Identification |
HMDB Protein ID
| CDBP00453 |
Secondary Accession Numbers
| Not Available |
Name
| Ferritin, mitochondrial |
Description
| Not Available |
Synonyms
|
Not Available
|
Gene Name
| FTMT |
Protein Type
| Metal Binding |
Biological Properties |
General Function
| Involved in oxidoreductase activity |
Specific Function
| Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
|
GO Classification
|
Biological Process |
positive regulation of cell proliferation |
cellular iron ion homeostasis |
positive regulation of oxidoreductase activity |
positive regulation of lyase activity |
positive regulation of transferase activity |
iron ion transport |
Cellular Component |
mitochondrion |
Function |
ion binding |
cation binding |
metal ion binding |
binding |
catalytic activity |
transition metal ion binding |
iron ion binding |
oxidoreductase activity |
ferric iron binding |
Molecular Function |
ferric iron binding |
ferroxidase activity |
Process |
establishment of localization |
cellular iron ion homeostasis |
transport |
biological regulation |
oxidation reduction |
ion transport |
cation transport |
metal ion transport |
transition metal ion transport |
iron ion transport |
regulation of biological quality |
homeostatic process |
chemical homeostasis |
ion homeostasis |
cellular ion homeostasis |
cellular cation homeostasis |
metabolic process |
cellular di-, tri-valent inorganic cation homeostasis |
|
Cellular Location
|
- Mitochondrion
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Porphyrin Metabolism | | | Porphyrin and chlorophyll metabolism | Not Available | | Mineral absorption | Not Available | | Acute Intermittent Porphyria | | Not Available | Porphyria Variegata (PV) | | Not Available |
|
Gene Properties |
Chromosome Location
| 5 |
Locus
| 5q21.3 |
SNPs
| FTMT |
Gene Sequence
|
>729 bp
ATGCTGTCCTGCTTCAGGCTCCTCTCCAGGCACATCAGCCCTTCGCTGGCGTCTCTGCGC
CCGGTGCGCTGCTGCTTCGCGCTCCCGCTGCGTTGGGCCCCGGGGCGCCCCTTGGACCCC
AGGCAGATCGCCCCCCGCCGCCCCCTGGCCGCAGCCGCCTCCTCCCGGGACCCTACCGGG
CCCGCCGCCGGCCCCTCTCGGGTGCGCCAGAACTTCCACCCCGACTCCGAGGCTGCCATC
AACCGCCAGATCAACCTCGAGCTCTATGCGTCCTACGTGTACTTGTCCATGGCCTATTAC
TTCTCCCGGGATGACGTGGCCTTGAACAACTTCTCCAGGTATTTCCTTCACCAGTCCCGG
GAGGAGACCGAGCACGCGGAGAAGCTGATGAGGCTGCAGAACCAGCGAGGAGGCCGGATC
CGCCTGCAGGACATCAAGAAGCCGGAACAGGACGACTGGGAAAGCGGGCTGCATGCCATG
GAGTGTGCTCTACTCTTGGAAAAGAACGTGAACCAGTCGTTGCTGGAATTGCACGCTCTA
GCCTCAGATAAAGGTGACCCCCATTTGTGCGATTTCCTGGAAACCTACTACCTGAATGAG
CAGGTGAAGTCTATCAAAGAACTAGGTGACCACGTGCACAACTTAGTGAAGATGGGGGCC
CCGGATGCTGGCCTGGCGGAGTACCTTTTTGACACACATACCCTTGGAAATGAAAACAAG
CAGAACTAA
|
Protein Properties |
Number of Residues
| 242 |
Molecular Weight
| 27537.885 |
Theoretical pI
| 7.276 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Ferritin, mitochondrial
MLSCFRLLSRHISPSLASLRPVRCCFALPLRWAPGRPLDPRQIAPRRPLAAAASSRDPTG
PAAGPSRVRQNFHPDSEAAINRQINLELYASYVYLSMAYYFSRDDVALNNFSRYFLHQSR
EETEHAEKLMRLQNQRGGRIRLQDIKKPEQDDWESGLHAMECALLLEKNVNQSLLELHAL
ASDKGDPHLCDFLETYYLNEQVKSIKELGDHVHNLVKMGAPDAGLAEYLFDTHTLGNENK
QN
|
External Links |
GenBank ID Protein
| 21707936 |
UniProtKB/Swiss-Prot ID
| Q8N4E7 |
UniProtKB/Swiss-Prot Entry Name
| FTMT_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| BC034419 |
GeneCard ID
| FTMT |
GenAtlas ID
| FTMT |
HGNC ID
| HGNC:17345 |
References |
General References
| Not Available |