Identification |
HMDB Protein ID
| CDBP01970 |
Secondary Accession Numbers
| Not Available |
Name
| Cysteine desulfurase, mitochondrial |
Description
| Not Available |
Synonyms
|
Not Available
|
Gene Name
| NFS1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in metabolic process |
Specific Function
| Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor.
|
GO Classification
|
Biological Process |
iron incorporation into metallo-sulfur cluster |
cysteine metabolic process |
sulfur amino acid metabolic process |
molybdopterin cofactor biosynthetic process |
water-soluble vitamin metabolic process |
Mo-molybdopterin cofactor biosynthetic process |
protein complex assembly |
Cellular Component |
cytosol |
mitochondrial matrix |
nucleus |
Function |
sulfurtransferase activity |
cysteine desulfurase activity |
binding |
catalytic activity |
transferase activity |
transferase activity, transferring sulfur-containing groups |
cofactor binding |
pyridoxal phosphate binding |
Molecular Function |
pyridoxal phosphate binding |
protein homodimerization activity |
cysteine desulfurase activity |
Process |
metabolic process |
cysteine metabolic process |
cellular metabolic process |
sulfur amino acid metabolic process |
cellular amino acid and derivative metabolic process |
cellular amino acid metabolic process |
|
Cellular Location
|
- Nucleus
- Cytoplasm
- Mitochondrion
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Sulfur relay system | Not Available | |
|
Gene Properties |
Chromosome Location
| 20 |
Locus
| 20q11.22 |
SNPs
| NFS1 |
Gene Sequence
|
>1374 bp
ATGCTGCTCCGAGTCGCTTGGAGGCGGGCGGCAGTGGCGGTGACAGCGGCTCCAGGGCCG
AAGCCCGCGGCGCCCACTCGGGGGCTGCGCCTGCGCGTTGGAGACCGTGCTCCTCAGTCT
GCGGTTCCCGCAGATACAACCGCTGCCCCGGAGGTGGGGCCAGTGCTGCGACCTCTCTAT
ATGGATGTGCAAGCTACAACTCCTCTGGACCCCCGGGTGCTTGATGCCATGCTCCCTTAC
CTAATCAACTACTATGGGAACCCACACTCCCGGACACATGCTTATGGCTGGGAGAGTGAG
GCAGCCATGGAACGTGCTCGTCAGCAAGTAGCATCTCTGATTGGAGCTGATCCTCGTGAG
ATCATTTTTACTAGTGGTGCTACTGAATCCAACAACATAGCAATTAAGGGGGTGGCCCGA
TTCTACAGGTCACGGAAAAAGCACTTGATCACCACCCAGACAGAACACAAATGTGTCTTG
GACTCCTGCCGTTCACTGGAAGCTGAGGGCTTTCAGGTCACCTACCTCCCAGTGCAGAAG
AGTGGGATCATTGACCTAAAGGAACTAGAGGCTGCTATCCAGCCAGATACTAGCCTGGTG
TCAGTCATGACTGTGAACAATGAGATTGGAGTGAAGCAGCCTATTGCAGAAATAGGGCGG
ATTTGCAGTTCCAGAAAGGTATATTTCCATACTGATGCAGCCCAGGCTGTTGGAAAAATC
CCACTTGATGTCAATGACATGAAAATTGATCTCATGAGCATTAGTGGTCACAAAATCTAC
GGTCCCAAAGGGGTTGGTGCCATCTACATCCGTCGCCGGCCCCGTGTGCGTGTGGAGGCC
CTGCAGAGTGGAGGGGGGCAGGAGCGGGGTATGCGGTCTGGGACAGTGCCCACACCCTTA
GTGGTGGGGTTGGGGGCTGCGTGTGAGGTGGCACAGCAAGAGATGGAGTATGACCACAAG
CGAATCTCAAAGTTGTCAGAGCGGCTGATACAGAATATAATGAAGAGCCTTCCAGATGTG
GTGATGAATGGGGACCCTAAGCACCATTATCCCGGCTGTATCAACCTCTCCTTTGCATAT
GTGGAAGGGGAAAGTCTGCTGATGGCACTGAAGGACGTTGCCTTATCCTCAGGGAGTGCC
TGCACCTCTGCATCCCTGGAGCCCTCTTATGTGCTTAGAGCAATTGGCACTGATGAGGAT
TTAGCGCACTCTTCTATCAGGTTTGGAATTGGCGCTTTCACTACAGAGGAGGAAGTGGAC
TACACAGTGGAGAAATGCATTCAGCATGTGAATCGTCTTCGAGAAATGAGCCCTCTCTGG
GAGATGGTTCAGGATGGCATTGACCTCAAGAGCATCAAGTGGACCCAACACTAG
|
Protein Properties |
Number of Residues
| 457 |
Molecular Weight
| 44361.485 |
Theoretical pI
| 7.544 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Cysteine desulfurase, mitochondrial
MLLRAAWRRAAVAVTAAPGPKPAAPTRGLRLRVGDRAPQSAVPADTAAAPEVGPVLRPLY
MDVQATTPLDPRVLDAMLPYLINYYGNPHSRTHAYGWESEAAMERARQQVASLIGADPRE
IIFTSGATESNNIAIKGVARFYRSRKKHLITTQTEHKCVLDSCRSLEAEGFQVTYLPVQK
SGIIDLKELEAAIQPDTSLVSVMTVNNEIGVKQPIAEIGRICSSRKVYFHTDAAQAVGKI
PLDVNDMKIDLMSISGHKIYGPKGVGAIYIRRRPRVRVEALQSGGGQERGMRSGTVPTPL
VVGLGAACEVAQQEMEYDHKRISKLSERLIQNIMKSLPDVVMNGDPKHHYPGCINLSFAY
VEGESLLMALKDVALSSGSACTSASLEPSYVLRAIGTDEDLAHSSIRFGIGRFTTEEEVD
YTVEKCIQHVKRLREMSPLWEMVQDGIDLKSIKWTQH
|
External Links |
GenBank ID Protein
| 24042327 |
UniProtKB/Swiss-Prot ID
| Q9Y697 |
UniProtKB/Swiss-Prot Entry Name
| NFS1_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AF097025 |
GeneCard ID
| NFS1 |
GenAtlas ID
| NFS1 |
HGNC ID
| HGNC:15910 |
References |
General References
| Not Available |