| Identification |
|---|
| HMDB Protein ID
| CDBP00453 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ferritin, mitochondrial |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| FTMT |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
|
| GO Classification
|
| Biological Process |
| positive regulation of cell proliferation |
| cellular iron ion homeostasis |
| positive regulation of oxidoreductase activity |
| positive regulation of lyase activity |
| positive regulation of transferase activity |
| iron ion transport |
| Cellular Component |
| mitochondrion |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| iron ion binding |
| oxidoreductase activity |
| ferric iron binding |
| Molecular Function |
| ferric iron binding |
| ferroxidase activity |
| Process |
| establishment of localization |
| cellular iron ion homeostasis |
| transport |
| biological regulation |
| oxidation reduction |
| ion transport |
| cation transport |
| metal ion transport |
| transition metal ion transport |
| iron ion transport |
| regulation of biological quality |
| homeostatic process |
| chemical homeostasis |
| ion homeostasis |
| cellular ion homeostasis |
| cellular cation homeostasis |
| metabolic process |
| cellular di-, tri-valent inorganic cation homeostasis |
|
| Cellular Location
|
- Mitochondrion
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Porphyrin Metabolism |    |  | | Porphyrin and chlorophyll metabolism | Not Available | | | Mineral absorption | Not Available |  | | Acute Intermittent Porphyria |    | Not Available | | Porphyria Variegata (PV) |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| 5q21.3 |
| SNPs
| FTMT |
| Gene Sequence
|
>729 bp
ATGCTGTCCTGCTTCAGGCTCCTCTCCAGGCACATCAGCCCTTCGCTGGCGTCTCTGCGC
CCGGTGCGCTGCTGCTTCGCGCTCCCGCTGCGTTGGGCCCCGGGGCGCCCCTTGGACCCC
AGGCAGATCGCCCCCCGCCGCCCCCTGGCCGCAGCCGCCTCCTCCCGGGACCCTACCGGG
CCCGCCGCCGGCCCCTCTCGGGTGCGCCAGAACTTCCACCCCGACTCCGAGGCTGCCATC
AACCGCCAGATCAACCTCGAGCTCTATGCGTCCTACGTGTACTTGTCCATGGCCTATTAC
TTCTCCCGGGATGACGTGGCCTTGAACAACTTCTCCAGGTATTTCCTTCACCAGTCCCGG
GAGGAGACCGAGCACGCGGAGAAGCTGATGAGGCTGCAGAACCAGCGAGGAGGCCGGATC
CGCCTGCAGGACATCAAGAAGCCGGAACAGGACGACTGGGAAAGCGGGCTGCATGCCATG
GAGTGTGCTCTACTCTTGGAAAAGAACGTGAACCAGTCGTTGCTGGAATTGCACGCTCTA
GCCTCAGATAAAGGTGACCCCCATTTGTGCGATTTCCTGGAAACCTACTACCTGAATGAG
CAGGTGAAGTCTATCAAAGAACTAGGTGACCACGTGCACAACTTAGTGAAGATGGGGGCC
CCGGATGCTGGCCTGGCGGAGTACCTTTTTGACACACATACCCTTGGAAATGAAAACAAG
CAGAACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 242 |
| Molecular Weight
| 27537.885 |
| Theoretical pI
| 7.276 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Ferritin, mitochondrial
MLSCFRLLSRHISPSLASLRPVRCCFALPLRWAPGRPLDPRQIAPRRPLAAAASSRDPTG
PAAGPSRVRQNFHPDSEAAINRQINLELYASYVYLSMAYYFSRDDVALNNFSRYFLHQSR
EETEHAEKLMRLQNQRGGRIRLQDIKKPEQDDWESGLHAMECALLLEKNVNQSLLELHAL
ASDKGDPHLCDFLETYYLNEQVKSIKELGDHVHNLVKMGAPDAGLAEYLFDTHTLGNENK
QN
|
| External Links |
|---|
| GenBank ID Protein
| 21707936 |
| UniProtKB/Swiss-Prot ID
| Q8N4E7 |
| UniProtKB/Swiss-Prot Entry Name
| FTMT_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| BC034419 |
| GeneCard ID
| FTMT |
| GenAtlas ID
| FTMT |
| HGNC ID
| HGNC:17345 |
| References |
|---|
| General References
| Not Available |