Cannabis Compound Database: Showing Compound Card for Oxygen (CDB004910)

Jump To Section:

Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (151)transporters (1) Show 318 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 18:49:32 UTC

Updated at

2020-11-18 16:38:59 UTC

CannabisDB ID

CDB004910

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Oxygen

Description

Oxygen, also known as dioxygene or O2, belongs to the class of inorganic compounds known as other non-metal oxides. These are inorganic compounds containing an oxygen atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen belongs to the class of 'other non-metals'. Oxygen is possibly neutral. Oxygen exists in all living species, ranging from bacteria to humans. In humans, oxygen is involved in ibuprofen action pathway. Outside of the human body, Oxygen has been detected, but not quantified in, several different foods, such as epazotes, oval-leaf huckleberries, barley, alaska blueberries, and boysenberries. This could make oxygen a potential biomarker for the consumption of these foods. Oxygen is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

Value	Source
[OO]	ChEBI
Dioxygene	ChEBI
Disauerstoff	ChEBI
e 948	ChEBI
e-948	ChEBI
e948	ChEBI
Molecular oxygen	ChEBI
O2	ChEBI
OXYGEN molecule	ChEBI
Dioxygen	HMDB
Oxygen-16	HMDB
Oxygen 16	HMDB

Chemical Formula

O₂

Average Molecular Weight

32.0

Monoisotopic Molecular Weight

31.9898

IUPAC Name

dioxygen

Traditional Name

singlet oxygen

CAS Registry Number

7782-44-7

SMILES

O=O

InChI Identifier

InChI=1S/O2/c1-2

InChI Key

MYMOFIZGZYHOMD-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of inorganic compounds known as other non-metal oxides. These are inorganic compounds containing an oxygen atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen belongs to the class of 'other non-metals'.

Kingdom

Inorganic compounds

Super Class

Homogeneous non-metal compounds

Class

Other non-metal organides

Sub Class

Other non-metal oxides

Direct Parent

Other non-metal oxides

Alternative Parents

Inorganic oxides

Substituents

Other non-metal oxide
Inorganic oxide

Molecular Framework

Not Available

External Descriptors

diatomic oxygen (CHEBI:15379 )
elemental molecule (CHEBI:15379 )
a non-metabolic compound (OXYGEN-MOLECULE )

Ontology

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Plant:

Animal

Biological location:

Tissue and substructures:

All tissues

Biofluid and excreta:

Blood

Cell and elements:

Extracellular

Subcellular:

Role

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Physical Properties

State

Liquid

Experimental Properties

Property	Value	Reference
Melting Point	-218.4 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	37.5 mg/mL at 21 °C	Not Available
logP	0.65	HANSCH,C ET AL. (1995)

Predicted Properties

Property	Value	Source
logP	-0.28	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	34.14 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	2.89 m³·mol⁻¹	ChemAxon
Polarizability	1.53 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
Predicted GC-MS	Oxygen, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-001i-9000000000-2e78a9ed80eede2ed33a	Spectrum
Predicted GC-MS	Oxygen, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Oxygen, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-001i-9000000000-a9a93dd42f2cfa0b34c4	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-001i-9000000000-a9a93dd42f2cfa0b34c4	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-001i-9000000000-a9a93dd42f2cfa0b34c4	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-001i-9000000000-5e864878b295db174473	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-001i-9000000000-5e864878b295db174473	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-001i-9000000000-5e864878b295db174473	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-001i-9000000000-9878c3ba827de483e23b	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-001i-9000000000-9878c3ba827de483e23b	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-001i-9000000000-9878c3ba827de483e23b	2021-09-22	View Spectrum

