Identification |
HMDB Protein ID
| CDBP01470 |
Secondary Accession Numbers
| Not Available |
Name
| Catalase |
Description
| Not Available |
Synonyms
|
Not Available
|
Gene Name
| CAT |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in catalase activity |
Specific Function
| Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.
|
GO Classification
|
Biological Process |
hemoglobin metabolic process |
hydrogen peroxide catabolic process |
menopause |
positive regulation of cell division |
positive regulation of NF-kappaB transcription factor activity |
positive regulation of phosphatidylinositol 3-kinase cascade |
response to hyperoxia |
triglyceride metabolic process |
UV protection |
purine nucleobase metabolic process |
response to hypoxia |
purine nucleotide catabolic process |
negative regulation of apoptotic process |
response to vitamin E |
cholesterol metabolic process |
negative regulation of NF-kappaB transcription factor activity |
protein homotetramerization |
aerobic respiration |
cellular response to growth factor stimulus |
Cellular Component |
peroxisomal matrix |
peroxisomal membrane |
mitochondrial intermembrane space |
cytosol |
endoplasmic reticulum |
plasma membrane |
Golgi apparatus |
lysosome |
Function |
peroxidase activity |
ion binding |
cation binding |
metal ion binding |
binding |
transition metal ion binding |
iron ion binding |
antioxidant activity |
heme binding |
catalase activity |
Molecular Function |
protein homodimerization activity |
aminoacylase activity |
catalase activity |
metal ion binding |
NADP binding |
heme binding |
Process |
response to stimulus |
response to stress |
response to oxidative stress |
metabolic process |
oxidation reduction |
|
Cellular Location
|
- Peroxisome
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Glyoxylate and dicarboxylate metabolism | Not Available | | Peroxisome | Not Available | | Amyotrophic lateral sclerosis (ALS) | Not Available | | Degradation of Superoxides | | Not Available | Ethanol Degradation | | Not Available |
|
Gene Properties |
Chromosome Location
| 11 |
Locus
| 11p13 |
SNPs
| CAT |
Gene Sequence
|
>1584 bp
ATGGCTGACAGCCGGGATCCCGCCAGCGACCAGATGCAGCACTGGAAGGAGCAGCGGGCC
GCGCAGAAAGCTGATGTCCTGACCACTGGAGCTGGTAACCCAGTAGGAGACAAACTTAAT
GTTATTACAGTAGGGCCCCGTGGGCCCCTTCTTGTTCAGGATGTGGTTTTCACTGATGAA
ATGGCTCATTTTGACCGAGAGAGAATTCCTGAGAGAGTTGTGCATGCTAAAGGAGCAGGG
GCCTTTGGCTACTTTGAGGTCACACATGACATTACCAAATACTCCAAGGCAAAGGTATTT
GAGCATATTGGAAAGAAGACTCCCATCGCAGTTCGGTTCTCCACTGTTGCTGGAGAATCG
GGTTCAGCTGACACAGTTCGGGACCCTCGTGGGTTTGCAGTGAAATTTTACACAGAAGAT
GGTAACTGGGATCTCGTTGGAAATAACACCCCCATTTTCTTCATCAGGGATCCCATATTG
TTTCCATCTTTTATCCACAGCCAAAAGAGAAATCCTCAGACACATCTGAAGGATCCGGAC
ATGGTCTGGGACTTCTGGAGCCTACGTCCTGAGTCTCTGCATCAGGTTTCTTTCTTGTTC
AGTGATCGGGGGATTCCAGATGGACATCGCCACATGAATGGATATGGATCACATACTTTC
AAGCTGGTTAATGCAAATGGGGAGGCAGTTTATTGCAAATTCCATTATAAGACTGACCAG
GGCATCAAAAACCTTTCTGTTGAAGATGCGGCGAGACTTTCCCAGGAAGATCCTGACTAT
GGCATCCGGGATCTTTTTAACGCCATTGCCACAGGAAAGTACCCCTCCTGGACTTTTTAC
ATCCAGGTCATGACATTTAATCAGGCAGAAACTTTTCCATTTAATCCATTCGATCTCACC
AAGGTTTGGCCTCACAAGGACTACCCTCTCATCCCAGTTGGTAAACTGGTCTTAAACCGG
AATCCAGTTAATTACTTTGCTGAGGTTGAACAGATAGCCTTCGACCCAAGCAACATGCCA
CCTGGCATTGAGGCCAGTCCTGACAAAATGCTTCAGGGCCGCCTTTTTGCCTATCCTGAC
ACTCACCGCCATCGCCTGGGACCCAATTATCTTCATATACCTGTGAACTGTCCCTACCGT
GCTCGAGTGGCCAACTACCAGCGTGATGGCCCGATGTGCATGCAGGACAATCAGGGTGGT
GCTCCAAATTACTACCCCAACAGCTTTGGTGCTCCGGAACAACAGCCTTCTGCCCTGGAG
CACAGCATCCAATATTCTGGAGAAGTGCGGAGATTCAACACTGCCAATGATGATAACGTT
ACTCAGGTGCGGGCATTCTATGTGAACGTGCTGAATGAGGAACAGAGGAAACGTCTGTGT
GAGAACATTGCCGGCCACCTGAAGGATGCACAAATTTTCATCCAGAAGAAAGCGGTCAAG
AACTTCACTGAGGTCCACCCTGACTACGGGAGCCACATCCAGGCTCTTCTGGACAAGTAC
AATGCTGAGAAGCCTAAGAATGCGATTCACACCTTTGTGCAGTCCGGATCTCACTTGGCG
GCAAGGGAGAAGGCAAATCTGTGA
|
Protein Properties |
Number of Residues
| 527 |
Molecular Weight
| 59755.82 |
Theoretical pI
| 7.384 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Catalase
MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE
MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES
GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD
MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ
GIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLT
KVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPD
THRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALE
HSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVK
NFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL
|
External Links |
GenBank ID Protein
| 29721 |
UniProtKB/Swiss-Prot ID
| P04040 |
UniProtKB/Swiss-Prot Entry Name
| CATA_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| X04076 |
GeneCard ID
| CAT |
GenAtlas ID
| CAT |
HGNC ID
| HGNC:1516 |
References |
General References
| Not Available |