Showing Protein Indoleamine 2,3-dioxygenase 1 (CDBP00428)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 4 compounds
Identification
HMDB Protein ID CDBP00428
Secondary Accession Numbers Not Available
Name Indoleamine 2,3-dioxygenase 1
Description Not Available
Synonyms
  1. IDO-1
  2. Indoleamine-pyrrole 2,3-dioxygenase
Gene Name IDO1
Protein Type Enzyme
Biological Properties
General Function Involved in heme binding
Specific Function Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.
GO Classification
Biological Process
multicellular organismal response to stress
tryptophan catabolic process
female pregnancy
positive regulation of apoptotic process
response to lipopolysaccharide
cytokine production involved in inflammatory response
kynurenic acid biosynthetic process
negative regulation of activated T cell proliferation
negative regulation of interleukin-10 production
negative regulation of T cell apoptotic process
positive regulation of chronic inflammatory response
positive regulation of interleukin-12 production
positive regulation of T cell tolerance induction
positive regulation of type 2 immune response
tryptophan catabolic process to kynurenine
behavior
Cellular Component
cytosol
smooth muscle contractile fiber
stereocilium bundle
Function
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
iron ion binding
heme binding
Molecular Function
heme binding
amino acid binding
electron carrier activity
oxygen binding
metal ion binding
indoleamine 2,3-dioxygenase activity
tryptophan 2,3-dioxygenase activity
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 8
Locus 8p12-p11
SNPs IDO1
Gene Sequence 
>1212 bp
ATGGCACACGCTATGGAAAACTCCTGGACAATCAGTAAAGAGTACCATATTGATGAAGAA
GTGGGCTTTGCTCTGCCAAATCCACAGGAAAATCTACCTGATTTTTATAATGACTGGATG
TTCATTGCTAAACATCTGCCTGATCTCATAGAGTCTGGCCAGCTTCGAGAAAGAGTTGAG
AAGTTAAACATGCTCAGCATTGATCATCTCACAGACCACAAGTCACAGCGCCTTGCACGT
CTAGTTCTGGGATGCATCACCATGGCATATGTGTGGGGCAAAGGTCATGGAGATGTCCGT
AAGGTCTTGCCAAGAAATATTGCTGTTCCTTACTGCCAACTCTCCAAGAAACTGGAACTG
CCTCCTATTTTGGTTTATGCAGACTGTGTCTTGGCAAACTGGAAGAAAAAGGATCCTAAT
AAGCCCCTGACTTATGAGAACATGGACGTTTTGTTCTCATTTCGTGATGGAGACTGCAGT
AAAGGATTCTTCCTGGTCTCTCTATTGGTGGAAATAGCAGCTGCTTCTGCAATCAAAGTA
ATTCCTACTGTATTCAAGGCAATGCAAATGCAAGAACGGGACACTTTGCTAAAGGCGCTG
TTGGAAATAGCTTCTTGCTTGGAGAAAGCCCTTCAAGTGTTTCACCAAATCCACGATCAT
GTGAACCCAAAAGCATTTTTCAGTGTTCTTCGCATATATTTGTCTGGCTGGAAAGGCAAC
CCCCAGCTATCAGACGGTCTGGTGTATGAAGGGTTCTGGGAAGACCCAAAGGAGTTTGCA
GGGGGCAGTGCAGGCCAAAGCAGCGTCTTTCAGTGCTTTGACGTCCTGCTGGGCATCCAG
CAGACTGCTGGTGGAGGACATGCTGCTCAGTTCCTCCAGGACATGAGAAGATATATGCCA
CCAGCTCACAGGAACTTCCTGTGCTCATTAGAGTCAAATCCCTCAGTCCGTGAGTTTGTC
CTTTCAAAAGGTGATGCTGGCCTGCGGGAAGCTTATGACGCCTGTGTGAAAGCTCTGGTC
TCCCTGAGGAGCTACCATCTGCAAATCGTGACTAAGTACATCCTGATTCCTGCAAGCCAG
CAGCCAAAGGAGAATAAGACCTCTGAAGACCCTTCAAAACTGGAAGCCAAAGGAACTGGA
GGCACTGATTTAATGAATTTCCTGAAGACTGTGAGAAGTACAACTGAGAAATCCCTTTTG
AAGGAAGGTTAA
Protein Properties
Number of Residues 403
Molecular Weight 45325.89
Theoretical pI 7.295
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Indoleamine 2,3-dioxygenase 1
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P14902
UniProtKB/Swiss-Prot Entry Name I23O1_HUMAN
PDB IDs
GenBank Gene ID M34455
GeneCard ID IDO1
GenAtlas ID IDO1
HGNC ID HGNC:6059
References
General References Not Available