID AK292167
GeneCard ID PTGS2
GenAtlas ID PTGS2
HGNC ID HGNC:9605
References
General References Not Available