| Identification |
|---|
| HMDB Protein ID
| CDBP00116 |
| Secondary Accession Numbers
| Not Available |
| Name
| Succinate dehydrogenase cytochrome b560 subunit, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- CYBL
- Integral membrane protein CII-3
- QPs-1
- QPs1
- Succinate dehydrogenase complex subunit C
- Succinate-ubiquinone oxidoreductase cytochrome B large subunit
- SubName: cDNA FLJ57876, highly similar to Homo sapiens succinate dehydrogenase complex, subunit C, transcript variant 2, mRNA
- SubName: Succinate dehydrogenase complex, subunit C delta3 alternative splicing variant
- SubName: Succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa, isoform CRA_g
|
| Gene Name
| SDHC |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in succinate dehydrogenase activity |
| Specific Function
| Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| tricarboxylic acid cycle |
| respiratory electron transport chain |
| Cellular Component |
| mitochondrial respiratory chain complex II |
| integral to membrane |
| Component |
| plasma membrane succinate dehydrogenase complex |
| membrane |
| cell part |
| membrane part |
| plasma membrane part |
| Function |
| oxidoreductase activity, acting on the ch-ch group of donors |
| catalytic activity |
| electron carrier activity |
| succinate dehydrogenase activity |
| oxidoreductase activity |
| Molecular Function |
| electron carrier activity |
| metal ion binding |
| heme binding |
| succinate dehydrogenase activity |
| Process |
| tricarboxylic acid cycle |
| metabolic process |
| cellular metabolic process |
| cofactor metabolic process |
| coenzyme metabolic process |
| acetyl-coa metabolic process |
| acetyl-coa catabolic process |
|
| Cellular Location
|
- Mitochondrion inner membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | tricarboxylic acid cycle | Not Available | Not Available | | Citrate cycle (TCA cycle) | Not Available |  | | Oxidative phosphorylation | Not Available |  | | Alzheimer's disease | Not Available |  | | Parkinson's disease | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1q23.3 |
| SNPs
| SDHC |
| Gene Sequence
|
>510 bp
ATGGCTGCGCTGTTGCTGAGACACGTTGGTCGTCATTGCCTCCGAGCCCACTTTAGCCCT
CAGCTCTGTATCAGAAATGCTGTTCCTTTGGGAACCACGGCCAAAGAAGAGATGGAGCGG
TTCTGGAATAAGAATATAGGTTCAAACCGTCCTCTGTCTCCCCACATTACTATCTACAGT
TGGTCTCTTCCCATGGCGATGTCCATCTGCCACCGTGGCACTGGTATTGCTTTGAGTGCA
GGGGTCTCTCTTTTTGGCATGTCGGCCCTGTTACTCCCTGGGAACTTTGAGTCTTATTTG
GAACTTGTGAAGTCCCTGTGTCTGGGGCCAGCACTGATCCACACAGCTAAGTTTGCACTT
GTCTTCCCTCTCATGTATCATACCTGGAATGGGATCCGACACTTGATGTGGGACCTAGGA
AAAGGCCTGAAGATTCCCCAGCTATACCAGTCTGGAGTGGTTGTCCTGGTTCTTACTGTG
TTGTCCTCTATGGGGCTGGCAGCCATGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 169 |
| Molecular Weight
| 16650.185 |
| Theoretical pI
| 9.307 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
MAALLLRHVGRHCLRAHFSPQLCIRNAVPLGTTAKEEMERFWNKNIGSNRPLSPHITIYS
WSLPMAMSICHRGTGIALSAGVSLFGMSALLLPGNFESYLELVKSLCLGPALIHTAKFAL
VFPLMYHTWNGIRHLMWDLGKGLKIPQLYQSGVVVLVLTVLSSMGLAAM
|
| External Links |
|---|
| GenBank ID Protein
| 78096641 |
| UniProtKB/Swiss-Prot ID
| Q99643 |
| UniProtKB/Swiss-Prot Entry Name
| C560_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U57877 |
| GeneCard ID
| SDHC |
| GenAtlas ID
| SDHC |
| HGNC ID
| HGNC:10682 |
| References |
|---|
| General References
| Not Available |