NMR

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
D-Arginine and D-Ornithine Metabolism
Riboflavin Metabolism
Phenylalanine and Tyrosine Metabolism
Mitochondrial Electron Transport Chain
Ethanol Degradation		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Tyrosinase	TYR	11q14-q21	P14679	details
Peroxisomal sarcosine oxidase	PIPOX	17q11.2	Q9P0Z9	details
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	PAOX	10q26.3	Q6QHF9	details
Aldehyde oxidase	AOX1	2q33	Q06278	details
Lathosterol oxidase	SC5DL	11q23.3	O75845	details
Dimethylaniline monooxygenase [N-oxide-forming] 5	FMO5	1q21.1	P49326	details
Peroxisomal acyl-coenzyme A oxidase 1	ACOX1	17q25.1	Q15067	details
D-aspartate oxidase	DDO	6q21	Q99489	details
Heme oxygenase 2	HMOX2	16p13.3	P30519	details
Squalene monooxygenase	SQLE	8q24.1	Q14534	details
Dimethylaniline monooxygenase [N-oxide-forming] 2	FMO2	1q24.3	Q99518	details
Amine oxidase [flavin-containing] B	MAOB	Xp11.23	P27338	details
Dimethylaniline monooxygenase [N-oxide-forming] 4	FMO4	1q24.3	P31512	details
Amine oxidase [flavin-containing] A	MAOA	Xp11.3	P21397	details
Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	1q24.3	P31513	details
Xanthine dehydrogenase/oxidase	XDH	2p23.1	P47989	details
Dihydroorotate dehydrogenase (quinone), mitochondrial	DHODH	16q22	Q02127	details
Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	1q24.3	Q01740	details
Peroxisomal acyl-coenzyme A oxidase 3	ACOX3	4p15.3	O15254	details
Heme oxygenase 1	HMOX1	22q13.1	P09601	details
D-amino-acid oxidase	DAO	12q24	P14920	details
Coproporphyrinogen-III oxidase, mitochondrial	CPOX	3q12	P36551	details
Peptidyl-glycine alpha-amidating monooxygenase	PAM	5q14-q21	P19021	details
Dopamine beta-hydroxylase	DBH	9q34	P09172	details
Methylsterol monooxygenase 1	MSMO1	4q32-q34	Q15800	details
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	Xq28	Q15738	details
Lanosterol 14-alpha demethylase	CYP51A1	7q21.2	Q16850	details
Phytanoyl-CoA dioxygenase, peroxisomal	PHYH	10p13	O14832	details
Tyrosine 3-monooxygenase	TH	11p15.5	P07101	details
Phenylalanine-4-hydroxylase	PAH	12q22-q24.2	P00439	details
Peroxiredoxin-6	PRDX6	1q25.1	P30041	details
Prolyl 4-hydroxylase subunit alpha-2	P4HA2	5q31	O15460	details
Prolyl 4-hydroxylase subunit alpha-1	P4HA1	10q21.3-q23.1	P13674	details
Acyl-CoA desaturase	SCD	10q24.31	O00767	details
Gamma-butyrobetaine dioxygenase	BBOX1	11p14.2	O75936	details
Amiloride-sensitive amine oxidase [copper-containing]	ABP1	7q36.1	P19801	details
Membrane primary amine oxidase	AOC3	17q21	Q16853	details
Retina-specific copper amine oxidase	AOC2	17q21	O75106	details
Indoleamine 2,3-dioxygenase 1	IDO1	8p12-p11	P14902	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	1p36.22	Q02809	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	PLOD2	3q24	O00469	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	7q22	O60568	details
Tryptophan 5-hydroxylase 1	TPH1	11p15.3-p14	P17752	details
Tryptophan 5-hydroxylase 2	TPH2	12q21.1	Q8IWU9	details
Cholesterol 7-alpha-monooxygenase	CYP7A1	8q11-q12	P22680	details
Pyridoxine-5'-phosphate oxidase	PNPO	17q21.32	Q9NVS9	details
Protein-lysine 6-oxidase	LOX	5q23.2	P28300	details
Hydroxyacid oxidase 1	HAO1	20p12	Q9UJM8	details
Hydroxyacid oxidase 2	HAO2	1p13.3-p13.1	Q9NYQ3	details
