Identification |
HMDB Protein ID
| CDBP00245 |
Secondary Accession Numbers
| Not Available |
Name
| Coproporphyrinogen-III oxidase, mitochondrial |
Description
| Not Available |
Synonyms
|
- COX
- Coprogen oxidase
- Coproporphyrinogenase
|
Gene Name
| CPOX |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in coproporphyrinogen oxidase activity |
Specific Function
| Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III.
|
GO Classification
|
Biological Process |
response to iron ion |
response to insecticide |
response to lead ion |
response to methylmercury |
small molecule metabolic process |
response to arsenic-containing substance |
heme biosynthetic process |
protoporphyrinogen IX biosynthetic process |
Cellular Component |
mitochondrial inner membrane |
mitochondrial intermembrane space |
Function |
oxidoreductase activity, acting on the ch-ch group of donors |
catalytic activity |
oxidoreductase activity, acting on the ch-ch group of donors, oxygen as acceptor |
oxidoreductase activity |
coproporphyrinogen oxidase activity |
Molecular Function |
protein homodimerization activity |
coproporphyrinogen oxidase activity |
Process |
porphyrin metabolic process |
oxidation reduction |
porphyrin biosynthetic process |
metabolic process |
nitrogen compound metabolic process |
tetrapyrrole metabolic process |
|
Cellular Location
|
- Mitochondrion intermembrane space
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | protoporphyrin-IX biosynthesis | Not Available | Not Available | Porphyrin and chlorophyll metabolism | Not Available | | Porphyrin Metabolism | | | Acute Intermittent Porphyria | | Not Available | Porphyria Variegata (PV) | | Not Available |
|
Gene Properties |
Chromosome Location
| 3 |
Locus
| 3q12 |
SNPs
| CPOX |
Gene Sequence
|
>1365 bp
ATGGCCTTGCAGCTGGGCAGGCTGAGCTCGGGCCCCTGCTGGCTCGTGGCGCGGGGCGGC
TGCGGAGGGCCCCGCGCCTGGTCCCAGTGCGGCGGCGGAGGGCTCCGAGCCTGGTCCCAG
CGCAGCGCAGCCGGACGCGTCTGCCGGCCCCCTGGCCCGGCTGGCACGGAGCAGAGCCGC
GGGCTGGGGCACGGCTCGACGTCGAGAGGCGGCCCCTGGGTGGGGACAGGGCTGGCCGCG
GCGCTGGCGGGGTTGGTGGGGCTGGCCACCGCCGCCTTCGGGCATGTGCAGCGGGCGGAG
ATGTTGCCTAAGACCTCGGGGACGCGGGCCACTTCGCTGGGGAGGCCGGAGGAGGAGGAG
GATGAGCTGGCCCACCGCTGCAGCAGCTTCATGGCCCCGCCTGTGACCGACCTGGGCGAG
CTGCGAAGGAGGCCGGGCGACATGAAGACCAAGATGGAGCTGCTGATTCTGGAGACCCAG
GCCCAGGTGTGCCAGGCTCTGGCACAGGTAGACGGGGGCGCCAACTTTTCTGTGGACCGG
TGGGAGAGGAAGGAAGGAGGTGGCGGCATCAGCTGTGTACTTCAAGATGGGTGTGTTTTC
GAAAAGGCTGGGGTGAGCATTTCTGTTGTTCATGGAAATCTTTCAGAGGAAGCTGCAAAA
CAAATGAGAAGCAGAGGAAAAGTTCTGAAGACTAAAGATGGTAAATTGCCATTTTGTGCT
ATGGGCGTGAGCTCTGTTATCCACCCCAAGAATCCTCATGCTCCTACTATCCATTTCAAC
TACAGATACTTTGAAGTAGAAGAAGCTGATGGCAACAAGCAGTGGTGGTTTGGTGGTGGA
TGTGACCTCACTCCAACATACTTGAATCAAGAAGACGCTGTCCATTTTCACAGAACTCTG
AAGGAGGCTTGTGACCAGCATGGTCCAGATCTCTACCCCAAATTTAAAAAATGGTGTGAT
GATTACTTCTTTATAGCCCATCGTGGAGAACGGCGGGGCATTGGTGGTATCTTTTTTGAT
GATCTTGACTCTCCGTCCAAGGAGGAGGTGTTTCGCTTTGTACAGAGCTGTGCCAGGGCT
GTAGTTCCTTCTTACATTCCCCTTGTGAAAAAGCACTGTGATGACTCATTCACCCCCCAG
GAGAAGCTGTGGCAGCAGCTCAGAAGAGGACGGTATGTAGAATTTAATCTGCTGTATGAT
CGGGGCACAAAGTTTGGCCTCTTCACTCCAGGATCCAGAATTGAAAGTATCTTGATGTCT
TTACCTCTAACTGCCCGATGGGAGTACATGCATTCACCCTCAGAGAATTCCAAAGAAGCT
GAAATTCTGGAAGTTCTACGCCATCCAAGGGACTGGGTGCGTTGA
|
Protein Properties |
Number of Residues
| 454 |
Molecular Weight
| 50151.605 |
Theoretical pI
| 8.253 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Coproporphyrinogen-III oxidase, mitochondrial
MALQLGRLSSGPCWLVARGGCGGPRAWSQCGGGGLRAWSQRSAAGRVCRPPGPAGTEQSR
GLGHGSTSRGGPWVGTGLAAALAGLVGLATAAFGHVQRAEMLPKTSGTRATSLGRPEEEE
DELAHRCSSFMAPPVTDLGELRRRPGDMKTKMELLILETQAQVCQALAQVDGGANFSVDR
WERKEGGGGISCVLQDGCVFEKAGVSISVVHGNLSEEAAKQMRSRGKVLKTKDGKLPFCA
MGVSSVIHPKNPHAPTIHFNYRYFEVEEADGNKQWWFGGGCDLTPTYLNQEDAVHFHRTL
KEACDQHGPDLYPKFKKWCDDYFFIAHRGERRGIGGIFFDDLDSPSKEEVFRFVQSCARA
VVPSYIPLVKKHCDDSFTPQEKLWQQLRRGRYVEFNLLYDRGTKFGLFTPGSRIESILMS
LPLTARWEYMHSPSENSKEAEILEVLRHPRDWVR
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| P36551 |
UniProtKB/Swiss-Prot Entry Name
| HEM6_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| AK290140 |
GeneCard ID
| CPOX |
GenAtlas ID
| CPOX |
HGNC ID
| HGNC:2321 |
References |
General References
| Not Available |