Cannabis Compound Database: Showing Protein 3-hydroxyanthranilate 3,4-dioxygenase (CDBP01061)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP01061

Secondary Accession Numbers

Not Available

Name

3-hydroxyanthranilate 3,4-dioxygenase

Description

Not Available

Synonyms

3-HAO
3-hydroxyanthranilate oxygenase
3-hydroxyanthranilic acid dioxygenase
HAD

Gene Name

HAAO

Protein Type

Enzyme

Biological Properties

General Function

Involved in 3-hydroxyanthranilate 3,4-dioxygenase activity

Specific Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.

GO Classification

Biological Process
tryptophan catabolic process
NAD biosynthetic process
neuron homeostasis
quinolinate biosynthetic process
response to cadmium ion
response to zinc ion
Cellular Component
cytosol
mitochondrial membrane
Component
cell part
intracellular part
cytoplasm
Function
3-hydroxyanthranilate 3,4-dioxygenase activity
ion binding
cation binding
metal ion binding
binding
catalytic activity
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
transition metal ion binding
iron ion binding
oxidoreductase activity
Molecular Function
3-hydroxyanthranilate 3,4-dioxygenase activity
electron carrier activity
ferrous iron binding
oxygen binding
Process
metabolic process
oxidation reduction

Cellular Location

Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
NAD(+) biosynthesis	Not Available	Not Available
Tyrosine Metabolism
Alkaptonuria		Not Available
Hawkinsinuria		Not Available
Tyrosinemia Type I		Not Available

Gene Properties

Chromosome Location

Locus

2p21

SNPs

HAAO

Gene Sequence

>861 bp
ATGGAGCGCCGCCTGGGAGTGAGGGCCTGGGTGAAGGAGAACCGGGGCTCCTTCCAGCCC
CCGGTCTGCAACAAGCTCATGCACCAGGAGCAGCTCAAAGTCATGTTCATCGGAGGCCCC
AACACCAGGAAGGACTATCACATCGAAGAGGGTGAAGAGGTATTTTACCAGCTGGAGGGA
GACATGGTTCTCCGAGTCCTGGAGCAAGGGAAACACCGGGATGTGGTCATTCGGCAGGGA
GAGATATTCCTCCTGCCTGCCAGGGTGCCCCACTCACCACAGAGGTTTGCCAACACCGTG
GGGCTGGTGGTTGAGCGAAGGCGGCTGGAGACCGAGCTAGATGGGCTCAGGTACTATGTG
GGCGACACCATGGACGTTCTGTTTGAGAAGTGGTTCTACTGCAAGGACCTCGGCACGCAG
TTGGCCCCCATCATCCAGGAGTTCTTCAGCTCTGAGCAGTACAGAACAGGAAAGCCCATC
CCTGACCAGCTGCTCAAGGAGCCACCATTCCCTCTGAGCACACGATCCATCATGGAGCCC
ATGTCCCTGGATGCCTGGCTGGACAGCCACCACAGGGAGCTGCAGGCAGGCACACCACTC
AGCCTGTTTGGGGACACCTATGAGACCCAGGTGATCGCCTATGGGCAAGGCAGCAGCGAA
GGCCTGAGACAGAATGTGGACGTGTGGCTGTGGCAGCTGGAGGGCTCCTCGGTGGTGACA
ATGGGGGGACGGCGCCTGAGCCTGGCCCCTGATGACAGCCTCCTGGTGCTAGCTGGGACC
TCGTATGCCTGGGAGCGAACACAAGGCTCTGTGGCCCTGTCTGTGACCCAGGACCCTGCC
TGCAAGAAGCCCCTGGGGTGA

Protein Properties

Number of Residues

286

Molecular Weight

32555.935

Theoretical pI

5.889

Pfam Domain Function

3-HAO (PF06052 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>3-hydroxyanthranilate 3,4-dioxygenase
MERRLGVRAWVKENRGSFQPPVCNKLMHQEQLKVMFIGGPNTRKDYHIEEGEEVFYQLEG
DMVLRVLEQGKHRDVVIRQGEIFLLPARVPHSPQRFANTVGLVVERRRLETELDGLRYYV
GDTMDVLFEKWFYCKDLGTQLAPIIQEFFSSEQYRTGKPIPDQLLKEPPFPLSTRSIMEP
MSLDAWLDSHHRELQAGTPLSLFGDTYETQVIAYGQGSSEGLRQNVDVWLWQLEGSSVVT
MGGRRLSLAPDDSLLVLAGTSYAWERTQGSVALSVTQDPACKKPLG

External Links

GenBank ID Protein

62822152

UniProtKB/Swiss-Prot ID

P46952

UniProtKB/Swiss-Prot Entry Name

3HAO_HUMAN

PDB IDs