Inositol oxygenase	MIOX	22q13.3	Q9UGB7	details
4-hydroxyphenylpyruvate dioxygenase	HPD	12q24-qter	P32754	details
Homogentisate 1,2-dioxygenase	HGD	3q13.33	Q93099	details
3-keto-steroid reductase	HSD17B7	1q23	P56937	details
Nitric oxide synthase, inducible	NOS2	17q11.2-q12	P35228	details
Nitric oxide synthase, brain	NOS1	12q24.2-q24.31	P29475	details
Nitric oxide synthase, endothelial	NOS3	7q36	P29474	details
Cysteine dioxygenase type 1	CDO1	5q23.2	Q16878	details
Arachidonate 5-lipoxygenase	ALOX5	10q11.2	P09917	details
Arachidonate 15-lipoxygenase B	ALOX15B	17p13.1	O15296	details
Arachidonate 12-lipoxygenase, 12S-type	ALOX12	17p13.1	P18054	details
Prostaglandin G/H synthase 2	PTGS2	1q25.2-q25.3	P35354	details
Prostaglandin G/H synthase 1	PTGS1	9q32-q33.3	P23219	details
Arachidonate 15-lipoxygenase	ALOX15	17p13.3	P16050	details
Leukotriene-B(4) omega-hydroxylase 1	CYP4F2	19p13.12	P78329	details
Leukotriene-B(4) omega-hydroxylase 2	CYP4F3	19p13.2	Q08477	details
Protoporphyrinogen oxidase	PPOX	1q22	P50336	details
Aspartyl/asparaginyl beta-hydroxylase	ASPH	8q12.1	Q12797	details
Sterol 26-hydroxylase, mitochondrial	CYP27A1	2q33-qter	Q02318	details
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	12q13.1-q13.3	O15528	details
Steroid 17-alpha-hydroxylase/17,20 lyase	CYP17A1	10q24.3	P05093	details
Sulfite oxidase, mitochondrial	SUOX	12q13.2	P51687	details
3-hydroxyanthranilate 3,4-dioxygenase	HAAO	2p21	P46952	details
Beta,beta-carotene 15,15'-monooxygenase	BCMO1	16q23.2	Q9HAY6	details
Catalase	CAT	11p13	P04040	details
25-hydroxycholesterol 7-alpha-hydroxylase	CYP7B1	8q21.3	O75881	details
Cytochrome c oxidase subunit 1	MT-CO1		P00395	details
Vitamin K-dependent gamma-carboxylase	GGCX	2p12	P38435	details
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	CYP24A1	20q13	Q07973	details
Putative dimethylaniline monooxygenase [N-oxide-forming] 6	FMO6P		O60774	details
Superoxide dismutase [Mn], mitochondrial	SOD2	6q25.3	P04179	details
Superoxide dismutase [Cu-Zn]	SOD1	21q22.11	P00441	details
Cytochrome c oxidase subunit 7A1, mitochondrial	COX7A1	19q13.1	P24310	details
Kynurenine 3-monooxygenase	KMO	1q42-q44	O15229	details
Spermine oxidase	SMOX	20p13	Q9NWM0	details
Vitamin D 25-hydroxylase	CYP2R1	11p15.2	Q6VVX0	details
Cytochrome c oxidase subunit 7A2, mitochondrial	COX7A2	6q12	P14406	details
Cholesterol 25-hydroxylase	CH25H	10q23	O95992	details
Dual oxidase 2	DUOX2	15q15.3	Q9NRD8	details
Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	16p	Q02221	details
Extracellular superoxide dismutase [Cu-Zn]	SOD3	4p15.2	P08294	details
Cytochrome c oxidase subunit 7B, mitochondrial	COX7B		P24311	details
Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	5q14	P15954	details
Cytochrome c oxidase subunit 5B, mitochondrial	COX5B	2cen-q13	P10606	details
Cytochrome c oxidase subunit 6B1	COX6B1	19q13.1	P14854	details
Cytochrome c oxidase subunit 7B2, mitochondrial	COX7B2	4p12	Q8TF08	details
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	16q24.1	P13073	details
Cytochrome c oxidase subunit 6B2	COX6B2	19q13.42	Q6YFQ2	details
Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	11q12-q13	P10176	details
Cytochrome c oxidase subunit 6C	COX6C	8q22.2	P09669	details
Cytochrome c oxidase subunit 7A-related protein, mitochondrial	COX7A2L	2p21	O14548	details
