Identification |
HMDB Protein ID
| CDBP03837 |
Secondary Accession Numbers
| Not Available |
Name
| ATP-binding cassette sub-family B member 7, mitochondrial |
Description
| Not Available |
Synonyms
|
- ABC transporter 7 protein
- ATP-binding cassette transporter 7
|
Gene Name
| ABCB7 |
Protein Type
| Transporter |
Biological Properties |
General Function
| Involved in ATP binding |
Specific Function
| Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins |
GO Classification
|
Component |
cell part |
membrane part |
intrinsic to membrane |
integral to membrane |
Function |
purine nucleoside binding |
adenyl nucleotide binding |
adenyl ribonucleotide binding |
atp binding |
transmembrane transporter activity |
atpase activity |
transporter activity |
active transmembrane transporter activity |
nucleoside-triphosphatase activity |
primary active transmembrane transporter activity |
hydrolase activity, acting on acid anhydrides |
p-p-bond-hydrolysis-driven transmembrane transporter activity |
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
atpase activity, coupled to transmembrane movement of substances |
pyrophosphatase activity |
binding |
nucleotide binding |
catalytic activity |
hydrolase activity |
nucleoside binding |
Process |
establishment of localization |
transport |
transmembrane transport |
|
Cellular Location
|
- Multi-pass membrane protein (Potential)
- Mitochondrion inner membrane
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| ABCB7 |
Gene Sequence
|
>2259 bp
ATGGCGCTGCTCGCGATGCATTCTTGGCGCTGGGCGGCCGCGGCGGCTGCTTTCGAAAAG
CGCCGGCACTCCGCGATTCTGATCCGGCCTTTAGTCTCTGTTAGCGGCTCAGGTCCGCAG
TGGAGGCCACATCAACTCGGCGCCTTGGGAACCGCTCGAGCCTACCAGATTCCAGAGTCA
TTAAAAAGTATCACATGGCAGAGATTGGGAAAAGGCAATTCAGGACAGTTCTTAGATGCT
GCAAAGGCTCTCCAGGTATGGCCACTGATAGAAAAGAGGACATGTTGGCATGGTCATGCA
GGAGGAGGACTCCACACAGACCCAAAAGAAGGGTTAAAAGATGTTGATACTCGGAAAATC
ATAAAAGCAATGCTTTCTTATGTGTGGCCCAAAGACAGGCCAGATCTACGAGCTAGAGTT
GCCATTTCGCTGGGATTTTTGGGTGGTGCAAAGGCCATGAATATTGTGGTTCCCTTCATG
TTTAAATATGCTGTAGACAGCCTCAACCAGATGTCGGGAAACATGCTGAACCTGAGTGAT
GCACCAAATACAGTTGCAACCATGGCAACAGCAGTTCTGATTGGCTATGGTGTATCAAGA
GCTGGAGCTGCTTTTTTTAACGAAGTTCGAAATGCAGTATTTGGCAAGGTAGCCCAGAAT
TCAATCCGAAGAATAGCCAAAAATGTCTTTCTCCATCTTCACAACCTGGATCTGGGTTTT
CACCTGAGCAGACAGACGGGAGCTTTATCTAAGGCTATTGACAGAGGAACAAAGGGTATC
AGTTTTGTCCTGAGTGCTTTGGTATTTAATCTTCTTCCCATCATGTTTGAAGTGATGCTT
GTCAGTGGTGTTTTGTATTACAAATGCGGTGCCCAGTTTGCTTTGGTAACCCTTGGAACA
CTTGGTACATACACAGCATTCACAGTTGCAGTCACACGGTGGGGAACTAGATTTAGAATA
GAAATGAACAAAGCAGATAATGATGCAGGTAATGCTGCTATAGACTCACTGCTGAATTAT
GAAACTGTGAAGTATATTAATAATGAAAGATATGAAGCACAGAGATATGATGGATTTTTG
AAGACGTATGAGACTGCTTCATTGAAAAGTACCTCTACTCTGGCTATGCTGAACTTTGGT
CAAAGTGCTATTTTCAGTGTCGGTTTAACAGCTATAATGGTGCTCGCCAGTCAGGGAATT
GTGGCAGGTACCCTTACTGTTGGAGATCTAGTAATGGTGAATGGACTGCTTTTTCAGCTT
TCATTACCCCTGAACTTTCTGGGAACTGTATATAGAGAGACTAGACAAGCACTCATAGAT
ATGAACACCTTGTTTACTCTACTCAAGGTAGACACCCAAATTAAAGACAAAGTGATGGCA
TCTCCCCTTCAGATCACACCACAGACAGCTACCGTGGCCTTTGATAATGTGCATTTTGAA
TACATTGAGGGCCAGAAAGTCCTTAGTGGAATATCCTTTGAAGTCCCTGCAGGAAAGAAA
GTGGCCATTGTAGGAGGTAGTGGGTCAGGGAAAAGCACAATAGTGAGGCTATTATTTCGC
TTCTATGAGCCTCAAAAGGGTAGCATTTATCTTGCTGGTCAAAATATACAAGATGTGAGC
CTGGAAAGCCTTCGGAGGGCAGTGGGAGTGGTACCTCAGGATGCTGTCCTCTTCCATAAT
ACTATTTATTACAACCTCTTATATGGAAACATCAGTGCTTCACCTGAGGAAGTGTATGCA
GTGGCAAAATTAGCTGGACTTCATGATGCAATTCTTCGAATGCCACATGGATATGACACC
CAAGTAGGGGAACGAGGACTCAAGCTTTCAGGAGGAGAAAAGCAAAGAGTAGCAATTGCA
AGAGCCATTTTGAAGGACCCCCCAGTCATACTCTATGATGAAGCTACTTCATCGTTAGAT
TCGATTACTGAAGAGACTATTCTTGGTGCCATGAAGGATGTGGTCAAACACAGAACTTCT
ATTTTCATTGCACACAGATTGTCAACAGTGGTTGATGCAGATGAAATCATTGTCTTGGAT
CAGGGTAAGGTAGCCGAACGTGGTACCCACCATGGTTTGCTTGCTAACCCTCATAGTATC
TATTCAGAAATGTGGCATACACAGAGCAGCCGTGTGCAGAACCATGATAACCCCAAATGG
GAAGCAAAGAAAGAAAATATATCCAAAGAGGAGGAAAGAAAGAAACTACAAGAAGAAATT
GTCAATAGTGTGAAAGGCTGTGGAAACTGTTCGTGCTAA
|
Protein Properties |
Number of Residues
| 752 |
Molecular Weight
| 82640.6 |
Theoretical pI
| 9.79 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
- ["141-161", "186-206", "260-280", "291-311", "383-403", "410-430"]
|
Protein Sequence
|
>ATP-binding cassette sub-family B member 7, mitochondrial
MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQIPES
LKSITWQRLGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRKI
IKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLSD
APNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGF
HLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGT
LGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFL
KTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQL
SLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFE
YIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVS
LESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDT
QVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTS
IFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPKW
EAKKENISKEEERKKLQEEIVNSVKGCGNCSC
|
External Links |
GenBank ID Protein
| 3228279 |
UniProtKB/Swiss-Prot ID
| O75027 |
UniProtKB/Swiss-Prot Entry Name
| ABCB7_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AB005289 |
GeneCard ID
| ABCB7 |
GenAtlas ID
| ABCB7 |
HGNC ID
| HGNC:48 |
References |
General References
| Not Available |