Identification |
HMDB Protein ID
| CDBP02468 |
Secondary Accession Numbers
| Not Available |
Name
| 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase |
Description
| Not Available |
Synonyms
|
- 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase
- CYPVIIIB1
- Cytochrome P450 8B1
- Sterol 12-alpha-hydroxylase
|
Gene Name
| CYP8B1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in monooxygenase activity |
Specific Function
| Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids.
|
GO Classification
|
Biological Process |
bile acid biosynthetic process |
xenobiotic metabolic process |
Cellular Component |
endoplasmic reticulum membrane |
integral to membrane |
Function |
cation binding |
metal ion binding |
binding |
catalytic activity |
transition metal ion binding |
electron carrier activity |
iron ion binding |
monooxygenase activity |
heme binding |
oxidoreductase activity |
ion binding |
Molecular Function |
electron carrier activity |
oxygen binding |
iron ion binding |
heme binding |
7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity |
sterol 12-alpha-hydroxylase activity |
|
Cellular Location
|
- Endoplasmic reticulum membrane
- Single-pass membrane protein
- Single-pass membrane protein
- Microsome membrane
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Primary bile acid biosynthesis | Not Available | | PPAR signaling pathway | Not Available | | Bile Acid Biosynthesis | | | Congenital Bile Acid Synthesis Defect Type II | | Not Available | Congenital Bile Acid Synthesis Defect Type III | | Not Available |
|
Gene Properties |
Chromosome Location
| 3 |
Locus
| 3p22.1 |
SNPs
| CYP8B1 |
Gene Sequence
|
>1506 bp
ATGGTTCTCTGGGGTCCAGTGCTGGGAGCTCTGCTGGTGGTCATTGCTGGATACCTGTGC
CTGCCAGGGATGCTCCGACAACGCAGGCCATGGGAGCCCCCTCTGGACAAGGGTACCGTG
CCCTGGCTTGGCCATGCCATGGCTTTCCGGAAGAATATGTTTGAATTTCTGAAGCGCATG
AGGACCAAGCATGGGGATGTGTTCACAGTGCAGCTAGGGGGCCAGTACTTCACCTTCGTC
ATGGACCCCCTCTCCTTTGGCCCCATCCTCAAGGACACACAGAGAAAACTAGACTTTGGG
CAATATGCAAAAAAACTGGTGCTGAAGGTATTTGGATACCGTTCAGTGCAAGGGGACCAT
GAGATGATACACTCAGCCAGCACCAAGCATCTGAGGGGGGATGGCTTGAAGGATCTTAAT
GAGACCATGCTGGACAGCCTGTCCTTTGTAATGCTGACGTCCAAAGGCTGGAGTCTGGAT
GCCAGTTGCTGGCATGAGGACAGCCTCTTTCGCTTCTGCTATTACATCTTGTTCACAGCT
GGCTACCTGAGCTTGTTCGGCTACACGAAGGACAAGGAGCAGGACCTGCTACAGGCAGGA
GAGTTATTCATGGAGTTCCGCAAGTTTGACCTTCTTTTCCCAAGGTTTGTCTACTCCCTG
CTGTGGCCCCGGGAGTGGCTAGAAGTGGGCCGACTCCAGCGTCTCTTTCACAAGATGCTC
TCCGTGAGCCACAGCCAGGAGAAGGAGGGCATCAGCAACTGGCTGGGCAACATGCTTCAG
TTTCTGAGGGAGCAGGGGGTACCCTCAGCTATGCAGGACAAGTTCAACTTCATGATGCTC
TGGGCCTCCCAGGGGAACACGGGGCCTACCTCTTTCTGGGCCCTCTTGTACCTCCTGAAG
CACCCAGAAGCTATTCGGGCTGTGAGGGAGGAAGCTACCCAGGTCCTGGGTGAGGCCAGG
CTGGAGACCAAGCAGTCCTTTGCCTTCAAACTCGGTGCCCTGCAACACACCCCAGTTCTA
GACAGCGTGGTGGAGGAGACGCTGCGGCTGAGGGCTGCACCCACCCTCCTCAGGTTGGTT
CATGAAGACTATACCCTGAAGATGTCCAGTGGGCAGGAGTATCTGTTCCGCCATGGAGAC
ATCCTGGCCCTCTTTCCCTACCTCTCAGTGCACATGGACCCTGACATCCACCCTGAGCCC
ACCGTCTTCAAGTACGATCGCTTCCTCAACCCTAATGGCAGCCGGAAAGTGGACTTCTTC
AAGACAGGCAAGAAGATCCACCACTACACCATGCCCTGGGGTTCGGGCGTTTCCATCTGC
CCTGGGAGGTTCTTTGCACTCAGTGAGGTGAAGCTCTTTATCCTGCTTATGGTCACACAC
TTTGACTTAGAGTTGGTGGACCCTGACACACCACTACCCCATGTTGACCCGCAGCGCTGG
GGTTTTGGCACCATGCAGCCCAGCCACGATGTGCGCTTCCGCTACCGCCTGCATCCTACA
GAGTGA
|
Protein Properties |
Number of Residues
| 501 |
Molecular Weight
| 58068.01 |
Theoretical pI
| 8.663 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
MVLWGPVLGALLVVIAGYLCLPGMLRQRRPWEPPLDKGTVPWLGHAMAFRKNMFEFLKRM
RTKHGDVFTVQLGGQYFTFVMDPLSFGSILKDTQRKLDFGQYAKKLVLKVFGYRSVQGDH
EMIHSASTKHLRGDGLKDLNETMLDSLSFVMLTSKGWSLDASCWHEDSLFRFCYYILFTA
GYLSLFGYTKDKEQDLLQAGELFMEFRKFDLLFPRFVYSLLWPREWLEVGRLQRLFHKML
SVSHSQEKEGISNWLGNMLQFLREQGVPSAMQDKFNFMMLWASQGNTGPTSFWALLYLLK
HPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTPVLDSVVEETLRLRAAPTLLRLV
HEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDRFLNPNGSRKVDFF
KTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTPLPHVDPQRW
GFGTMQPSHDVRFRYRLHPTE
|
External Links |
GenBank ID Protein
| 4406150 |
UniProtKB/Swiss-Prot ID
| Q9UNU6 |
UniProtKB/Swiss-Prot Entry Name
| CP8B1_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AF090320 |
GeneCard ID
| CYP8B1 |
GenAtlas ID
| CYP8B1 |
HGNC ID
| HGNC:2653 |
References |
General References
| Not Available |