Cytochrome c oxidase subunit 8C, mitochondrial	COX8C	14q32.12	Q7Z4L0	details
Trimethyllysine dioxygenase, mitochondrial	TMLHE	Xq28	Q9NVH6	details
Cholesterol 24-hydroxylase	CYP46A1	14q32.1	Q9Y6A2	details
Tryptophan 2,3-dioxygenase	TDO2	4q31-q32	P48775	details
24-hydroxycholesterol 7-alpha-hydroxylase	CYP39A1	6p21.1-p11.2	Q9NYL5	details
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase	CYP8B1	3p22.1	Q9UNU6	details
Cytochrome c oxidase subunit 2	MT-CO2		P00403	details
Cytochrome c oxidase subunit 6A1, mitochondrial	COX6A1	12q24.2\|12q24.2	P12074	details
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial	COX4I2	20q11.21	Q96KJ9	details
Dual oxidase 1	DUOX1	15q15.3	Q9NRD9	details
Stearoyl-CoA desaturase 5	SCD5	4q21.22	Q86SK9	details
Putative uncharacterized protein DKFZp686B0215	DKFZp686B0215		Q5HYI4	details
Indoleamine 2,3-dioxygenase 2	IDO2	8p11.21	Q6ZQW0	details
Cytochrome P450, family 1, subfamily A, polypeptide 1	CYP1A1	15q24.1	A0N0X8	details
Ubiquinone biosynthesis monooxygenase COQ6	COQ6		Q9Y2Z9	details
Lysyl oxidase homolog 2	LOXL2	8p21.3	Q9Y4K0	details
FAD-linked sulfhydryl oxidase ALR	GFER	16p13.3-p13.12	P55789	details
Protein-methionine sulfoxide oxidase MICAL1	MICAL1	6q21	Q8TDZ2	details
Protein-methionine sulfoxide oxidase MICAL2	MICAL2	11p15.3	O94851	details
Protein-methionine sulfoxide oxidase MICAL3	MICAL3	22q11.21	Q7RTP6	details
L-amino-acid oxidase	IL4I1	19q13.3-q13.4	Q96RQ9	details
Prenylcysteine oxidase 1	PCYOX1	2p13.3	Q9UHG3	details
Sulfhydryl oxidase 1	QSOX1	1q24	O00391	details
Sulfhydryl oxidase 2	QSOX2	9q34.3	Q6ZRP7	details
2-aminoethanethiol dioxygenase	ADO	10q21.3	Q96SZ5	details
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2	ALKBH2	12q24.11	Q6NS38	details
Beta,beta-carotene 9',10'-oxygenase	BCO2	11q23.1	Q9BYV7	details
Prolyl 3-hydroxylase 1	LEPRE1	1p34.1	Q32P28	details
Prolyl 3-hydroxylase 2	LEPREL1	3q28	Q8IVL5	details
Prolyl 3-hydroxylase 3	LEPREL2	12q13	Q8IVL6	details
Prolyl 4-hydroxylase subunit alpha-3	P4HA3	11q13.4	Q7Z4N8	details
Lysine-specific demethylase 2A	KDM2A	11q13.2	Q9Y2K7	details
Lysine-specific demethylase 2B	KDM2B	12q24.31	Q8NHM5	details
Deoxyhypusine hydroxylase	DOHH	19p13.3	Q9BU89	details
Egl nine homolog 1	EGLN1	1q42.1	Q9GZT9	details
Egl nine homolog 2	EGLN2	19q13.2	Q96KS0	details
Egl nine homolog 3	EGLN3	14q13.1	Q9H6Z9	details
Transmembrane prolyl 4-hydroxylase	P4HTM	3p21.3	Q9NXG6	details
Cytochrome P450, family 21, subfamily A, polypeptide 2	CYP21A2	6p21.3	Q08AG9	details
CP protein	CP	3q23-q25	A5PL27	details
NOS1 mutant	NOS1	12q24.2-q24.31	B3VK56	details
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase	ADI1	2p25.3	Q9BV57	details
Alkylglycerol monooxygenase	AGMO	7p21.2	Q6ZNB7	details
Steroid 21-hydroxylase	CYP21A2	6p21.3	P08686	details
Lysine-specific demethylase 8	KDM8	16p12.1	Q8N371	details
Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA	MINA	3q11.2	Q8IUF8	details
Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66	NO66	14q24.3	Q9H6W3	details
Histone lysine demethylase PHF8	PHF8	Xp11.22	Q9UPP1	details
Methylcytosine dioxygenase TET1	TET1	10q21	Q8NFU7	details
Methylcytosine dioxygenase TET2	TET2	4q24	Q6N021	details
