Showing Protein Fatty acid 2-hydroxylase (CDBP03855)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 compounds
Identification
HMDB Protein ID CDBP03855
Secondary Accession Numbers Not Available
Name Fatty acid 2-hydroxylase
Description Not Available
Synonyms
  1. Fatty acid alpha-hydroxylase
Gene Name FA2H
Protein Type Enzyme
Biological Properties
General Function Involved in heme binding
Specific Function Required for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids
GO Classification
Component
endoplasmic reticulum
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
transition metal ion binding
iron ion binding
heme binding
oxidoreductase activity
Process
sphingolipid metabolic process
membrane lipid metabolic process
primary metabolic process
cellular metabolic process
organic acid metabolic process
oxoacid metabolic process
carboxylic acid metabolic process
monocarboxylic acid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
oxidation reduction
lipid metabolic process
cellular lipid metabolic process
metabolic process
Cellular Location
  1. Endoplasmic reticulum membrane
  2. Multi-pass membrane protein
  3. Multi-pass membrane protein
  4. Microsome membrane
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 16q23
SNPs FA2H
Gene Sequence 
>1119 bp
ATGGCCCCCGCTCCGCCCCCCGCCGCCTCCTTCTCGCCCTCCGAGGTCCAGCGGCGCCTG
GCGGCCGGCGCGTGCTGGGTCCGCCGCGGGGCCCGCCTCTACGACCTCTCCAGCTTCGTG
CGGCACCACCCGGGGGGCGAGCAGCTGCTGCGGGCCAGGGCGGGCCAGGACATCAGCGCC
GACCTGGACGGGCCGCCGCACAGGCACTCGGCCAACGCGCGCCGCTGGCTGGAGCAGTAC
TACGTGGGAGAGCTCCGCGGGGAGCAGCAGGGCTCCATGGAGAACGAGCCTGTAGCCCTT
GAGGAAACTCAGAAGACAGATCCTGCTATGGAACCACGGTTCAAAGTGGTGGATTGGGAC
AAGGACCTGGTGGACTGGCGAAAGCCTCTCCTGTGGCAGGTGGGCCACTTGGGAGAGAAG
TACGATGAGTGGGTTCACCAGCCGGTGACCAGGCCCATCCGCCTCTTCCACTCAGACCTC
ATTGAGGGCCTCTCTAAGACTGTCTGGTACAGTGTCCCCATCATCTGGGTGCCCCTGGTG
CTGTATCTCAGCTGGTCCTACTACCGAACCTTTGCCCAGGGCAACGTCCGACTCTTCACG
TCATTTACAACAGAGTACACGGTGGCAGTGCCCAAGTCCATGTTCCCCGGGCTCTTCATG
CTGGGGACATTCCTCTGGAGCCTCATCGAGTACCTCATCCACCGCTTCCTGTTCCACATG
AAGCCCCCCAGCGACAGCTATTACCTCATCATGCTGCACTTCGTCATGCACGGCCAGCAC
CACAAGGCACCCTTCGACGGCTCCCGCCTGGTCTTCCCCCCTGTGCCAGCCTCCCTGGTG
ATCGGCGTCTTCTACTTGTGCATGCAGCTCATCCTGCCCGAGGCAGTAGGGGGCACTGTG
TTTGCGGGGGGCCTCCTGGGCTACGTCCTCTATGACATGACCCATTACTACCTGCACTTT
GGCTCGCCGCACAAGGGCTCCTACCTGTACAGCCTGAAGGCCCACCACGTCAAGCACCAC
TTTGCACATCAGAAGTCAGGATTTGGTATCAGCACTAAATTGTGGGATTACTGTTTCCAC
ACCCTCACTCCAGAGAAACCCCACCTGAAGACGCAGTGA
Protein Properties
Number of Residues 372
Molecular Weight 42791.0
Theoretical pI 8.88
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["168-188", "213-233", "268-288", "290-310"]
Protein Sequence 
>Fatty acid 2-hydroxylase
MAPAPPPAASFSPSEVQRRLAAGACWVRRGARLYDLSSFVRHHPGGEQLLRARAGQDISA
DLDGPPHRHSANARRWLEQYYVGELRGEQQGSMENEPVALEETQKTDPAMEPRFKVVDWD
KDLVDWRKPLLWQVGHLGEKYDEWVHQPVTRPIRLFHSDLIEGLSKTVWYSVPIIWVPLV
LYLSWSYYRTFAQGNVRLFTSFTTEYTVAVPKSMFPGLFMLGTFLWSLIEYLIHRFLFHM
KPPSDSYYLIMLHFVMHGQHHKAPFDGSRLVFPPVPASLVIGVFYLCMQLILPEAVGGTV
FAGGLLGYVLYDMTHYYLHFGSPHKGSYLYSLKAHHVKHHFAHQKSGFGISTKLWDYCFH
TLTPEKPHLKTQ
GenBank ID Protein 205360949
UniProtKB/Swiss-Prot ID Q7L5A8
UniProtKB/Swiss-Prot Entry Name FA2H_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_024306.4
GeneCard ID FA2H
GenAtlas ID FA2H
HGNC ID HGNC:21197
References
General References Not Available