Identification |
HMDB Protein ID
| CDBP02462 |
Secondary Accession Numbers
| Not Available |
Name
| 24-hydroxycholesterol 7-alpha-hydroxylase |
Description
| Not Available |
Synonyms
|
- Cytochrome P450 39A1
- Oxysterol 7-alpha-hydroxylase
- hCYP39A1
|
Gene Name
| CYP39A1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in monooxygenase activity |
Specific Function
| Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha-hydroxylated product.
|
GO Classification
|
Biological Process |
bile acid biosynthetic process |
digestion |
xenobiotic metabolic process |
bile acid catabolic process |
cholesterol catabolic process |
Cellular Component |
endoplasmic reticulum membrane |
Function |
heme binding |
oxidoreductase activity |
ion binding |
cation binding |
metal ion binding |
binding |
catalytic activity |
transition metal ion binding |
electron carrier activity |
iron ion binding |
monooxygenase activity |
Molecular Function |
electron carrier activity |
iron ion binding |
heme binding |
24-hydroxycholesterol 7alpha-hydroxylase activity |
oxysterol 7-alpha-hydroxylase activity |
steroid 7-alpha-hydroxylase activity |
|
Cellular Location
|
- Peripheral membrane protein
- Peripheral membrane protein
- Endoplasmic reticulum membrane
- Microsome membrane
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Bile Acid Biosynthesis | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000145/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000145/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000145/thumb?image_type=simple) | ![Map00120](https://www.genome.jp/kegg/misc/thumbnail/map00120.gif) | Primary bile acid biosynthesis | Not Available | ![Map00120](https://www.genome.jp/kegg/misc/thumbnail/map00120.gif) | Congenital Bile Acid Synthesis Defect Type II | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000192/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000192/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000192/thumb?image_type=simple) | Not Available | Congenital Bile Acid Synthesis Defect Type III | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000193/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000193/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000193/thumb?image_type=simple) | Not Available | Familial Hypercholanemia (FHCA) | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000194/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000194/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000194/thumb?image_type=simple) | Not Available |
|
Gene Properties |
Chromosome Location
| 6 |
Locus
| 6p21.1-p11.2 |
SNPs
| CYP39A1 |
Gene Sequence
|
>1410 bp
ATGGAACTAATTTCCCCAACAGTGATTATAATCCTGGGTTGCCTTGCTCTGTTCTTACTC
CTTCAGCGGAAGAATTTGCGTAGACCCCCGTGCATCAAGGGCTGGATTCCTTGGATTGGA
GTTGGATTTGAGTTTGGGAAAGCCCCTCTAGAATTTATAGAGAAAGCAAGAATCAAGTAT
GGACCAATATTTACAGTCTTTGCTATGGGAAACCGAATGACCTTTGTTACTGAAGAAGAA
GGAATTAATGTGTTTCTAAAATCCAAAAAAGTAGATTTTGAACTAGCAGTGCAAAATATC
GTTTATCGTACAGCATCAATTCCAAAGAATGTCTTTTTAGCACTGCATGAAAAACTCTAT
ATTATGTTGAAAGGGAAAATGGGGACTGTCAATCTCCATCAGTTTACTGGGCAACTGACT
GAAGAATTACATGAACAACTGGAGAATTTAGGCACTCATGGGACAATGGACCTGAACAAC
TTAGTAAGACATCTCCTTTATCCAGTCACAGTGAATATGCTCTTTAATAAAAGTTTGTTT
TCCACAAACAAGAAAAAAATCAAGGAGTTCCATCAGTATTTTCAAGTTTATGATGAAGAT
TTTGAGTATGGGTCCCAGTTGCCAGAGTGTCTTCTAAGAAACTGGTCAAAATCCAAAAAG
TGGTTCCTGGAACTGTTTGAGAAAAACATTCCAGATATAAAAGCATGTAAATCTGCAAAA
GATAATTCCATGACATTATTGCAAGCTACGCTGGATATTGTAGAGACGGAAACAAGTAAG
GAAAACTCACCCAATTATGGGCTCTTACTGCTTTGGGCTTCTCTGTCTAATGCTGTTCCT
GTTGCATTTTGGACACTTGCATACGTCCTTTCTCATCCTGATATCCACAAGGCCATTATG
GAAGGCATATCTTCTGTGTTTGGCAAAGCAGGCAAAGATAAGATTAAAGTGTCTGAGGAT
GACCTGGAGAAACTCCTTCTAATTAAATGGTGTGTTTTGGAAACCATTCGTTTAAAAGCT
CCTGGTGTCATTACTAGAAAAGTGGTGAAGCCTGTGGAAATTTTGAATTACATCATTCCT
TCTGGTGACTTGTTGATGTTGTCTCCATTTTGGCTGCATAGAAATCCAAAGTATTTTCCT
GAGCCTGAATTGTTCAAACCTGAACGTTGGAAAAAGGCAAATTTAGAGAAGCACTCTTTC
TTGGACTGCTTCATGGCATTTGGAAGCGGGAAGTTCCAGTGTCCTGCAAGGTGGTTTGCT
CTGTTAGAGGTTCAGATGTGTATTATTTTAATACTTTATAAATATGACTGTAGTCTTCTG
GACCCATTACCCAAACAGAGTTATCTCCATTTGGTGGGTGTCCCCCAGCCGGAAGGGCAA
TGCCGAATTGAATATAAACAAAGAATATGA
|
Protein Properties |
Number of Residues
| 469 |
Molecular Weight
| 54115.29 |
Theoretical pI
| 8.643 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>24-hydroxycholesterol 7-alpha-hydroxylase
MELISPTVIIILGCLALFLLLQRKNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIKY
GPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVYRTASIPKNVFLALHEKLY
IMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLF
STNKKKIKEFHQYFQVYDEDFEYGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAK
DNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPVAFWTLAYVLSHPDIHKAIM
EGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIP
SGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFA
LLEVQMCIILILYKYDCSLLDPLPKQSYLHLVGVPQPEGQCRIEYKQRI
|
External Links |
GenBank ID Protein
| 7533024 |
UniProtKB/Swiss-Prot ID
| Q9NYL5 |
UniProtKB/Swiss-Prot Entry Name
| CP39A_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AF237982 |
GeneCard ID
| CYP39A1 |
GenAtlas ID
| CYP39A1 |
HGNC ID
| HGNC:17449 |
References |
General References
| Not Available |