Cannabis Compound Database: Showing Protein 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (CDBP04691)

Identification Biological properties Gene properties Protein properties External links References XML Show 6 compounds

Identification

HMDB Protein ID

CDBP04691

Secondary Accession Numbers

Not Available

Name

1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase

Description

Not Available

Synonyms

ARD
Aci-reductone dioxygenase
MTCBP-1
Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1
SIPL
Submergence-induced protein 2 homolog
Acireductone dioxygenase (Fe(2+)-requiring)
Submergence-induced protein-like factor
Fe-ARD
Sip-L

Gene Name

ADI1

Protein Type

Enzyme

Biological Properties

General Function

Involved in metal ion binding

Specific Function

Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.

GO Classification

Biological Process
L-methionine salvage from methylthioadenosine
polyamine metabolic process
Cellular Component
cytosol
plasma membrane
Golgi apparatus
nucleus
Function
dioxygenase activity
oxidoreductase activity
ion binding
cation binding
metal ion binding
binding
catalytic activity
Molecular Function
metal ion binding
acireductone dioxygenase [iron(II)-requiring] activity
Process
cellular amino acid biosynthetic process
metabolic process
cellular metabolic process
amino acid salvage
l-methionine salvage from methylthioadenosine
oxidation reduction
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process

Cellular Location

Cell membrane
Nucleus
Peripheral membrane protein
Cytoplasmic side

Pathways

Name	SMPDB/Pathwhiz	KEGG
L-methionine biosynthesis via salvage pathway	Not Available	Not Available
Cysteine and methionine metabolism	Not Available

Gene Properties

Chromosome Location

Locus

2p25.3

SNPs

ADI1

Gene Sequence

>540 bp
ATGGTGCAGGCCTGGTATATGGACGACGCCCCGGGCGACCCGCGGCAACCCCACCGCCCC
GACCCCGGCCGCCCAGTGGGCCTGGAGCAGCTGCGGCGGCTCGGGGTGCTCTACTGGAAG
CTGGATGCTGACAAATATGAGAATGATCCAGAATTAGAAAAGATCCGAAGAGAGAGGAAC
TACTCCTGGATGGACATCATAACCATATGCAAAGATAAACTACCAAATTATGAAGAAAAG
ATTAAGATGTTCTACGAGGAGCATTTGCACTTGGACGATGAGATCCGCTACATCCTGGAT
GGCAGTGGGTACTTCGACGTGAGGGACAAGGAGGACCAGTGGATCCGGATCTTCATGGAG
AAGGGAGACATGGTGACGCTCCCCGCGGGGATCTATCACCGCTTCACGGTGGACGAGAAG
AACTACACGAAGGCCATGCGGCTGTTTGTGGGAGAACCGGTGTGGACAGCGTACAACCGG
CCCGCTGACCATTTTGAAGCCCGCGGGCAGTACGTGAAATTTCTGGCACAGACCGCCTAG

Protein Properties

Number of Residues

179

Molecular Weight

21498.23

Theoretical pI

5.677

Pfam Domain Function

ARD (PF03079 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
MVQAWYMDDAPGDPRQPHRPDPGRPVGLEQLRRLGVLYWKLDADKYENDPELEKIRRERN
YSWMDIITICKDKLPNYEEKIKMFYEEHLHLDDEIRYILDGSGYFDVRDKEDQWIRIFME
KGDMVTLPAGIYHRFTVDEKNYTKAMRLFVGEPVWTAYNRPADHFEARGQYVKFLAQTA

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

Q9BV57

UniProtKB/Swiss-Prot Entry Name

MTND_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AB158319

GeneCard ID