Cannabis Compound Database: Showing Protein Serine/threonine-protein phosphatase with EF-hands 2 (CDBP03166)

Identification Biological properties Gene properties Protein properties External links References XML Show 4 compounds

Identification

HMDB Protein ID

CDBP03166

Secondary Accession Numbers

Not Available

Name

Serine/threonine-protein phosphatase with EF-hands 2

Description

Not Available

Synonyms

PPEF-2

Gene Name

PPEF2

Protein Type

Enzyme

Biological Properties

General Function

Involved in calcium ion binding

Specific Function

May play a role in phototransduction. May dephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic currents, energy production or synaptic transmission.

GO Classification

Biological Process
regulation of JUN kinase activity
negative regulation of peptidyl-threonine phosphorylation
visual perception
detection of stimulus involved in sensory perception
negative regulation of MAPK cascade
protein dephosphorylation
Cellular Component
cytoplasm
photoreceptor inner segment
photoreceptor outer segment
Function
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
transition metal ion binding
phosphoric ester hydrolase activity
phosphatase activity
protein serine/threonine phosphatase activity
iron ion binding
calcium ion binding
phosphoprotein phosphatase activity
manganese ion binding
ion binding
cation binding
metal ion binding
Molecular Function
protein serine/threonine phosphatase activity
manganese ion binding
iron ion binding
calcium ion binding
Hsp70 protein binding
Hsp90 protein binding
Process
response to stimulus
detection of stimulus
detection of stimulus involved in sensory perception

Cellular Location

Cytoplasm (Probable)
Cell projection
cilium
photoreceptor outer segment
Photoreceptor inner segment

Pathways

Not Available

Gene Properties

Chromosome Location

Locus

4q21.1

SNPs

PPEF2

Gene Sequence

>2262 bp
ATGGGAAGCGGCACCTCCACCCAACATCATTTTGCTTTCCAGAATGCAGAGAGAGCCTTC
AAGGCAGCAGCCCTGATCCAGAGATGGTACCGGCGCTACGTGGCCCGCCTGGAGATGAGG
CGGCGTTGCACCTGGAGCATCTTCCAGTCTATAGAATATGCTGGGCAGCAAGACCAAGTC
AAGCTCCATGACTTCTTCAGCTATCTCATGGATCACTTCATCCCCAGCAGCCACAACGAC
AGGGACTTCCTGACCCGCATATTCACTGAGGACAGATTCGCCCAGGACTCCGAGATGAAG
AAATGCAGTGACTATGAATCCATAGAGGTACCCGACAGTTACACGGGGCCACGCCTCTCC
TTCCCACTCCTGCCTGACCATGCAACTGCCCTGGTAGAAGCATTCAGACTGAAACAACAG
CTCCATGCTCGCTACGTCTTGAACCTTTTGTATGAAACCAAGAAACATCTGGTACAGCTG
CCAAACATCAACCGGGTCTCAACCTGTTACAGTGAGGAGATCACAGTGTGTGGAGACTTA
CATGGCCAATTGGATGACTTAATCTTTATATTTTATAAGAATGGCCTCCCGTCGCCAGAA
CGGTCATATGTGTTCAACGGTGACTTTGTGGATCGAGGCAAGGATTCAGTAGAGATCCTG
ATGATTCTTTTTGCCTTCATGCTGGTTTACCCCAAAGAGTTCCATCTTAACAGAGGAAAC
CATGAGGACCATATGGTGAACTTACGATATGGCTTCACCAAGGAAGTGATGAATAAATAC
AAGGTACACGGGAAGGAAATACTAAGAACCCTGCAAGATGTTTTCTGTTGGCTTCCACTG
GCCACTCTGATAGATGAGAAAGTTCTAATTCTTCATGGTGGGGTGTCAGACATAACTGAT
CTGGAGCTTTTGGACAAAATAGAGAGGAGCAAGATAGTTTCCACCATGAGGTGCAAAACG
AGACAGAAGAGTGAGAAGCAGATGGAGGAGAAGAGAAGAGCCAACCAGAAGAGCTCTGCA
CAGGGACCCATCCCATGGTTTCTCCCCGAAAGCCGCTCTCTTCCCTCTTCGCCCCTTCGG
CTTGGCTCCTACAAGGCCCAGAAAACCAGCAGGTCCTCCAGCATCCCCTGCAGCGGTTCC
CTGGACGGGCGGGAGCTCTCCCGGCAGGTGCGGAGCTCCGTGGAACTGGAGCTAGAGCGG
TGCCGGCAGCAAGCAGGCCTCCTGGTGACCGGAGAGAAAGAGGAGCCCTCCCGCTCAGCC
TCAGAAGCAGACTCTGAAGCCGGAGAGCTGCGGAAGCCCACTCAGGAGGAGTGGAGGCAG
GTTGTAGATATCCTGTGGAGTGATCCCATGGCTCAAGAGGGCTGCAAGGCCAACACTATT
CGAGGAGGAGGCTGTTATTTTGGGCCTGATGTGACACAACAGTTGCTACAAAAATACAAC
ATGCAATTCCTGATCCGTTCACATGAATGCAAACCTGAAGGCTATGAATTCTGTCACAAC
CGCAAGGTATTAACAATCTTTTCTGCCTCCAACTACTATGAAGTTGGCAGCAACAGAGGG
GCCTATGTCAAACTGGGGCCAGCCCTGACCCCACATATTGTGCAGTATCAAGCTAACAAG
GTGACCCACACACTCACCATGAGGCAAAGGATTAGCAGAGTGGAGGAGTCGGCTCTGAGA
GCTCTGAGGGAGAAGCTGTTTGCTCATTCTTCAGATCTTCTCAGTGAATTTAAGAAGCAT
GATGCAGATAAAGTCGGTTTAATCACCTTGAGTGACTGGGCAGCAGCGGTGGAGTCTGTG
TTGCACCTAGGACTGCCATGGCGGATGCTGAGGCCACAGCTGGTGAACAGCTCAGCAGAC
AACATGCTGGAGTACAAGTCTTGGCTGAAGAACTTGGCCAAGGAACAACTGAGTCGCGAG
AACATACAATCAAGTTTGCTGGAAACATTGTATCGAAACCGATCCAACCTAGAGACCATT
TTTAGGATCATAGACAGTGATCATTCAGGGTTCATCTCACTGGACGAGTTCAGGCAGACC
TGGAAGCTGTTCAGCTCTCACATGAATATCGACATTACAGATGACTGCATCTGTGACCTT
GCTCGGAGCATTGATTTCAACAAAGATGGCCACATTGATATCAATGAGTTCCTGGAGGCC
TTCCGCCTTGTGGAGAAATCCTGCCCAGAGGGCGATGCCTCAGAATGCCCACAAGCTACA
AATGCTAAAGACAGTGGCTGCAGCAGTCCAGGTGCACACTAA

