Cannabis Compound Database: Showing Protein Cytochrome P450 2D6 (CDBP01436)

Identification Biological properties Gene properties Protein properties External links References XML Show 10 compounds

Identification

HMDB Protein ID

CDBP01436

Secondary Accession Numbers

Not Available

Name

Cytochrome P450 2D6

Description

Not Available

Synonyms

CYPIID6
Cytochrome P450-DB1
Debrisoquine 4-hydroxylase

Gene Name

CYP2D6

Protein Type

Metal Binding

Biological Properties

General Function

Involved in monooxygenase activity

Specific Function

Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.

GO Classification

Biological Process
isoquinoline alkaloid metabolic process
negative regulation of binding
negative regulation of cellular organofluorine metabolic process
dopamine metabolic process
small molecule metabolic process
oxidative demethylation
coumarin metabolic process
response to organic substance
monoterpenoid metabolic process
steroid metabolic process
xenobiotic metabolic process
alkaloid catabolic process
arachidonic acid metabolic process
drug catabolic process
Cellular Component
endoplasmic reticulum membrane
mitochondrion
Function
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
oxidoreductase activity
ion binding
cation binding
metal ion binding
binding
catalytic activity
transition metal ion binding
electron carrier activity
iron ion binding
monooxygenase activity
heme binding
Molecular Function
electron carrier activity
monooxygenase activity
aromatase activity
iron ion binding
steroid 21-monooxygenase activity
heme binding
arachidonic acid monooxygenase activity
drug binding
Process
metabolic process
oxidation reduction

Cellular Location

Peripheral membrane protein
Peripheral membrane protein
Endoplasmic reticulum membrane
Microsome membrane

Pathways

Name	SMPDB/Pathwhiz	KEGG
Metabolism of xenobiotics by cytochrome P450	Not Available
Drug metabolism - cytochrome P450	Not Available
Serotonergic synapse	Not Available
Methadone Action Pathway		Not Available
Methadone Metabolism Pathway		Not Available

Gene Properties

Chromosome Location

Locus

22q13.1

SNPs

CYP2D6

Gene Sequence

>1494 bp
ATGGGGCTAGAAGCACTGGTGCCCCTGGCCGTGATAGTGGCCATCTTCCTGCTCCTGGTG
GACCTGATGCACCGGCGCCAACGCTGGGCTGCACGCTACCCACCAGGCCCCCTGCCACTG
CCCGGGCTGGGCAACCTGCTGCATGTGGACTTCCAGAACACACCATACTGCTTCGACCAG
TTGCGGCGCCGCTTCGGGGACGTGTTCAGCCTGCAGCTGGCCTGGACGCCGGTGGTCGTG
CTCAATGGGCTGGCGGCCGTGCGCGAGGCGCTGGTGACCCACGGCGAGGACACCGCCGAC
CGCCCGCCTGTGCCCATCACCCAGATCCTGGGTTTCGGGCCGCGTTCCCAAGGGGTGTTC
CTGGCGCGCTATGGGCCCGCGTGGCGCGAGCAGAGGCGCTTCTCCGTGTCCACCTTGCGC
AACTTGGGCCTGGGCAAGAAGTCGCTGGAGCAGTGGGTGACCGAGGAGGCCGCCTGCCTT
TGTGCCGCCTTCGCCAACCACTCCGGACGCCCCTTTCGCCCCAACGGTCTCTTGGACAAA
GCCGTGAGCAACGTGATCGCCTCCCTCACCTGCGGGCGCCGCTTCGAGTACGACGACCCT
CGCTTCCTCAGGCTGCTGGACCTAGCTCAGGAGGGACTGAAGGAGGAGTCGGGCTTTCTG
CGCGAGGTGCTGAATGCTGTCCCCGTCCTCCTGCATATCCCAGCGCTGGCTGGCAAGGTC
CTACGCTTCCAAAAGGCTTTCCTGACCCAGCTGGATGAGCTGCTAACTGAGCACAGGATG
ACCTGGGACCCAGCCCAGCCCCCCCGAGACCTGACTGAGGCCTTCCTGGCAGAGATGGAG
AAGGCCAAGGGGAACCCTGAGAGCAGCTTCAATGATGAGAACCTGCGCATAGTGGTGGCT
GACCTGTTCTCTGCCGGGATGGTGACCACCTCGACCACGCTGGCCTGGGGCCTCCTGCTC
ATGATCCTACATCCGGATGTGCAGCGCCGTGTCCAACAGGAGATCGACGACGTGATAGGG
CAGGTGCGGCGACCAGAGATGGGTGACCAGGCTCACATGCCCTACACCACTGCCGTGATT
CATGAGGTGCAGCGCTTTGGGGACATCGTCCCCCTGGGTGTGACCCATATGACATCCCGT
GACATCGAAGTACAGGGCTTCCGCATCCCTAAGGGAACGACACTCATCACCAACCTGTCA
TCGGTGCTGAAGGATGAGGCCGTCTGGGAGAAGCCCTTCCGCTTCCACCCCGAACACTTC
CTGGATGCCCAGGGCCACTTTGTGAAGCCGGAGGCCTTCCTGCCTTTCTCAGCAGGCCGC
CGTGCATGCCTCGGGGAGCCCCTGGCCCGCATGGAGCTCTTCCTCTTCTTCACCTCCCTG
CTGCAGCACTTCAGCTTCTCGGTGCCCACTGGACAGCCCCGGCCCAGCCACCATGGTGTC
TTTGCTTTCCTGGTGAGCCCATCCCCCTATGAGCTTTGTGCTGTGCCCCGCTAG

Protein Properties

Number of Residues

497

Molecular Weight

55768.94

Theoretical pI

7.248

Pfam Domain Function

p450 (PF00067 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Cytochrome P450 2D6
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR

External Links

GenBank ID Protein

45024928

UniProtKB/Swiss-Prot ID

P10635

UniProtKB/Swiss-Prot Entry Name

CP2D6_HUMAN

PDB IDs