Cannabis Compound Database: Showing Protein Indoleamine 2,3-dioxygenase 1 (CDBP00428)

Identification Biological properties Gene properties Protein properties External links References XML Show 4 compounds

Identification

HMDB Protein ID

CDBP00428

Secondary Accession Numbers

Not Available

Name

Indoleamine 2,3-dioxygenase 1

Description

Not Available

Synonyms

IDO-1
Indoleamine-pyrrole 2,3-dioxygenase

Gene Name

IDO1

Protein Type

Enzyme

Biological Properties

General Function

Involved in heme binding

Specific Function

Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.

GO Classification

Biological Process
multicellular organismal response to stress
tryptophan catabolic process
female pregnancy
positive regulation of apoptotic process
response to lipopolysaccharide
cytokine production involved in inflammatory response
kynurenic acid biosynthetic process
negative regulation of activated T cell proliferation
negative regulation of interleukin-10 production
negative regulation of T cell apoptotic process
positive regulation of chronic inflammatory response
positive regulation of interleukin-12 production
positive regulation of T cell tolerance induction
positive regulation of type 2 immune response
tryptophan catabolic process to kynurenine
behavior
Cellular Component
cytosol
smooth muscle contractile fiber
stereocilium bundle
Function
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
iron ion binding
heme binding
Molecular Function
heme binding
amino acid binding
electron carrier activity
oxygen binding
metal ion binding
indoleamine 2,3-dioxygenase activity
tryptophan 2,3-dioxygenase activity

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
L-tryptophan degradation via kynurenine pathway	Not Available	Not Available
African trypanosomiasis	Not Available
Tryptophan Metabolism

Gene Properties

Chromosome Location

Locus

8p12-p11

SNPs

IDO1

Gene Sequence

>1212 bp
ATGGCACACGCTATGGAAAACTCCTGGACAATCAGTAAAGAGTACCATATTGATGAAGAA
GTGGGCTTTGCTCTGCCAAATCCACAGGAAAATCTACCTGATTTTTATAATGACTGGATG
TTCATTGCTAAACATCTGCCTGATCTCATAGAGTCTGGCCAGCTTCGAGAAAGAGTTGAG
AAGTTAAACATGCTCAGCATTGATCATCTCACAGACCACAAGTCACAGCGCCTTGCACGT
CTAGTTCTGGGATGCATCACCATGGCATATGTGTGGGGCAAAGGTCATGGAGATGTCCGT
AAGGTCTTGCCAAGAAATATTGCTGTTCCTTACTGCCAACTCTCCAAGAAACTGGAACTG
CCTCCTATTTTGGTTTATGCAGACTGTGTCTTGGCAAACTGGAAGAAAAAGGATCCTAAT
AAGCCCCTGACTTATGAGAACATGGACGTTTTGTTCTCATTTCGTGATGGAGACTGCAGT
AAAGGATTCTTCCTGGTCTCTCTATTGGTGGAAATAGCAGCTGCTTCTGCAATCAAAGTA
ATTCCTACTGTATTCAAGGCAATGCAAATGCAAGAACGGGACACTTTGCTAAAGGCGCTG
TTGGAAATAGCTTCTTGCTTGGAGAAAGCCCTTCAAGTGTTTCACCAAATCCACGATCAT
GTGAACCCAAAAGCATTTTTCAGTGTTCTTCGCATATATTTGTCTGGCTGGAAAGGCAAC
CCCCAGCTATCAGACGGTCTGGTGTATGAAGGGTTCTGGGAAGACCCAAAGGAGTTTGCA
GGGGGCAGTGCAGGCCAAAGCAGCGTCTTTCAGTGCTTTGACGTCCTGCTGGGCATCCAG
CAGACTGCTGGTGGAGGACATGCTGCTCAGTTCCTCCAGGACATGAGAAGATATATGCCA
CCAGCTCACAGGAACTTCCTGTGCTCATTAGAGTCAAATCCCTCAGTCCGTGAGTTTGTC
CTTTCAAAAGGTGATGCTGGCCTGCGGGAAGCTTATGACGCCTGTGTGAAAGCTCTGGTC
TCCCTGAGGAGCTACCATCTGCAAATCGTGACTAAGTACATCCTGATTCCTGCAAGCCAG
CAGCCAAAGGAGAATAAGACCTCTGAAGACCCTTCAAAACTGGAAGCCAAAGGAACTGGA
GGCACTGATTTAATGAATTTCCTGAAGACTGTGAGAAGTACAACTGAGAAATCCCTTTTG
AAGGAAGGTTAA

Protein Properties

Number of Residues

403

Molecular Weight

45325.89

Theoretical pI

7.295

Pfam Domain Function

IDO (PF01231 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Indoleamine 2,3-dioxygenase 1
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

P14902

UniProtKB/Swiss-Prot Entry Name

I23O1_HUMAN

PDB IDs