Methylcytosine dioxygenase TET3	TET3	2p13.1	O43151	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Nitric oxide synthase, inducible	NOS2	17q11.2-q12	P35228	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Aldehyde oxidase	AOX1	2q33	Q06278	details
Lathosterol oxidase	SC5DL	11q23.3	O75845	details
Heme oxygenase 2	HMOX2	16p13.3	P30519	details
Xanthine dehydrogenase/oxidase	XDH	2p23.1	P47989	details
Heme oxygenase 1	HMOX1	22q13.1	P09601	details
Peptidyl-glycine alpha-amidating monooxygenase	PAM	5q14-q21	P19021	details
Dopamine beta-hydroxylase	DBH	9q34	P09172	details
Methylsterol monooxygenase 1	MSMO1	4q32-q34	Q15800	details
Lanosterol 14-alpha demethylase	CYP51A1	7q21.2	Q16850	details
Phytanoyl-CoA dioxygenase, peroxisomal	PHYH	10p13	O14832	details
Tyrosine 3-monooxygenase	TH	11p15.5	P07101	details
Phenylalanine-4-hydroxylase	PAH	12q22-q24.2	P00439	details
Prolyl 4-hydroxylase subunit alpha-2	P4HA2	5q31	O15460	details
Prolyl 4-hydroxylase subunit alpha-1	P4HA1	10q21.3-q23.1	P13674	details
Acyl-CoA desaturase	SCD	10q24.31	O00767	details
Gamma-butyrobetaine dioxygenase	BBOX1	11p14.2	O75936	details
Amiloride-sensitive amine oxidase [copper-containing]	ABP1	7q36.1	P19801	details
Membrane primary amine oxidase	AOC3	17q21	Q16853	details
Retina-specific copper amine oxidase	AOC2	17q21	O75106	details
Cytochrome P450 4A11	CYP4A11	1p33	Q02928	details
Indoleamine 2,3-dioxygenase 1	IDO1	8p12-p11	P14902	details
Cytochrome P450 11B1, mitochondrial	CYP11B1	8q21	P15538	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	1p36.22	Q02809	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	PLOD2	3q24	O00469	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	7q22	O60568	details
Tryptophan 5-hydroxylase 1	TPH1	11p15.3-p14	P17752	details
Ferritin, mitochondrial	FTMT	5q21.3	Q8N4E7	details
Tryptophan 5-hydroxylase 2	TPH2	12q21.1	Q8IWU9	details
Ceruloplasmin	CP	3q23-q25	P00450	details
Cholesterol 7-alpha-monooxygenase	CYP7A1	8q11-q12	P22680	details
Protein-lysine 6-oxidase	LOX	5q23.2	P28300	details
Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	15q23-q24	P05108	details
Inositol oxygenase	MIOX	22q13.3	Q9UGB7	details
4-hydroxyphenylpyruvate dioxygenase	HPD	12q24-qter	P32754	details
Homogentisate 1,2-dioxygenase	HGD	3q13.33	Q93099	details
Nitric oxide synthase, inducible	NOS2	17q11.2-q12	P35228	details
Nitric oxide synthase, brain	NOS1	12q24.2-q24.31	P29475	details
Nitric oxide synthase, endothelial	NOS3	7q36	P29474	details
Cysteine dioxygenase type 1	CDO1	5q23.2	Q16878	details
Arachidonate 5-lipoxygenase	ALOX5	10q11.2	P09917	details
Arachidonate 15-lipoxygenase B	ALOX15B	17p13.1	O15296	details
Arachidonate 12-lipoxygenase, 12S-type	ALOX12	17p13.1	P18054	details
Prostaglandin G/H synthase 2	PTGS2	1q25.2-q25.3	P35354	details
Prostaglandin G/H synthase 1	PTGS1	9q32-q33.3	P23219	details
Arachidonate 15-lipoxygenase	ALOX15	17p13.3	P16050	details
Leukotriene-B(4) omega-hydroxylase 1	CYP4F2	19p13.12	P78329	details
Leukotriene-B(4) omega-hydroxylase 2	CYP4F3	19p13.2	Q08477	details
Cytochrome P450 3A4	CYP3A4	7q21.1	P08684	details
Cytochrome P450 2C9	CYP2C9	10q24	P11712	details
Sterol 26-hydroxylase, mitochondrial	CYP27A1	2q33-qter	Q02318	details
Cytochrome P450 2C19	CYP2C19	10q24	P33261	details
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	12q13.1-q13.3	O15528	details
Steroid 17-alpha-hydroxylase/17,20 lyase	CYP17A1	10q24.3	P05093	details
