Identification |
HMDB Protein ID
| CDBP01432 |
Secondary Accession Numbers
| Not Available |
Name
| Cytochrome P450 2E1 |
Description
| Not Available |
Synonyms
|
- 4-nitrophenol 2-hydroxylase
- CYPIIE1
- Cytochrome P450-J
|
Gene Name
| CYP2E1 |
Protein Type
| Metal Binding |
Biological Properties |
General Function
| Involved in monooxygenase activity |
Specific Function
| Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
|
GO Classification
|
Biological Process |
response to organic nitrogen |
response to drug |
response to ethanol |
heterocycle metabolic process |
monoterpenoid metabolic process |
steroid metabolic process |
xenobiotic metabolic process |
response to ozone |
triglyceride metabolic process |
small molecule metabolic process |
drug metabolic process |
Cellular Component |
endoplasmic reticulum membrane |
mitochondrion |
intrinsic to endoplasmic reticulum membrane |
Golgi membrane |
Function |
binding |
catalytic activity |
transition metal ion binding |
electron carrier activity |
iron ion binding |
monooxygenase activity |
heme binding |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
oxidoreductase activity |
ion binding |
cation binding |
metal ion binding |
Molecular Function |
electron carrier activity |
oxygen binding |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
iron ion binding |
heme binding |
Process |
oxidation reduction |
metabolic process |
|
Cellular Location
|
- Peripheral membrane protein
- Peripheral membrane protein
- Endoplasmic reticulum membrane
- Microsome membrane
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Linoleic acid metabolism | Not Available | | Metabolism of xenobiotics by cytochrome P450 | Not Available | | Drug metabolism - cytochrome P450 | Not Available | | Chemical carcinogenesis | Not Available | | Ethanol Degradation | | Not Available |
|
Gene Properties |
Chromosome Location
| 10 |
Locus
| 10q24.3-qter |
SNPs
| CYP2E1 |
Gene Sequence
|
>1482 bp
ATGTCTGCCCTCGGAGTGACCGTGGCCCTGCTGGTGTGGGCGGCCTTCCTCCTGCTGGTG
TCCATGTGGAGGCAGGTGCACAGCAGCTGGAATCTGCCCCCAGGTCCTTTCCCGCTTCCC
ATCATCGGGAACCTCTTCCAGTTGGAATTGAAGAATATTCCCAAGTCCTTCACCCGGTTG
GCCCAGCGCTTCGGGCCGGTGTTCACGCTGTACGTGGGCTCGCAGCGCATGGTGGTGATG
CACGGCTACAAGGCGGTGAAGGAAGCGCTGCTGGACTACAAGGACGAGTTCTCGGGCAGA
GGCGACCTCCCCGCGTTCCATGCGCACAGGGACAGGGGAATCATTTTTAATAATGGACCT
ACCTGGAAGGACATCCGGCGGTTTTCCCTGACCACCCTCCGGAACTATGGGATGGGGAAA
CAGGGCAATGAGAGCCGGATCCAGAGGGAGGCCCACTTCCTGCTGGAAGCACTCAGGAAG
ACCCAAGGCCAGCCTTTCGACCCCACCTTCCTCATCGGCTGCGCGCCCTGCAACGTCATA
GCCGACATCCTCTTCCGCAAGCATTTTGACTACAATGATGAGAAGTTTCTAAGGCTGATG
TATTTGTTTAATGAGAACTTCCACCTACTCAGCACTCCCTGGCTCCAGCTTTACAATAAT
TTTCCCAGCTTTCTACACTACTTGCCTGGAAGCCACAGAAAAGTCATAAAAAATGTGGCT
GAAGTAAAAGAGTATGTGTCTGAAAGGGTGAAGGAGCACCATCAATCTCTGGACCCCAAC
TGTCCCCGGGACCTCACCGACTGCCTGCTCGTGGAAATGGAGAAGGAAAAGCACAGTGCA
GAGCGCTTGTACACAATGGACGGTATCACCGTGACTGTGGCCGACCTGTTCTTTGCGGGG
ACAGAGACCACCAGCACAACTCTGAGATATGGGCTCCTGATTCTCATGAAATACCCTGAG
ATCGAAGAGAAGCTCCATGAAGAAATTGACAGGGTGATTGGGCCAAGCCGAATCCCTGCC
ATCAAGGATAGGCAAGAGATGCCCTACATGGATGCTGTGGTGCATGAGATTCAGCGGTTC
ATCACCCTCGTGCCCTCCAACCTGCCCCATGAAGCAACCCGAGACACCATTTTCAGAGGA
TACCTCATCCCCAAGGGCACAGTCGTAGTGCCAACTCTGGACTCTGTTTTGTATGACAAC
CAAGAATTTCCTGATCCAGAAAAGTTTAAGCCAGAACACTTCCTGAATGAAAATGGAAAG
TTCAAGTACAGTGACTATTTCAAGCCATTTTCCACAGGAAAACGAGTGTGTGCTGGAGAA
GGCCTGGCTCGCATGGAGTTGTTTCTTTTGTTGTGTGCCATTTTGCAGCATTTTAATTTG
AAGCCTCTCGTTGACCCAAAGGATATCGACCTCAGCCCTATACATATTGGGTTTGGCTGT
ATCCCACCACGTTACAAACTCTGTGTCATTCCCCGCTCATGA
|
Protein Properties |
Number of Residues
| 493 |
Molecular Weight
| 56848.42 |
Theoretical pI
| 8.104 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Cytochrome P450 2E1
MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL
AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP
TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI
ADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVA
EVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG
TETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRF
ITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGK
FKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGC
IPPRYKLCVIPRS
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| P05181 |
UniProtKB/Swiss-Prot Entry Name
| CP2E1_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| J02625 |
GeneCard ID
| CYP2E1 |
GenAtlas ID
| CYP2E1 |
HGNC ID
| HGNC:2631 |
References |
General References
| Not Available |