Protein Properties

Number of Residues

753

Molecular Weight

86517.3

Theoretical pI

7.133

Pfam Domain Function

Metallophos (PF00149 )
efhand (PF00036 )
PPP5 (PF08321 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Serine/threonine-protein phosphatase with EF-hands 2
MGSGTSTQHHFAFQNAERAFKAAALIQRWYRRYVARLEMRRRCTWSIFQSIEYAGQQDQV
KLHDFFSYLMDHFIPSSHNDRDFLTRIFTEDRFAQDSEMKKCSDYESIEVPDSYTGPRLS
FPLLPDHATALVEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTCYSEEITVCGDL
HGQLDDLIFIFYKNGLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGN
HEDHMVNLRYGFTKEVMNKYKVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDITD
LELLDKIERSKIVSTMRCKTRQKSEKQMEEKRRANQKSSAQGPIPWFLPESRSLPSSPLR
LGSYKAQKTSRSSSIPCSGSLDGRELSRQVRSSVELELERCRQQAGLLVTGEKEEPSRSA
SEADSEAGELRKPTQEEWRQVVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYN
MQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQYQANK
VTHTLTMRQRISRVEESALRALREKLFAHSSDLLSEFKKHDADKVGLITLSDWAAAVESV
LHLGLPWRMLRPQLVNSSADNMLEYKSWLKNLAKEQLSRENIQSSLLETLYRNRSNLETI
FRIIDSDHSGFISLDEFRQTWKLFSSHMNIDITDDCICDLARSIDFNKDGHIDINEFLEA
FRLVEKSCPEGDASECPQATNAKDSGCSSPGAH

External Links

GenBank ID Protein

23312386

UniProtKB/Swiss-Prot ID

O14830

UniProtKB/Swiss-Prot Entry Name

PPE2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_006239.2

GeneCard ID