Sulfite oxidase, mitochondrial	SUOX	12q13.2	P51687	details
3-hydroxyanthranilate 3,4-dioxygenase	HAAO	2p21	P46952	details
Cytochrome P450 2E1	CYP2E1	10q24.3-qter	P05181	details
Cytochrome P450 4F11	CYP4F11	19p13.1	Q9HBI6	details
Cytochrome P450 3A43	CYP3A43	7q21.1	Q9HB55	details
Cytochrome P450 1B1	CYP1B1	2p22.2	Q16678	details
Cytochrome P450 2D6	CYP2D6	22q13.1	P10635	details
Cytochrome P450 2C18	CYP2C18	10q24	P33260	details
Cytochrome P450 4F12	CYP4F12	19p13.1	Q9HCS2	details
Cytochrome P450 2F1	CYP2F1	19q13.2	P24903	details
Cytochrome P450 4X1	CYP4X1	1	Q8N118	details
Cytochrome P450 2B6	CYP2B6	19q13.2	P20813	details
Cytochrome P450 3A5	CYP3A5	7q21.1	P20815	details
Cytochrome P450 1A1	CYP1A1	15q24.1	P04798	details
Cytochrome P450 2A13	CYP2A13	19q13.2	Q16696	details
Cytochrome P450 3A7	CYP3A7	7q21-q22.1	P24462	details
Cytochrome P450 4B1	CYP4B1	1p34-p12	P13584	details
Cytochrome P450 4Z1	CYP4Z1	1p33	Q86W10	details
Cytochrome P450 1A2	CYP1A2	15q24.1	P05177	details
Cytochrome P450 19A1	CYP19A1	15q21.1	P11511	details
Cytochrome P450 2C8	CYP2C8	10q23.33	P10632	details
Cytochrome P450 2S1	CYP2S1	19q13.1	Q96SQ9	details
Cytochrome P450 4F8	CYP4F8	19p13.1	P98187	details
Cytochrome P450 2J2	CYP2J2	1p31.3-p31.2	P51589	details
Cytochrome P450 2A7	CYP2A7	19q13.2	P20853	details
Cytochrome P450 2A6	CYP2A6	19q13.2	P11509	details
Beta,beta-carotene 15,15'-monooxygenase	BCMO1	16q23.2	Q9HAY6	details
Catalase	CAT	11p13	P04040	details
Hemoglobin subunit beta	HBB	11p15.5	P68871	details
Hemoglobin subunit alpha	HBA1	16p13.3	P69905	details
25-hydroxycholesterol 7-alpha-hydroxylase	CYP7B1	8q21.3	O75881	details
Cytochrome c oxidase subunit 1	MT-CO1		P00395	details
Ubiquinone biosynthesis protein COQ7 homolog	COQ7		Q99807	details
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	CYP24A1	20q13	Q07973	details
Superoxide dismutase [Mn], mitochondrial	SOD2	6q25.3	P04179	details
Superoxide dismutase [Cu-Zn]	SOD1	21q22.11	P00441	details
Myoglobin	MB	22q13.1	P02144	details
Vitamin D 25-hydroxylase	CYP2R1	11p15.2	Q6VVX0	details
Hemoglobin subunit gamma-2	HBG2	11p15.5	P69892	details
Cholesterol 25-hydroxylase	CH25H	10q23	O95992	details
Dual oxidase 2	DUOX2	15q15.3	Q9NRD8	details
Extracellular superoxide dismutase [Cu-Zn]	SOD3	4p15.2	P08294	details
Trimethyllysine dioxygenase, mitochondrial	TMLHE	Xq28	Q9NVH6	details
Cholesterol 24-hydroxylase	CYP46A1	14q32.1	Q9Y6A2	details
Cytochrome P450 11B2, mitochondrial	CYP11B2	8q21-q22	P19099	details
Tryptophan 2,3-dioxygenase	TDO2	4q31-q32	P48775	details
24-hydroxycholesterol 7-alpha-hydroxylase	CYP39A1	6p21.1-p11.2	Q9NYL5	details
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase	CYP8B1	3p22.1	Q9UNU6	details
Cytochrome c oxidase subunit 2	MT-CO2		P00403	details
Dual oxidase 1	DUOX1	15q15.3	Q9NRD9	details
Cytochrome P450 4A22	CYP4A22	1p33	Q5TCH4	details
Stearoyl-CoA desaturase 5	SCD5	4q21.22	Q86SK9	details
Indoleamine 2,3-dioxygenase 2	IDO2	8p11.21	Q6ZQW0	details
Cytochrome P450, family 1, subfamily A, polypeptide 1	CYP1A1	15q24.1	A0N0X8	details
Lysyl oxidase homolog 2	LOXL2	8p21.3	Q9Y4K0	details
Protein-methionine sulfoxide oxidase MICAL1	MICAL1	6q21	Q8TDZ2	details
Protein-methionine sulfoxide oxidase MICAL2	MICAL2	11p15.3	O94851	details
Protein-methionine sulfoxide oxidase MICAL3	MICAL3	22q11.21	Q7RTP6	details
