Identification |
HMDB Protein ID
| CDBP01061 |
Secondary Accession Numbers
| Not Available |
Name
| 3-hydroxyanthranilate 3,4-dioxygenase |
Description
| Not Available |
Synonyms
|
- 3-HAO
- 3-hydroxyanthranilate oxygenase
- 3-hydroxyanthranilic acid dioxygenase
- HAD
|
Gene Name
| HAAO |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in 3-hydroxyanthranilate 3,4-dioxygenase activity |
Specific Function
| Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
|
GO Classification
|
Biological Process |
tryptophan catabolic process |
NAD biosynthetic process |
neuron homeostasis |
quinolinate biosynthetic process |
response to cadmium ion |
response to zinc ion |
Cellular Component |
cytosol |
mitochondrial membrane |
Component |
cell part |
intracellular part |
cytoplasm |
Function |
3-hydroxyanthranilate 3,4-dioxygenase activity |
ion binding |
cation binding |
metal ion binding |
binding |
catalytic activity |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
transition metal ion binding |
iron ion binding |
oxidoreductase activity |
Molecular Function |
3-hydroxyanthranilate 3,4-dioxygenase activity |
electron carrier activity |
ferrous iron binding |
oxygen binding |
Process |
metabolic process |
oxidation reduction |
|
Cellular Location
|
- Cytoplasm
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | NAD(+) biosynthesis | Not Available | Not Available | Tyrosine Metabolism | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000142/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000142/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000142/thumb?image_type=simple) | ![Map00350](https://www.genome.jp/kegg/misc/thumbnail/map00350.gif) | Alkaptonuria | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000180/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000180/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000180/thumb?image_type=simple) | Not Available | Hawkinsinuria | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000181/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000181/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000181/thumb?image_type=simple) | Not Available | Tyrosinemia Type I | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000182/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000182/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000182/thumb?image_type=simple) | Not Available |
|
Gene Properties |
Chromosome Location
| 2 |
Locus
| 2p21 |
SNPs
| HAAO |
Gene Sequence
|
>861 bp
ATGGAGCGCCGCCTGGGAGTGAGGGCCTGGGTGAAGGAGAACCGGGGCTCCTTCCAGCCC
CCGGTCTGCAACAAGCTCATGCACCAGGAGCAGCTCAAAGTCATGTTCATCGGAGGCCCC
AACACCAGGAAGGACTATCACATCGAAGAGGGTGAAGAGGTATTTTACCAGCTGGAGGGA
GACATGGTTCTCCGAGTCCTGGAGCAAGGGAAACACCGGGATGTGGTCATTCGGCAGGGA
GAGATATTCCTCCTGCCTGCCAGGGTGCCCCACTCACCACAGAGGTTTGCCAACACCGTG
GGGCTGGTGGTTGAGCGAAGGCGGCTGGAGACCGAGCTAGATGGGCTCAGGTACTATGTG
GGCGACACCATGGACGTTCTGTTTGAGAAGTGGTTCTACTGCAAGGACCTCGGCACGCAG
TTGGCCCCCATCATCCAGGAGTTCTTCAGCTCTGAGCAGTACAGAACAGGAAAGCCCATC
CCTGACCAGCTGCTCAAGGAGCCACCATTCCCTCTGAGCACACGATCCATCATGGAGCCC
ATGTCCCTGGATGCCTGGCTGGACAGCCACCACAGGGAGCTGCAGGCAGGCACACCACTC
AGCCTGTTTGGGGACACCTATGAGACCCAGGTGATCGCCTATGGGCAAGGCAGCAGCGAA
GGCCTGAGACAGAATGTGGACGTGTGGCTGTGGCAGCTGGAGGGCTCCTCGGTGGTGACA
ATGGGGGGACGGCGCCTGAGCCTGGCCCCTGATGACAGCCTCCTGGTGCTAGCTGGGACC
TCGTATGCCTGGGAGCGAACACAAGGCTCTGTGGCCCTGTCTGTGACCCAGGACCCTGCC
TGCAAGAAGCCCCTGGGGTGA
|
Protein Properties |
Number of Residues
| 286 |
Molecular Weight
| 32555.935 |
Theoretical pI
| 5.889 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>3-hydroxyanthranilate 3,4-dioxygenase
MERRLGVRAWVKENRGSFQPPVCNKLMHQEQLKVMFIGGPNTRKDYHIEEGEEVFYQLEG
DMVLRVLEQGKHRDVVIRQGEIFLLPARVPHSPQRFANTVGLVVERRRLETELDGLRYYV
GDTMDVLFEKWFYCKDLGTQLAPIIQEFFSSEQYRTGKPIPDQLLKEPPFPLSTRSIMEP
MSLDAWLDSHHRELQAGTPLSLFGDTYETQVIAYGQGSSEGLRQNVDVWLWQLEGSSVVT
MGGRRLSLAPDDSLLVLAGTSYAWERTQGSVALSVTQDPACKKPLG
|
External Links |
GenBank ID Protein
| 62822152 |
UniProtKB/Swiss-Prot ID
| P46952 |
UniProtKB/Swiss-Prot Entry Name
| 3HAO_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| AC098824 |
GeneCard ID
| HAAO |
GenAtlas ID
| HAAO |
HGNC ID
| HGNC:4796 |
References |
General References
| Not Available |