Cannabis Compound Database: Showing Protein Peroxiredoxin-6 (CDBP00275)

Identification Biological properties Gene properties Protein properties External links References XML Show 9 compounds

Identification

HMDB Protein ID

CDBP00275

Secondary Accession Numbers

Not Available

Name

Peroxiredoxin-6

Description

Not Available

Synonyms

1-Cys PRX
1-Cys peroxiredoxin
24 kDa protein
Acidic calcium-independent phospholipase A2
Antioxidant protein 2
Liver 2D page spot 40
NSGPx
Non-selenium glutathione peroxidase
Red blood cells page spot 12
aiPLA2

Gene Name

PRDX6

Protein Type

Enzyme

Biological Properties

General Function

Involved in antioxidant activity

Specific Function

Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.

GO Classification

Biological Process
phospholipid catabolic process
hydrogen peroxide catabolic process
response to oxidative stress
Cellular Component
cytosol
lysosome
cytoplasmic membrane-bounded vesicle
Function
peroxiredoxin activity
catalytic activity
antioxidant activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity
Molecular Function
glutathione peroxidase activity
phospholipase A2 activity
peroxiredoxin activity
antioxidant activity
Process
cell redox homeostasis
cellular process
cellular homeostasis

Cellular Location

Cytoplasm
Lysosome
Cytoplasmic vesicle

Pathways

Name	SMPDB/Pathwhiz	KEGG
Phenylalanine metabolism	Not Available

Gene Properties

Chromosome Location

Locus

1q25.1

SNPs

PRDX6

Gene Sequence

>675 bp
ATGCCCGGAGGTCTGCTTCTCGGGGACGTGGCTCCCAACTTTGAGGCCAATACCACCGTC
GGCCGCATCCGTTTCCACGACTTTCTGGGAGACTCATGGGGCATTCTCTTCTCCCACCCT
CGGGACTTTACCCCAGTGTGCACCACAGAGCTTGGCAGAGCTGCAAAGCTGGCACCAGAA
TTTGCCAAGAGGAATGTTAAGTTGATTGCCCTTTCAATAGACAGTGTTGAGGACCATCTT
GCCTGGAGCAAGGATATCAATGCTTACAATTGTGAAGAGCCCACAGAAAAGTTACCTTTT
CCCATCATCGATGATAGGAATCGGGAGCTTGCCATCCTGTTGGGCATGCTGGATCCAGCA
GAGAAGGATGAAAAGGGCATGCCTGTGACAGCTCGTGTGGTGTTTGTTTTTGGTCCTGAT
AAGAAGCTGAAGCTGTCTATCCTCTACCCAGCTACCACTGGCAGGAACTTTGATGAGATT
CTCAGGGTAGTCATCTCTCTCCAGCTGACAGCAGAAAAAAGGGTTGCCACCCCAGTTGAT
TGGAAGGATGGGGATAGTGTGATGGTCCTTCCAACCATCCCTGAAGAAGAAGCCAAAAAA
CTTTTCCCGAAAGGAGTCTTCACCAAAGAGCTCCCATCTGGCAAGAAATACCTCCGCTAC
ACACCCCAGCCTTAA

Protein Properties

Number of Residues

224

Molecular Weight

25034.715

Theoretical pI

6.378

Pfam Domain Function

1-cysPrx_C (PF10417 )
AhpC-TSA (PF00578 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Peroxiredoxin-6
MPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPE
FAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPA
EKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVD
WKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

P30041

UniProtKB/Swiss-Prot Entry Name

PRDX6_HUMAN

PDB IDs