Identification
HMDB Protein ID CDBP02224
Secondary Accession Numbers Not Available
Name Cytochrome b reductase 1
Description Not Available
Synonyms
  1. Duodenal cytochrome b
  2. Ferric-chelate reductase 3
Gene Name CYBRD1
Protein Type Enzyme
Biological Properties
General Function Involved in ferric-chelate reductase activity
Specific Function Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells
GO Classification
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:2
Locus 2q31.1
SNPs CYBRD1
Gene Sequence
>861 bp
ATGGCCATGGAGGGCTACTGGCGCTTCCTGGCGCTGCTGGGGTCGGCACTGCTCGTCGGC
TTCCTGTCGGTGATCTTCGCCCTCGTCTGGGTCCTCCACTACCGAGAGGGGCTTGGCTGG
GATGGGAGCGCACTAGAGTTTAACTGGCACCCAGTGCTCATGGTCACCGGCTTCGTCTTC
ATCCAGGGCATCGCCATCATCGTCTACAGACTGCCGTGGACCTGGAAATGCAGCAAGCTC
CTGATGAAATCCATCCATGCAGGGTTAAATGCAGTTGCTGCCATTCTTGCAATTATCTCT
GTGGTGGCCGTGTTTGAGAACCACAATGTTAACAATATAGCCAATATGTACAGTCTGCAC
AGCTGGGTTGGACTGATAGCTGTCATATGCTATTTGTTACAGCTTCTTTCAGGTTTTTCA
GTCTTTCTGCTTCCATGGGCTCCGCTTTCTCTCCGAGCATTTCTCATGCCCATACATGTT
TATTCTGGAATTGTCATCTTTGGAACAGTGATTGCAACAGCACTTATGGGATTGACAGAG
AAACTGATTTTTTCCCTGAGAGATCCTGCATACAGTACATTCCCGCCAGAAGGTGTTTTC
GTAAATACGCTTGGCCTTCTGATCCTGGTGTTCGGGGCCCTCATTTTTTGGATAGTCACC
AGACCGCAATGGAAACGTCCTAAGGAGCCAAATTCTACCATTCTTCATCCAAATGGAGGC
ACTGAACAGGGAGCAAGAGGTTCCATGCCAGCCTACTCTGGCAACAACATGGACAAATCA
GATTCAGAGTTAAACAGTGAAGTAGCAGCAAGGAAAAGAAACTTAGCTCTGGATGAGGCT
GGGCAGAGATCTACCATGTAA
Protein Properties
Number of Residues 286
Molecular Weight 31641.0
Theoretical pI 9.02
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["12-32", "49-69", "85-105", "123-143", "158-178", "199-219"]
Protein Sequence
>Cytochrome b reductase 1
MAMEGYWRFLALLGSALLVGFLSVIFALVWVLHYREGLGWDGSALEFNWHPVLMVTGFVF
IQGIAIIVYRLPWTWKCSKLLMKSIHAGLNAVAAILAIISVVAVFENHNVNNIANMYSLH
SWVGLIAVICYLLQLLSGFSVFLLPWAPLSLRAFLMPIHVYSGIVIFGTVIATALMGLTE
KLIFSLRDPAYSTFPPEGVFVNTLGLLILVFGALIFWIVTRPQWKRPKEPNSTILHPNGG
TEQGARGSMPAYSGNNMDKSDSELNSEVAARKRNLALDEAGQRSTM
GenBank ID Protein 62822181
UniProtKB/Swiss-Prot ID Q53TN4
UniProtKB/Swiss-Prot Entry Name CYBR1_HUMAN
PDB IDs Not Available
GenBank Gene ID AC007969
GeneCard ID CYBRD1
GenAtlas ID CYBRD1
HGNC ID HGNC:20797
References
General References Not Available