Cannabis Compound Database: Showing Protein Dimethylaniline monooxygenase [N-oxide-forming] 1 (CDBP00180)

Identification Biological properties Gene properties Protein properties External links References XML Show 6 compounds

Identification

HMDB Protein ID

CDBP00180

Secondary Accession Numbers

Not Available

Name

Dimethylaniline monooxygenase [N-oxide-forming] 1

Description

Not Available

Synonyms

Dimethylaniline oxidase 1
FMO 1
Fetal hepatic flavin-containing monooxygenase 1

Gene Name

FMO1

Protein Type

Enzyme

Biological Properties

General Function

Involved in flavin-containing monooxygenase activity

Specific Function

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.

GO Classification

Biological Process
toxin metabolic process
response to lipopolysaccharide
xenobiotic metabolic process
organic acid metabolic process
NADPH oxidation
response to osmotic stress
Cellular Component
intrinsic to endoplasmic reticulum membrane
endoplasmic reticulum lumen
integral to membrane
Component
intrinsic to organelle membrane
intrinsic to endoplasmic reticulum membrane
cell part
membrane part
intrinsic to membrane
Function
binding
nucleotide binding
catalytic activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
nadp or nadph binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nadh or nadph as one donor, and incorporation of one atom of oxygen
flavin-containing monooxygenase activity
oxidoreductase activity
fad or fadh2 binding
Molecular Function
N,N-dimethylaniline monooxygenase activity
NADP binding
flavin adenine dinucleotide binding
Process
metabolic process
oxidation reduction

Cellular Location

Endoplasmic reticulum membrane
Microsome membrane

Pathways

Name	SMPDB/Pathwhiz	KEGG
Drug metabolism - cytochrome P450	Not Available
Tamoxifen Action Pathway		Not Available
Tamoxifen Metabolism Pathway		Not Available

Gene Properties

Chromosome Location

Locus

1q24.3

SNPs

FMO1

Gene Sequence

>1599 bp
ATGGCCAAGCGAGTTGCCATTGTGGGAGCTGGGGTCAGCGGCCTGGCCTCCATCAAGTGC
TGTCTGGAAGAAGGACTGGAGCCCACCTGCTTTGAGAGGAGCGATGACCTTGGGGGGCTG
TGGAGATTCACCGAACATGTTGAAGAAGGCAGAGCCAGTCTCTACAAGTCTGTGGTTTCC
AACAGCTGCAAGGAGATGTCTTGTTACTCAGACTTTCCATTCCCAGAAGATTATCCAAAC
TATGTGCCAAATTCTCAATTCCTGGAATATCTCAAAATGTATGCAAACCACTTTGACCTT
CTGAAACACATTCAATTCAAGACCAAAGTCTGCAGTGTAACAAAATGCTCAGATTCTGCT
GTCTCTGGCCAATGGGAGGTGGTCACTATGCATGAAGAGAAGCAAGAGTCAGCCATCTTT
GATGCTGTCATGGTCTGCACTGGCTTTCTTACTAATCCTTATTTGCCACTGGATTCCTTT
CCAGGTATTAATGCCTTTAAAGGCCAGTACTTTCATAGCCGGCAATATAAGCATCCAGAT
ATATTTAAGGACAAGAGAGTCCTTGTGATTGGAATGGGAAATTCTGGCACAGACATTGCT
GTGGAGGCCAGCCACCTGGCGGAAAAGGTGTTCCTCAGCACCACCGGAGGGGGATGGGTG
ATCAGCCGAATCTTTGACTCGGGCTACCCATGGGACATGGTGTTCATGACACGCTTTCAG
AACATGTTGAGAAATTCCCTCCCAACCCCAATTGTGACTTGGTTGATGGAGCGAAAGATA
AACAACTGGCTCAATCATGCAAATTACGGCTTAATACCAGAAGACAGGACTCAGCTGAAA
GAGTTTGTGCTAAATGATGAGCTCCCAGGACGCATCATCACTGGGAAAGTGTTCATCAGG
CCAAGCATAAAAGAGGTAAAGGAAAACTCTGTCATATTTAACAATACTTCAAAGGAAGAG
CCTATTGACATCATTGTCTTTGCCACTGGATACACATTTGCTTTCCCCTTCCTTGATGAG
TCTGTAGTGAAAGTTGAAGATGGCCAGGCCTCACTGTACAAGTATATCTTCCCTGCACAT
CTGCAAAAGCCAACCCTGGCCATTATTGGCCTCATCAAACCCTTGGGCTCCATGATACCT
ACAGGAGAAACACAAGCTCGGTGGGCTGTTCGAGTCCTGAAAGGTGTAAATAAGTTACCA
CCACCAAGTGTCATGATAGAGGAAATTAATGCAAGGAAAGAAAACAAGCCCAGTTGGTTT
GGCTTGTGCTACTGCAAGGCTTTACAATCAGATTATATCACATACATAGATGAACTCCTG
ACCTATATCAATGCAAAACCCAACCTGTTCTCTATGCTCCTAACGGATCCACATCTGGCT
CTGACCGTCTTCTTTGGCCCATGCTCACCATACCAGTTCCGCTTGACTGGCCCAGGAAAA
TGGGAAGGAGCCAGAAATGCCATCATGACCCAGTGGGACCGAACATTCAAGGTCATCAAA
GCTCGAGTTGTACAAGAGTCTCCATCTCCCTTTGAAAGTTTTCTTAAAGTCTTTAGCTTT
CTGGCTTTGCTTGTGGCTATTTTTCTGATTTTCCTATAA

Protein Properties

Number of Residues

532

Molecular Weight

60310.285

Theoretical pI

7.201

Pfam Domain Function

FMO-like (PF00743 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Dimethylaniline monooxygenase [N-oxide-forming] 1
MAKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEHVEEGRASLYKSVVS
NSCKEMSCYSDFPFPEDYPNYVPNSQFLEYLKMYANHFDLLKHIQFKTKVCSVTKCSDSA
VSGQWEVVTMHEEKQESAIFDAVMVCTGFLTNPYLPLDSFPGINAFKGQYFHSRQYKHPD
IFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGGWVISRIFDSGYPWDMVFMTRFQ
NMLRNSLPTPIVTWLMERKINNWLNHANYGLIPEDRTQLKEFVLNDELPGRIITGKVFIR
PSIKEVKENSVIFNNTSKEEPIDIIVFATGYTFAFPFLDESVVKVEDGQASLYKYIFPAH
LQKPTLAIIGLIKPLGSMIPTGETQARWAVRVLKGVNKLPPPSVMIEEINARKENKPSWF
GLCYCKALQSDYITYIDELLTYINAKPNLFSMLLTDPHLALTVFFGPCSPYQFRLTGPGK
WEGARNAIMTQWDRTFKVIKARVVQESPSPFESFLKVFSFLALLVAIFLIFL

External Links

GenBank ID Protein

182671

UniProtKB/Swiss-Prot ID

Q01740

UniProtKB/Swiss-Prot Entry Name

FMO1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

M64082

GeneCard ID