Cytochrome P450 20A1	CYP20A1	2q33.2	Q6UW02	details
Cytochrome P450 2U1	CYP2U1	4q25	Q7Z449	details
Cytochrome P450 4F22	CYP4F22		Q6NT55	details
Cytoglobin	CYGB	17q25.3	Q8WWM9	details
Hemoglobin subunit delta	HBD	11p15.5	P02042	details
Neuroglobin	NGB	14q24.3	Q9NPG2	details
2-aminoethanethiol dioxygenase	ADO	10q21.3	Q96SZ5	details
Beta,beta-carotene 9',10'-oxygenase	BCO2	11q23.1	Q9BYV7	details
Ferritin heavy chain	FTH1	11q13	P02794	details
Prolyl 3-hydroxylase 1	LEPRE1	1p34.1	Q32P28	details
Prolyl 3-hydroxylase 2	LEPREL1	3q28	Q8IVL5	details
Prolyl 3-hydroxylase 3	LEPREL2	12q13	Q8IVL6	details
Prolyl 4-hydroxylase subunit alpha-3	P4HA3	11q13.4	Q7Z4N8	details
Lysine-specific demethylase 2A	KDM2A	11q13.2	Q9Y2K7	details
Lysine-specific demethylase 2B	KDM2B	12q24.31	Q8NHM5	details
Deoxyhypusine hydroxylase	DOHH	19p13.3	Q9BU89	details
Egl nine homolog 1	EGLN1	1q42.1	Q9GZT9	details
Egl nine homolog 2	EGLN2	19q13.2	Q96KS0	details
Egl nine homolog 3	EGLN3	14q13.1	Q9H6Z9	details
Transmembrane prolyl 4-hydroxylase	P4HTM	3p21.3	Q9NXG6	details
Cytochrome P450, family 21, subfamily A, polypeptide 2	CYP21A2	6p21.3	Q08AG9	details
CP protein	CP	3q23-q25	A5PL27	details
NOS1 mutant	NOS1	12q24.2-q24.31	B3VK56	details
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase	ADI1	2p25.3	Q9BV57	details
Lysine-specific demethylase 8	KDM8	16p12.1	Q8N371	details
Pirin	PIR	Xp22.2	O00625	details
Methylcytosine dioxygenase TET2	TET2	4q24	Q6N021	details
Methylcytosine dioxygenase TET3	TET3	2p13.1	O43151	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Tyrosine 3-monooxygenase	TH	11p15.5	P07101	details
Amiloride-sensitive amine oxidase [copper-containing]	ABP1	7q36.1	P19801	details
Nitric oxide synthase, brain	NOS1	12q24.2-q24.31	P29475	details
Prostaglandin G/H synthase 1	PTGS1	9q32-q33.3	P23219	details
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	12q13.1-q13.3	O15528	details
25-hydroxycholesterol 7-alpha-hydroxylase	CYP7B1	8q21.3	O75881	details
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	CYP24A1	20q13	Q07973	details
Superoxide dismutase [Cu-Zn]	SOD1	21q22.11	P00441	details
Lysyl oxidase homolog 2	LOXL2	8p21.3	Q9Y4K0	details
Egl nine homolog 2	EGLN2	19q13.2	Q96KS0	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Heme oxygenase 1	HMOX1	22q13.1	P09601	details
Nitric oxide synthase, brain	NOS1	12q24.2-q24.31	P29475	details
Aspartyl/asparaginyl beta-hydroxylase	ASPH	8q12.1	Q12797	details
Hypoxia-inducible factor 1-alpha inhibitor	HIF1AN	10q24	Q9NWT6	details
Catalase	CAT	11p13	P04040	details
Superoxide dismutase [Mn], mitochondrial	SOD2	6q25.3	P04179	details
Lysyl oxidase homolog 2	LOXL2	8p21.3	Q9Y4K0	details
Lysine-specific demethylase 2A	KDM2A	11q13.2	Q9Y2K7	details
Lysine-specific demethylase 2B	KDM2B	12q24.31	Q8NHM5	details
Egl nine homolog 1	EGLN1	1q42.1	Q9GZT9	details
Egl nine homolog 2	EGLN2	19q13.2	Q96KS0	details
Egl nine homolog 3	EGLN3	14q13.1	Q9H6Z9	details
Lysine-specific demethylase 8	KDM8	16p12.1	Q8N371	details
Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66	NO66	14q24.3	Q9H6W3	details
Histone lysine demethylase PHF8	PHF8	Xp11.22	Q9UPP1	details
Pirin	PIR	Xp22.2	O00625	details
Methylcytosine dioxygenase TET1	TET1	10q21	Q8NFU7	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0001377

DrugBank ID

DB09140

Phenol Explorer Compound ID

Not Available

FoodDB ID

FDB022589

KNApSAcK ID

Not Available

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

PDB ID

Not Available

ChEBI ID

15379

References

General References

Not Available

Only showing the first 10 proteins. There are 318 proteins in total.

Show All

Enzymes

Enzyme Details

1. Tyrosinase

General function:: Involved in oxidoreductase activity
Specific function:: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
Gene Name:: TYR
Uniprot ID:: P14679
Molecular weight:: 60392.69

Enzyme Details

2. Peroxisomal sarcosine oxidase

General function:: Involved in oxidoreductase activity
Specific function:: Metabolizes sarcosine, L-pipecolic acid and L-proline.
Gene Name:: PIPOX
Uniprot ID:: Q9P0Z9
Molecular weight:: 44065.515

Enzyme Details

3. Peroxisomal N(1)-acetyl-spermine/spermidine oxidase

General function:: Amino acid transport and metabolism
Specific function:: Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.
Gene Name:: PAOX
Uniprot ID:: Q6QHF9
Molecular weight:: 55512.64

Enzyme Details

4. Aldehyde oxidase

General function:: Involved in oxidoreductase activity
Specific function:: Not Available
Gene Name:: AOX1
Uniprot ID:: Q06278
Molecular weight:: 147916.735

Enzyme Details

5. Lathosterol oxidase

General function:: Involved in iron ion binding
Specific function:: Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol.
Gene Name:: SC5DL
Uniprot ID:: O75845
Molecular weight:: 35300.55

Enzyme Details

6. Dimethylaniline monooxygenase [N-oxide-forming] 5

General function:: Involved in flavin-containing monooxygenase activity
Specific function:: In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.
Gene Name:: FMO5
Uniprot ID:: P49326
Molecular weight:: 32480.04

Enzyme Details

7. Peroxisomal acyl-coenzyme A oxidase 1

General function:: Involved in acyl-CoA dehydrogenase activity
Specific function:: Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA.
Gene Name:: ACOX1
Uniprot ID:: Q15067
Molecular weight:: 70135.205

Enzyme Details

8. D-aspartate oxidase

General function:: Involved in D-amino-acid oxidase activity
Specific function:: Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate.
Gene Name:: DDO
Uniprot ID:: Q99489
Molecular weight:: 40992.53

Enzyme Details

9. Heme oxygenase 2

General function:: Involved in heme oxygenase (decyclizing) activity
Specific function:: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.
Gene Name:: HMOX2
Uniprot ID:: P30519
Molecular weight:: 36032.615

Enzyme Details

10. Squalene monooxygenase

General function:: Involved in oxidoreductase activity
Specific function:: Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.
Gene Name:: SQLE
Uniprot ID:: Q14534
Molecular weight:: 63922.505

Transporters

Enzyme Details

1. Nitric oxide synthase, inducible

General function:: Involved in oxidoreductase activity
Specific function:: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
Gene Name:: NOS2
Uniprot ID:: P35228
Molecular weight:: 131116.3

Only showing the first 10 proteins. There are 318 proteins in total.

Show All

Showing Compound Card for Oxygen (CDB004910)

Structure for CDB004910 (Oxygen)

Enzymes

Transporters